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Q2YL69

- NIKE_BRUA2

UniProt

Q2YL69 - NIKE_BRUA2

Protein

Nickel import ATP-binding protein NikE

Gene

nikE

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.UniRule annotation

    Catalytic activityi

    ATP + H2O + Ni2+(Out) = ADP + phosphate + Ni2+(In).UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 528ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nickel cation binding Source: InterPro
    3. nickel-transporting ATPase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Nickel transport, Transport

    Keywords - Ligandi

    ATP-binding, Nickel, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2683-MONOMER.
    BMEL359391:GJOQ-2683-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nickel import ATP-binding protein NikEUniRule annotation (EC:3.6.3.24UniRule annotation)
    Gene namesi
    Name:nikEUniRule annotation
    Ordered Locus Names:BAB2_0438
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Nickel import ATP-binding protein NikEPRO_0000260204Add
    BLAST

    Interactioni

    Subunit structurei

    The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB2_0438.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YL69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 252249ABC transporterUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. [View classification]UniRule annotation
    Contains 1 ABC transporter domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1124.
    KOiK10824.
    OMAiNPRKTVC.
    OrthoDBiEOG6T7N3V.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR015858. ABC_transpr_NikE.
    IPR014137. Nickel_NikE.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR02769. nickel_nikE. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51248. NIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YL69-1 [UniParc]FASTAAdd to Basket

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    MSLISADNIV KIYQSHSLVG ASARKTMLHD ISISIGQGET VALLGRSGCG    50
    KSTLARLLVG LERPTSGEVR FRGVPLTKLD RSGMKAFRRE VQLIFQDSPG 100
    AVNARSSVRA IIGEPLRHLT SLDETRREER IQELLRLVEL PPEIADRLPA 150
    QVSGGQLQRI CIARALAVNP KLIILDEAVS NLDIHLQASA LALLTKLQQE 200
    GGIAYLFVTH DLRLVQKFAA RCLVMDEGQI VEEIKTADLD SMRHPASRLL 250
    REAVLPPLPV RAVETN 266
    Length:266
    Mass (Da):29,180
    Last modified:February 7, 2006 - v1
    Checksum:iCBC0D12AA2731DFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12604.1.
    RefSeqiYP_418633.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12604; CAJ12604; BAB2_0438.
    GeneIDi3827147.
    KEGGibmf:BAB2_0438.
    PATRICi17848412. VBIBruMel86222_2733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12604.1 .
    RefSeqi YP_418633.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YL69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12604 ; CAJ12604 ; BAB2_0438 .
    GeneIDi 3827147.
    KEGGi bmf:BAB2_0438.
    PATRICi 17848412. VBIBruMel86222_2733.

    Phylogenomic databases

    eggNOGi COG1124.
    KOi K10824.
    OMAi NPRKTVC.
    OrthoDBi EOG6T7N3V.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2683-MONOMER.
    BMEL359391:GJOQ-2683-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR015858. ABC_transpr_NikE.
    IPR014137. Nickel_NikE.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR02769. nickel_nikE. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51248. NIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiNIKE_BRUA2
    AccessioniPrimary (citable) accession number: Q2YL69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3