Q2YLW6 (THIQ_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine import ATP-binding protein ThiQ
EC=3.6.3.-

Gene names

Name:	thiQ
Ordered Locus Names:	BAB1_1772

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB) Potential.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Thiamine import ATP-binding protein ThiQ		PRO_0000274434
Regions
	Domain	7 – 235	229	ABC transporter
	Nucleotide binding	37 – 44	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YLW6 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 07D827263C8FE98D	FASTA	241	26,187
	10 20 30 40 50 60 MTASADIRLS DVRFSYGETA MHFDVTITGG EIAAIVGPSG SGKSTFLNLI AGFETPQSGI 70 80 90 100 110 120 ISINGVDVTH LPLADRPVSM VFQENNLFAH LTVEQNVDLG RSPNLRLNEE DRKAVASALA 130 140 150 160 170 180 RVGLQGKEKR KPEALSGGER QRVAIARVLV RERPVLLLDE AFASLGPALR HQMLDLVNKL 190 200 210 220 230 240 RRETGMTVLM VTHTPEDALH LDALLIFLDN GKIAAQGPAT EMLSRAGPEA LRHYIGEMRS F

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ11728.1.
RefSeq	YP_415119.1. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YLW6.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_1772.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ11728; CAJ11728; BAB1_1772.
GeneID	3788282.
KEGG	bmf:BAB1_1772.
PATRIC	17846572. VBIBruMel86222_1835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3840.
KO	K02062.
OMA	NARMDAS.
ProtClustDB	CLSK863893.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-1816-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005968. Thiamine_ABC_ThiQ. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01277. thiQ. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51288. THIQ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIQ_BRUA2

Accession

Primary (citable) accession number: Q2YLW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program