Q2YLW8 (THIB_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine-binding periplasmic protein

Gene names

Name:	thiB
Ordered Locus Names:	BAB1_1770

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex thiBPQ involved in thiamine import By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (thiQ), two transmembrane proteins (thiP) and a solute-binding protein (thiB) Probable.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the bacterial solute-binding protein 1 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Periplasm
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 334	311	Thiamine-binding periplasmic protein		PRO_0000282912

Sequences

	Sequence		Length	Mass (Da)
	Q2YLW8 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: C8257889CA07F8D3	FASTA	334	36,752
	10 20 30 40 50 60 MRLLSLLTFS LFAVIGLAPA AQAKDKLTIY TYDSFVSEWG PGPKVKENFE KECDCEVNFV 70 80 90 100 110 120 ASADGVALLN RLKLEGSKTA ADIVLGLDTN LTTEARASGF FAPSGIDQTN VKVPGNFKDD 130 140 150 160 170 180 IFVPYDYGYF AVVYDSEKLP NPPKSLKELV EGDPAQKIVL QDPRTATPGL GMLLWMKSVY 190 200 210 220 230 240 GDEAGAAWQK LQKRVLTVTP GWSEAYGLFT KGEAPMVLSY TTSPAYHMVV EKTDRYKALA 250 260 270 280 290 300 YPEGNYLQIE LAAQTTTGAK NPLAKKFLAF MTGPGFQDLI PETNWMFPAG KTSKPLPAAF 310 320 330 DALPKPEKTL LIPPYEVAKN RRLWVNEWLA ATSR

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ11726.1.
RefSeq	YP_415117.1. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YLW8.
SMR	Q2YLW8. Positions 24-333.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YLW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3788281.
GenomeReviews	Gene locus BAB1_1770 in contig AM040264_GR.
KEGG	bmf:BAB1_1770.
PATRIC	17846568. VBIBruMel86222_1833.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4143.
HOGENOM	HBG476839.
OMA	IPTTNWM.
ProtClustDB	PRK11205.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_1770-MONOMER.
Family and domain databases
InterPro	IPR006059. Solute-bd_1_bac. IPR005948. Thi_ABC_peri-bd. IPR005967. ThiB_ABC_peri-bd. [Graphical view]
KO	K02064.
Pfam	PF01547. SBP_bac_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01254. SfuA. 1 hit. TIGR01276. ThiB. 1 hit.
PROSITE	PS01037. SBP_BACTERIAL_1. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIB_BRUA2

Accession

Primary (citable) accession number: Q2YLW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program