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Q2YLR3

- GPDA_BRUA2

UniProt

Q2YLR3 - GPDA_BRUA2

Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071NAD; via amide nitrogenUniRule annotation
    Binding sitei107 – 1071SubstrateUniRule annotation
    Binding sitei139 – 1391NAD; via amide nitrogenUniRule annotation
    Active sitei190 – 1901Proton acceptorUniRule annotation
    Binding sitei254 – 2541NADUniRule annotation
    Binding sitei275 – 2751NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADUniRule annotation

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
    2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
    3. glycerol-3-phosphate catabolic process Source: InterPro
    4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
    5. phospholipid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1940-MONOMER.
    BMEL359391:GJOQ-1940-MONOMER.
    UniPathwayiUPA00940.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
    Alternative name(s):
    NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
    Gene namesi
    Name:gpsAUniRule annotation
    Ordered Locus Names:BAB1_1889
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Glycerol-3-phosphate dehydrogenase [NAD(P)+]PRO_0000255287Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_1889.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YLR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 2552Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0240.
    HOGENOMiHOG000246853.
    KOiK00057.
    OMAiHLLHCGK.
    OrthoDBiEOG6JDWF4.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YLR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTKIAVLGG GAWGTALAAM AAKGGHESWL YARDAETVVA INKDRRNPRY    50
    LGDITLADGI RASTDAAAVV TGADAVLAVI PAQAMRNGLS ELGTLIPQAS 100
    PIVLCAKGIE QNTGRLMSEV VAEILPDHRI AALSGPSFAS DVARGLPTAV 150
    TVACEDANTA DRLAALLSGP AFRCYSTTDL KGVETGGALK NVLAIAAGAA 200
    IGRGYGASAQ AALVTRGFAE LRRIGQAMSA RPETIMGLSG LGDLMLTCSS 250
    SQSRNYSYGL ALGRGEDLTS RPLAEGVATA PIAAELCRKH NISAPIIDAV 300
    GALLDGKITI DEAVTALLNR PLKTED 326
    Length:326
    Mass (Da):33,377
    Last modified:February 7, 2006 - v1
    Checksum:i9853E6E4335CA53C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11845.1.
    RefSeqiYP_415231.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11845; CAJ11845; BAB1_1889.
    GeneIDi3788737.
    KEGGibmf:BAB1_1889.
    PATRICi17846852. VBIBruMel86222_1967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11845.1 .
    RefSeqi YP_415231.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YLR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11845 ; CAJ11845 ; BAB1_1889 .
    GeneIDi 3788737.
    KEGGi bmf:BAB1_1889.
    PATRICi 17846852. VBIBruMel86222_1967.

    Phylogenomic databases

    eggNOGi COG0240.
    HOGENOMi HOG000246853.
    KOi K00057.
    OMAi HLLHCGK.
    OrthoDBi EOG6JDWF4.

    Enzyme and pathway databases

    UniPathwayi UPA00940 .
    BioCyci BABO359391:GKDV-1940-MONOMER.
    BMEL359391:GJOQ-1940-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiGPDA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YLR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3