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Q2YLM5

- HEM3_BRUA2

UniProt

Q2YLM5 - HEM3_BRUA2

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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

dipyrromethaneUniRule annotationNote: Binds 1 dipyrromethane group covalently.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1938-MONOMER.
BMEL359391:GJOQ-1938-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Short name:
HMBSUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotation
Ordered Locus Names:BAB1_1887
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Porphobilinogen deaminasePRO_0000304217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_1887.

Structurei

3D structure databases

ProteinModelPortaliQ2YLM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0181.
HOGENOMiHOG000228588.
KOiK01749.
OMAiGAICIES.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YLM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTASFKNGT LKIGTRGSKL ALAQAYLTRR LLQEAHGLPE DAIEILPMST
60 70 80 90 100
AGDRIQDRPL SEVGGKGLFT EEIEQALKDG RIDIAVHSTK DMPTALPEGL
110 120 130 140 150
HLSVFLERED PRDAFIGRSA RRFMDLPQGA TVGSSSLRRQ ALIRRLRPDI
160 170 180 190 200
EVVMYRGNVD TRLRKLDAGE VDGTFLACAG LRRLGLADVI TDVLDPSVFP
210 220 230 240 250
PAPGQGAIGI ESRIGDERID VLLAPLAHRE TQIALACERA FLGALDGSCR
260 270 280 290 300
TPIAGLATVE GDRLSFRGMI LTPDGRQAHE VTAEGVVSDA AALGTDAANR
310
VRAMAGPHFF DGWQ
Length:314
Mass (Da):33,838
Last modified:February 7, 2006 - v1
Checksum:iD4F34A01D72322B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11843.1.
RefSeqiYP_415229.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11843; CAJ11843; BAB1_1887.
GeneIDi3788370.
KEGGibmf:BAB1_1887.
PATRICi17846846. VBIBruMel86222_1964.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11843.1 .
RefSeqi YP_415229.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YLM5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11843 ; CAJ11843 ; BAB1_1887 .
GeneIDi 3788370.
KEGGi bmf:BAB1_1887.
PATRICi 17846846. VBIBruMel86222_1964.

Phylogenomic databases

eggNOGi COG0181.
HOGENOMi HOG000228588.
KOi K01749.
OMAi GAICIES.
OrthoDBi EOG6HB9Z6.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00319 .
BioCyci BABO359391:GKDV-1938-MONOMER.
BMEL359391:GJOQ-1938-MONOMER.

Family and domain databases

Gene3Di 3.30.160.40. 1 hit.
HAMAPi MF_00260. Porphobil_deam.
InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view ]
PANTHERi PTHR11557. PTHR11557. 1 hit.
Pfami PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSi PR00151. PORPHBDMNASE.
SUPFAMi SSF54782. SSF54782. 1 hit.
TIGRFAMsi TIGR00212. hemC. 1 hit.
PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiHEM3_BRUA2
AccessioniPrimary (citable) accession number: Q2YLM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3