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Q2YLZ8

- RS12_BRUA2

UniProt

Q2YLZ8 - RS12_BRUA2

Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    With S4 and S5 plays an important role in translational accuracy.UniRule annotation
    Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.UniRule annotation

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro
    3. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding, tRNA-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1282-MONOMER.
    BMEL359391:GJOQ-1282-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    30S ribosomal protein S12UniRule annotation
    Gene namesi
    Name:rpsLUniRule annotation
    Ordered Locus Names:BAB1_1260
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. small ribosomal subunit Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12312330S ribosomal protein S12PRO_0000226378Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei89 – 8913-methylthioaspartic acidBy similarity

    Proteomic databases

    PRIDEiQ2YLZ8.

    Interactioni

    Subunit structurei

    Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YLZ8.
    SMRiQ2YLZ8. Positions 3-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S12P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0048.
    HOGENOMiHOG000040063.
    KOiK02950.
    OMAiVARSKYG.
    OrthoDBiEOG61ZTNF.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00403_B. Ribosomal_S12_B.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view]
    PANTHERiPTHR11652. PTHR11652. 1 hit.
    PfamiPF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSiPR01034. RIBOSOMALS12.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
    PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YLZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTVNQLIRK PRTAPVKRNK VPALQANPQK RGVCTRVYTT TPKKPNSALR    50
    KVAKVRLTNG FEVIGYIPGE GHNLQEHSVV MIRGGRVKDL PGVRYHIIRG 100
    VLDTQGVKNR KQRRSKYGAK RPK 123
    Length:123
    Mass (Da):13,871
    Last modified:February 7, 2006 - v1
    Checksum:i183E267BBD72B54B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11216.1.
    RefSeqiYP_414646.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11216; CAJ11216; BAB1_1260.
    GeneIDi3788949.
    KEGGibmf:BAB1_1260.
    PATRICi17845479. VBIBruMel86222_1309.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11216.1 .
    RefSeqi YP_414646.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YLZ8.
    SMRi Q2YLZ8. Positions 3-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1260.

    Proteomic databases

    PRIDEi Q2YLZ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11216 ; CAJ11216 ; BAB1_1260 .
    GeneIDi 3788949.
    KEGGi bmf:BAB1_1260.
    PATRICi 17845479. VBIBruMel86222_1309.

    Phylogenomic databases

    eggNOGi COG0048.
    HOGENOMi HOG000040063.
    KOi K02950.
    OMAi VARSKYG.
    OrthoDBi EOG61ZTNF.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-1282-MONOMER.
    BMEL359391:GJOQ-1282-MONOMER.

    Miscellaneous databases

    PROi Q2YLZ8.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00403_B. Ribosomal_S12_B.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view ]
    PANTHERi PTHR11652. PTHR11652. 1 hit.
    Pfami PF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSi PR01034. RIBOSOMALS12.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
    PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiRS12_BRUA2
    AccessioniPrimary (citable) accession number: Q2YLZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3