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Q2YLM5

- HEM3_BRUA2

UniProt

Q2YLM5 - HEM3_BRUA2

Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

    Catalytic activityi

    4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

    Cofactori

    Binds 1 dipyrromethane group covalently.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-pyrromethane cofactor linkage Source: InterPro
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1938-MONOMER.
    BMEL359391:GJOQ-1938-MONOMER.
    UniPathwayiUPA00251; UER00319.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
    Short name:
    PBGUniRule annotation
    Alternative name(s):
    Hydroxymethylbilane synthaseUniRule annotation
    Short name:
    HMBSUniRule annotation
    Pre-uroporphyrinogen synthaseUniRule annotation
    Gene namesi
    Name:hemCUniRule annotation
    Ordered Locus Names:BAB1_1887
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Porphobilinogen deaminasePRO_0000304217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei249 – 2491S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1887.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YLM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMBS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0181.
    HOGENOMiHOG000228588.
    KOiK01749.
    OMAiGAICIES.
    OrthoDBiEOG6HB9Z6.

    Family and domain databases

    Gene3Di3.30.160.40. 1 hit.
    HAMAPiMF_00260. Porphobil_deam.
    InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view]
    PANTHERiPTHR11557. PTHR11557. 1 hit.
    PfamiPF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSiPR00151. PORPHBDMNASE.
    SUPFAMiSSF54782. SSF54782. 1 hit.
    TIGRFAMsiTIGR00212. hemC. 1 hit.
    PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YLM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTASFKNGT LKIGTRGSKL ALAQAYLTRR LLQEAHGLPE DAIEILPMST    50
    AGDRIQDRPL SEVGGKGLFT EEIEQALKDG RIDIAVHSTK DMPTALPEGL 100
    HLSVFLERED PRDAFIGRSA RRFMDLPQGA TVGSSSLRRQ ALIRRLRPDI 150
    EVVMYRGNVD TRLRKLDAGE VDGTFLACAG LRRLGLADVI TDVLDPSVFP 200
    PAPGQGAIGI ESRIGDERID VLLAPLAHRE TQIALACERA FLGALDGSCR 250
    TPIAGLATVE GDRLSFRGMI LTPDGRQAHE VTAEGVVSDA AALGTDAANR 300
    VRAMAGPHFF DGWQ 314
    Length:314
    Mass (Da):33,838
    Last modified:February 7, 2006 - v1
    Checksum:iD4F34A01D72322B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11843.1.
    RefSeqiYP_415229.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11843; CAJ11843; BAB1_1887.
    GeneIDi3788370.
    KEGGibmf:BAB1_1887.
    PATRICi17846846. VBIBruMel86222_1964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11843.1 .
    RefSeqi YP_415229.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YLM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1887.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11843 ; CAJ11843 ; BAB1_1887 .
    GeneIDi 3788370.
    KEGGi bmf:BAB1_1887.
    PATRICi 17846846. VBIBruMel86222_1964.

    Phylogenomic databases

    eggNOGi COG0181.
    HOGENOMi HOG000228588.
    KOi K01749.
    OMAi GAICIES.
    OrthoDBi EOG6HB9Z6.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00319 .
    BioCyci BABO359391:GKDV-1938-MONOMER.
    BMEL359391:GJOQ-1938-MONOMER.

    Family and domain databases

    Gene3Di 3.30.160.40. 1 hit.
    HAMAPi MF_00260. Porphobil_deam.
    InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view ]
    PANTHERi PTHR11557. PTHR11557. 1 hit.
    Pfami PF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSi PR00151. PORPHBDMNASE.
    SUPFAMi SSF54782. SSF54782. 1 hit.
    TIGRFAMsi TIGR00212. hemC. 1 hit.
    PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiHEM3_BRUA2
    AccessioniPrimary (citable) accession number: Q2YLM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3