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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei370 – 3701Required for activityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1768ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1853-MONOMER.
BMEL359391:GJOQ-1853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:BAB1_1809
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509ATP synthase subunit alphaPRO_0000238214Add
BLAST

Proteomic databases

PRIDEiQ2YLI5.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YLI5.
SMRiQ2YLI5. Positions 24-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0056.
HOGENOMiHOG000130111.
KOiK02111.
OMAiIINQRDN.
OrthoDBiEOG67X1S1.

Family and domain databases

Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YLI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIRAAEISA ILKEQIKNFG KEAEVSEVGQ VLSVGDGIAR VYGLDNVQAG
60 70 80 90 100
EMVEFPGGIR GMALNLESDN VGVVIFGADR DIKEGDVVKR TGAIVDVPVG
110 120 130 140 150
PELLGRVVDA LGNPIDGKGP IKAKERRRVD VKAPGIIPRK SVHEPMSTGL
160 170 180 190 200
KAIDALIPVG RGQRELVIGD RQTGKTAIIL DTFLNQKPIH DNGPDKDKLY
210 220 230 240 250
CVYVAVGQKR STVAQFVKVL EERGALEYSI VVAATASDPA PMQYLAPFAG
260 270 280 290 300
CAMGEYFRDN GQHALIGYDD LSKQAVAYRQ MSLLLRRPPG REAYPGDVFY
310 320 330 340 350
LHSRLLERAA KLNDENGAGS LTALPVIETQ GNDVSAFIPT NVISITDGQI
360 370 380 390 400
FLETNLFYQG IRPAVNVGLS VSRVGSSAQI KAMKQVAGSI KGELAQYREM
410 420 430 440 450
AAFAQFGSDL DAATQRLLNR GARLTELLKQ PQFSPLKTEE QVAVIYAGVN
460 470 480 490 500
GYLDKLAVNQ VGKFEEGLLA SLRTEHKDVL EGIRNEKALT DDLKAKLKAA

IDAFAKSFV
Length:509
Mass (Da):54,970
Last modified:February 7, 2006 - v1
Checksum:i954BCF9B79649E62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11765.1.
RefSeqiWP_002964878.1. NZ_KN046823.1.
YP_415155.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11765; CAJ11765; BAB1_1809.
GeneIDi3788628.
KEGGibmf:BAB1_1809.
PATRICi17846652. VBIBruMel86222_1875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11765.1.
RefSeqiWP_002964878.1. NZ_KN046823.1.
YP_415155.1. NC_007618.1.

3D structure databases

ProteinModelPortaliQ2YLI5.
SMRiQ2YLI5. Positions 24-501.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2YLI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11765; CAJ11765; BAB1_1809.
GeneIDi3788628.
KEGGibmf:BAB1_1809.
PATRICi17846652. VBIBruMel86222_1875.

Phylogenomic databases

eggNOGiCOG0056.
HOGENOMiHOG000130111.
KOiK02111.
OMAiIINQRDN.
OrthoDBiEOG67X1S1.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1853-MONOMER.
BMEL359391:GJOQ-1853-MONOMER.

Family and domain databases

Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039088. F_ATPase_subunit_alpha. 1 hit.
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiATPA_BRUA2
AccessioniPrimary (citable) accession number: Q2YLI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 7, 2006
Last modified: June 24, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.