Q2YLZ8 (RS12_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
30S ribosomal protein S12

Gene names

Name:	rpsL
Ordered Locus Names:	BAB1_1260

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	With S4 and S5 plays an important role in translational accuracy By similarity. HAMAP-Rule MF_00403 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity. HAMAP-Rule MF_00403
Subunit structure	Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.
Sequence similarities	Belongs to the ribosomal protein S12P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 123	123	30S ribosomal protein S12 HAMAP-Rule MF_00403		PRO_0000226378
Amino acid modifications
	Modified residue	89	1	3-methylthioaspartic acid By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YLZ8 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 183E267BBD72B54B	FASTA	123	13,871
	10 20 30 40 50 60 MPTVNQLIRK PRTAPVKRNK VPALQANPQK RGVCTRVYTT TPKKPNSALR KVAKVRLTNG 70 80 90 100 110 120 FEVIGYIPGE GHNLQEHSVV MIRGGRVKDL PGVRYHIIRG VLDTQGVKNR KQRRSKYGAK RPK

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ11216.1.
RefSeq	YP_414646.1. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YLZ8.
SMR	Q2YLZ8. Positions 3-123.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_1260.
Proteomic databases
PRIDE	Q2YLZ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ11216; CAJ11216; BAB1_1260.
GeneID	3788949.
KEGG	bmf:BAB1_1260.
PATRIC	17845479. VBIBruMel86222_1309.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0048.
HOGENOM	HOG000040063.
KO	K02950.
OMA	SCPERRG.
ProtClustDB	PRK05163.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-1282-MONOMER.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
HAMAP	MF_00403_B. Ribosomal_S12_B.
InterPro	IPR012340. NA-bd_OB-fold. IPR006032. Ribosomal_S12/S23. IPR005679. Ribosomal_S12_bac. [Graphical view]
PANTHER	PTHR11652. PTHR11652. 1 hit.
Pfam	PF00164. Ribosomal_S12. 1 hit. [Graphical view]
PIRSF	PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTS	PR01034. RIBOSOMALS12.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00981. rpsL_bact. 1 hit.
PROSITE	PS00055. RIBOSOMAL_S12. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RS12_BRUA2

Accession

Primary (citable) accession number: Q2YLZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program