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Q2YLW8 (THIB_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine-binding periplasmic protein
Gene names
Name:thiB
Ordered Locus Names:BAB1_1770
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex ThiBPQ involved in thiamine import By similarity.

Subunit structure

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB) Probable.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the bacterial solute-binding protein 1 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentPeriplasm
   DomainSignal
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthiamine transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

thiamine binding

Inferred from electronic annotation. Source: InterPro

thiamine-transporting ATPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 334311Thiamine-binding periplasmic protein
PRO_0000282912

Sequences

Sequence LengthMass (Da)Tools
Q2YLW8 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: C8257889CA07F8D3

FASTA33436,752
        10         20         30         40         50         60 
MRLLSLLTFS LFAVIGLAPA AQAKDKLTIY TYDSFVSEWG PGPKVKENFE KECDCEVNFV 

        70         80         90        100        110        120 
ASADGVALLN RLKLEGSKTA ADIVLGLDTN LTTEARASGF FAPSGIDQTN VKVPGNFKDD 

       130        140        150        160        170        180 
IFVPYDYGYF AVVYDSEKLP NPPKSLKELV EGDPAQKIVL QDPRTATPGL GMLLWMKSVY 

       190        200        210        220        230        240 
GDEAGAAWQK LQKRVLTVTP GWSEAYGLFT KGEAPMVLSY TTSPAYHMVV EKTDRYKALA 

       250        260        270        280        290        300 
YPEGNYLQIE LAAQTTTGAK NPLAKKFLAF MTGPGFQDLI PETNWMFPAG KTSKPLPAAF 

       310        320        330 
DALPKPEKTL LIPPYEVAKN RRLWVNEWLA ATSR 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11726.1.
RefSeqYP_415117.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YLW8.
SMRQ2YLW8. Positions 24-333.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_1770.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11726; CAJ11726; BAB1_1770.
GeneID3788281.
KEGGbmf:BAB1_1770.
PATRIC17846568. VBIBruMel86222_1833.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4143.
HOGENOMHOG000272499.
KOK02064.
OMAHYMQVEV.
OrthoDBEOG6D8BCG.
ProtClustDBPRK11205.

Family and domain databases

InterProIPR005948. Thi_ABC_peri-bd.
IPR005967. ThiB_ABC_peri-bd.
[Graphical view]
TIGRFAMsTIGR01254. sfuA. 1 hit.
TIGR01276. thiB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIB_BRUA2
AccessionPrimary (citable) accession number: Q2YLW8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names