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Q2YM22

- CARA_BRUA2

UniProt

Q2YM22 - CARA_BRUA2

Protein

Carbamoyl-phosphate synthase small chain

Gene

carA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei286 – 2861NucleophileUniRule annotation
    Active sitei370 – 3701UniRule annotation
    Active sitei372 – 3721UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    2. arginine biosynthetic process Source: UniProtKB-HAMAP
    3. carbamoyl phosphate biosynthetic process Source: InterPro
    4. glutamine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Pyrimidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1535-MONOMER.
    BMEL359391:GJOQ-1535-MONOMER.
    UniPathwayiUPA00068; UER00171.
    UPA00070; UER00115.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbamoyl-phosphate synthase small chainUniRule annotation (EC:6.3.5.5UniRule annotation)
    Alternative name(s):
    Carbamoyl-phosphate synthetase glutamine chainUniRule annotation
    Gene namesi
    Name:carAUniRule annotation
    Ordered Locus Names:BAB1_1502
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Carbamoyl-phosphate synthase small chainPRO_1000138853Add
    BLAST

    Proteomic databases

    PRIDEiQ2YM22.

    Interactioni

    Subunit structurei

    Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1502.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YM22.
    SMRiQ2YM22. Positions 16-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 397189Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 205205CPSaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CarA family.UniRule annotation
    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0505.
    HOGENOMiHOG000038087.
    KOiK01956.
    OMAiKTIKMKF.
    OrthoDBiEOG61ZTH6.

    Family and domain databases

    Gene3Di3.40.50.880. 1 hit.
    3.50.30.20. 1 hit.
    HAMAPiMF_01209. CPSase_S_chain.
    InterProiIPR006274. CarbamoylP_synth_ssu.
    IPR002474. CarbamoylP_synth_ssu_N.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    [Graphical view]
    PfamiPF00988. CPSase_sm_chain. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view]
    SMARTiSM01097. CPSase_sm_chain. 1 hit.
    [Graphical view]
    SUPFAMiSSF52021. SSF52021. 1 hit.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR01368. CPSaseIIsmall. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YM22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTETTPKTAP WTVQKRTAVL VLADGTVIEG KGLGATGAVE AEVVFNTALT    50
    GYEEILTDPS YAGQIVTFTF PHIGNVGANA EDIEDLTPAN RHGAVGAIFK 100
    ADITAPSNFR AAKDLDSWLK HRGIIALAGI DTRALTALIR ERGAQNAVIA 150
    HDPNGNFDLD ALKARAANWC GLENLDLAKD VTIGQSLVWK ELPWTLQDGY 200
    GEQDAPQYHV VALDFGVKRN ILRLLTGLGA KVTVLPATAT AEDVLAHNPD 250
    GVFLSNGPGD PAATGEYAVP TIGKLVETGI PLFGICLGHQ MLALALGGRT 300
    EKMHQGHHGA NHPVKDYTTG KVEIVSMNHG FAVDSDSLPE NVEETHVSLF 350
    DGTNCGLRVV GKPVFSVQHH PEASPGPQDS HYLFRRFINL IRERKGQAPL 400
    PEREQAA 407
    Length:407
    Mass (Da):43,536
    Last modified:February 7, 2006 - v1
    Checksum:iD6C01AFF0592F7E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11458.1.
    RefSeqiYP_414870.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11458; CAJ11458; BAB1_1502.
    GeneIDi3788048.
    KEGGibmf:BAB1_1502.
    PATRICi17845997. VBIBruMel86222_1560.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11458.1 .
    RefSeqi YP_414870.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YM22.
    SMRi Q2YM22. Positions 16-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1502.

    Proteomic databases

    PRIDEi Q2YM22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11458 ; CAJ11458 ; BAB1_1502 .
    GeneIDi 3788048.
    KEGGi bmf:BAB1_1502.
    PATRICi 17845997. VBIBruMel86222_1560.

    Phylogenomic databases

    eggNOGi COG0505.
    HOGENOMi HOG000038087.
    KOi K01956.
    OMAi KTIKMKF.
    OrthoDBi EOG61ZTH6.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00171 .
    UPA00070 ; UER00115 .
    BioCyci BABO359391:GKDV-1535-MONOMER.
    BMEL359391:GJOQ-1535-MONOMER.

    Miscellaneous databases

    PROi Q2YM22.

    Family and domain databases

    Gene3Di 3.40.50.880. 1 hit.
    3.50.30.20. 1 hit.
    HAMAPi MF_01209. CPSase_S_chain.
    InterProi IPR006274. CarbamoylP_synth_ssu.
    IPR002474. CarbamoylP_synth_ssu_N.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    [Graphical view ]
    Pfami PF00988. CPSase_sm_chain. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view ]
    SMARTi SM01097. CPSase_sm_chain. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52021. SSF52021. 1 hit.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR01368. CPSaseIIsmall. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiCARA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YM22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3