Q2YM57 (APT_BRUA2) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenine phosphoribosyltransferase Short name=APRT EC=2.4.2.7 | ||||
| Gene names |
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| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359391 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 181 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004 |
| Catalytic activity | AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004 |
| Pathway | Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00004 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00004. |
| Sequence similarities | Belongs to the purine/pyrimidine phosphoribosyltransferase family. |
| Sequence caution | The sequence CAJ11512.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine salvage |
| Cellular component | Cytoplasm |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvageInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 181 | 181 | Adenine phosphoribosyltransferase HAMAP MF_00004 | PRO_0000321341 | |||
Sequences
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References
| [1] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AM040264 Genomic DNA. Translation: CAJ11512.1. Different initiation. |
| RefSeq | YP_414922.1. NC_007618.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1ZN8 based on UniProtKB P07741. |
| ProteinModelPortal | Q2YM57. |
| SMR | Q2YM57. Positions 8-181. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YM57. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3788616. |
| GenomeReviews | Gene locus BAB1_1556 in contig AM040264_GR. |
| KEGG | bmf:BAB1_1556. |
| PATRIC | 17846105. VBIBruMel86222_1614. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0503. |
| HOGENOM | HBG703830. |
| ProtClustDB | PRK02304. |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB1_1556-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00004. Aden_phosphoribosyltr. [Tree] |
| InterPro | IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view] |
| KO | K00759. |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01090. Apt. 1 hit. |
| PROSITE | PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | APT_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YM57 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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