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Q2YL69 (NIKE_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nickel import ATP-binding protein NikE

EC=3.6.3.24
Gene names
Name:nikE
Ordered Locus Names:BAB2_0438
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system By similarity.

Catalytic activity

ATP + H2O + Ni2+(Out) = ADP + phosphate + Ni2+(In).

Subunit structure

The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA) Potential.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. [View classification]

Contains 1 ABC transporter domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Nickel import ATP-binding protein NikE
PRO_0000260204

Regions

Domain4 – 252249ABC transporter
Nucleotide binding45 – 528ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YL69 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: CBC0D12AA2731DFB

FASTA26629,180
        10         20         30         40         50         60 
MSLISADNIV KIYQSHSLVG ASARKTMLHD ISISIGQGET VALLGRSGCG KSTLARLLVG 

        70         80         90        100        110        120 
LERPTSGEVR FRGVPLTKLD RSGMKAFRRE VQLIFQDSPG AVNARSSVRA IIGEPLRHLT 

       130        140        150        160        170        180 
SLDETRREER IQELLRLVEL PPEIADRLPA QVSGGQLQRI CIARALAVNP KLIILDEAVS 

       190        200        210        220        230        240 
NLDIHLQASA LALLTKLQQE GGIAYLFVTH DLRLVQKFAA RCLVMDEGQI VEEIKTADLD 

       250        260 
SMRHPASRLL REAVLPPLPV RAVETN 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040265 Genomic DNA. Translation: CAJ12604.1.
RefSeqYP_418633.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YL69.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0438.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12604; CAJ12604; BAB2_0438.
GeneID3827147.
KEGGbmf:BAB2_0438.
PATRIC17848412. VBIBruMel86222_2733.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1124.
KOK10824.
OMANPRKTVC.
OrthoDBEOG6T7N3V.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2683-MONOMER.
BMEL359391:GJOQ-2683-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015858. ABC_transpr_NikE.
IPR014137. Nickel_NikE.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR02769. nickel_nikE. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51248. NIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNIKE_BRUA2
AccessionPrimary (citable) accession number: Q2YL69
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names