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Protein

Thiamine-binding periplasmic protein

Gene

thiB

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex ThiBPQ involved in thiamine import.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine-binding periplasmic protein
Gene namesi
Name:thiB
Ordered Locus Names:BAB1_1770
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 334311Thiamine-binding periplasmic proteinPRO_0000282912Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).Curated

Structurei

3D structure databases

ProteinModelPortaliQ2YLW8.
SMRiQ2YLW8. Positions 24-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4143.
HOGENOMiHOG000272499.
KOiK02064.
OMAiHYMQVEV.
OrthoDBiEOG6D8BCG.

Family and domain databases

InterProiIPR005948. Thi_ABC_peri-bd.
IPR005967. ThiB_ABC_peri-bd.
[Graphical view]
TIGRFAMsiTIGR01254. sfuA. 1 hit.
TIGR01276. thiB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YLW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLSLLTFS LFAVIGLAPA AQAKDKLTIY TYDSFVSEWG PGPKVKENFE
60 70 80 90 100
KECDCEVNFV ASADGVALLN RLKLEGSKTA ADIVLGLDTN LTTEARASGF
110 120 130 140 150
FAPSGIDQTN VKVPGNFKDD IFVPYDYGYF AVVYDSEKLP NPPKSLKELV
160 170 180 190 200
EGDPAQKIVL QDPRTATPGL GMLLWMKSVY GDEAGAAWQK LQKRVLTVTP
210 220 230 240 250
GWSEAYGLFT KGEAPMVLSY TTSPAYHMVV EKTDRYKALA YPEGNYLQIE
260 270 280 290 300
LAAQTTTGAK NPLAKKFLAF MTGPGFQDLI PETNWMFPAG KTSKPLPAAF
310 320 330
DALPKPEKTL LIPPYEVAKN RRLWVNEWLA ATSR
Length:334
Mass (Da):36,752
Last modified:February 7, 2006 - v1
Checksum:iC8257889CA07F8D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11726.1.
RefSeqiWP_002964841.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11726; CAJ11726; BAB1_1770.
GeneIDi3788281.
KEGGibmf:BAB1_1770.
PATRICi17846568. VBIBruMel86222_1833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11726.1.
RefSeqiWP_002964841.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YLW8.
SMRiQ2YLW8. Positions 24-333.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11726; CAJ11726; BAB1_1770.
GeneIDi3788281.
KEGGibmf:BAB1_1770.
PATRICi17846568. VBIBruMel86222_1833.

Phylogenomic databases

eggNOGiCOG4143.
HOGENOMiHOG000272499.
KOiK02064.
OMAiHYMQVEV.
OrthoDBiEOG6D8BCG.

Family and domain databases

InterProiIPR005948. Thi_ABC_peri-bd.
IPR005967. ThiB_ABC_peri-bd.
[Graphical view]
TIGRFAMsiTIGR01254. sfuA. 1 hit.
TIGR01276. thiB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiTHIB_BRUA2
AccessioniPrimary (citable) accession number: Q2YLW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 7, 2006
Last modified: July 22, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.