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Q2YLW6 (THIQ_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine import ATP-binding protein ThiQ

EC=3.6.3.-
Gene names
Name:thiQ
Ordered Locus Names:BAB1_1772
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system By similarity.

Subunit structure

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB) Potential.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. [View classification]

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity, coupled to transmembrane movement of substances

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Thiamine import ATP-binding protein ThiQ
PRO_0000274434

Regions

Domain7 – 235229ABC transporter
Nucleotide binding37 – 448ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YLW6 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 07D827263C8FE98D

FASTA24126,187
        10         20         30         40         50         60 
MTASADIRLS DVRFSYGETA MHFDVTITGG EIAAIVGPSG SGKSTFLNLI AGFETPQSGI 

        70         80         90        100        110        120 
ISINGVDVTH LPLADRPVSM VFQENNLFAH LTVEQNVDLG RSPNLRLNEE DRKAVASALA 

       130        140        150        160        170        180 
RVGLQGKEKR KPEALSGGER QRVAIARVLV RERPVLLLDE AFASLGPALR HQMLDLVNKL 

       190        200        210        220        230        240 
RRETGMTVLM VTHTPEDALH LDALLIFLDN GKIAAQGPAT EMLSRAGPEA LRHYIGEMRS 


F 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11728.1.
RefSeqYP_415119.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YLW6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_1772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11728; CAJ11728; BAB1_1772.
GeneID3788282.
KEGGbmf:BAB1_1772.
PATRIC17846572. VBIBruMel86222_1835.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3840.
KOK02062.
OMARDIMELF.
OrthoDBEOG6SNDS1.
ProtClustDBCLSK863893.

Enzyme and pathway databases

BioCycBABO359391:GKDV-1816-MONOMER.
BMEL359391:GJOQ-1816-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005968. Thiamine_ABC_ThiQ.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01277. thiQ. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51288. THIQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHIQ_BRUA2
AccessionPrimary (citable) accession number: Q2YLW6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names