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Q2YLR3 (GPDA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]

EC=1.1.1.94
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene names
Name:gpsA
Ordered Locus Names:BAB1_1889
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP-Rule MF_00394

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP-Rule MF_00394

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00394.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Glycerol-3-phosphate dehydrogenase [NAD(P)+] HAMAP-Rule MF_00394
PRO_0000255287

Regions

Nucleotide binding9 – 146NAD By similarity
Region254 – 2552Substrate binding By similarity

Sites

Active site1901Proton acceptor By similarity
Binding site1071NAD; via amide nitrogen By similarity
Binding site1071Substrate By similarity
Binding site1391NAD; via amide nitrogen By similarity
Binding site2541NAD By similarity
Binding site2751NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YLR3 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 9853E6E4335CA53C

FASTA32633,377
        10         20         30         40         50         60 
MSTKIAVLGG GAWGTALAAM AAKGGHESWL YARDAETVVA INKDRRNPRY LGDITLADGI 

        70         80         90        100        110        120 
RASTDAAAVV TGADAVLAVI PAQAMRNGLS ELGTLIPQAS PIVLCAKGIE QNTGRLMSEV 

       130        140        150        160        170        180 
VAEILPDHRI AALSGPSFAS DVARGLPTAV TVACEDANTA DRLAALLSGP AFRCYSTTDL 

       190        200        210        220        230        240 
KGVETGGALK NVLAIAAGAA IGRGYGASAQ AALVTRGFAE LRRIGQAMSA RPETIMGLSG 

       250        260        270        280        290        300 
LGDLMLTCSS SQSRNYSYGL ALGRGEDLTS RPLAEGVATA PIAAELCRKH NISAPIIDAV 

       310        320 
GALLDGKITI DEAVTALLNR PLKTED 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11845.1.
RefSeqYP_415231.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YLR3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_1889.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11845; CAJ11845; BAB1_1889.
GeneID3788737.
KEGGbmf:BAB1_1889.
PATRIC17846852. VBIBruMel86222_1967.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0240.
HOGENOMHOG000246853.
KOK00057.
OMAHLLHCGK.
OrthoDBEOG6JDWF4.

Enzyme and pathway databases

BioCycBABO359391:GKDV-1940-MONOMER.
BMEL359391:GJOQ-1940-MONOMER.
UniPathwayUPA00940.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00394. NAD_Glyc3P_dehydrog.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_BRUA2
AccessionPrimary (citable) accession number: Q2YLR3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names