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Protein

Hydroxypyruvate isomerase

Gene

BAB2_0144

Organism
Brucella abortus (strain 2308)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).UniRule annotation

Catalytic activityi

Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi142 – 1421ManganeseCombined sources
Metal bindingi177 – 1771ManganeseCombined sources
Metal bindingi203 – 2031ManganeseCombined sources
Metal bindingi239 – 2391ManganeseCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseImported, Hydrolase, IsomeraseUniRule annotationImported, Nuclease

Keywords - Ligandi

ManganeseCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2387-MONOMER.
BMEL359391:GJOQ-2387-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxypyruvate isomeraseUniRule annotation (EC:5.3.1.22UniRule annotation)
Gene namesi
Ordered Locus Names:BAB2_0144Imported
OrganismiBrucella abortus (strain 2308)Imported
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome II

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NGFX-ray1.80A/B1-261[»]
ProteinModelPortaliQ2YLA2.
SMRiQ2YLA2. Positions 1-258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2YLA2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 218198AP_endonuc_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hyi family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218197.
KOiK01816.
OMAiCANLSFM.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
InterProiIPR026040. HyI-like.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006241. HyI. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YLA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFAANLST MFNEVPFLER FRLAAEAGFG GVEFLFPYDF DADVIARELK
60 70 80 90 100
QHNLTQVLFN MPPGDWAAGE RGMAAISGRE QEFRDNVDIA LHYALALDCR
110 120 130 140 150
TLHAMSGITE GLDRKACEET FIENFRYAAD KLAPHGITVL VEPLNTRNMP
160 170 180 190 200
GYFIVHQLEA VGLVKRVNRP NVAVQLDLYH AQIMDGDLTR LIEKMNGAFS
210 220 230 240 250
HVQIASVPDR HEPDEGELNY PYLFSVLESV GYRGWVGCEY NPRGKTESGL
260
AWFAPYRDQS A
Length:261
Mass (Da):29,404
Last modified:February 7, 2006 - v1
Checksum:iF5FF5BCE3EC335A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12310.1.
RefSeqiWP_002966434.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ12310; CAJ12310; BAB2_0144.
GeneIDi3827198.
KEGGibmf:BAB2_0144.
PATRICi17847775. VBIBruMel86222_2421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12310.1.
RefSeqiWP_002966434.1. NZ_KN046823.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NGFX-ray1.80A/B1-261[»]
ProteinModelPortaliQ2YLA2.
SMRiQ2YLA2. Positions 1-258.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12310; CAJ12310; BAB2_0144.
GeneIDi3827198.
KEGGibmf:BAB2_0144.
PATRICi17847775. VBIBruMel86222_2421.

Phylogenomic databases

HOGENOMiHOG000218197.
KOiK01816.
OMAiCANLSFM.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2387-MONOMER.
BMEL359391:GJOQ-2387-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ2YLA2.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
InterProiIPR026040. HyI-like.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006241. HyI. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ2YLA2_BRUA2
AccessioniPrimary (citable) accession number: Q2YLA2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.