Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q2YL33

- FOLD_BRUA2

UniProt

Q2YL33 - FOLD_BRUA2

Protein

Bifunctional protein FolD

Gene

folD

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.UniRule annotation
    5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei193 – 1931NADPUniRule annotation
    Binding sitei234 – 2341NADP; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi168 – 1703NADPUniRule annotation

    GO - Molecular functioni

    1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-HAMAP
    2. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. histidine biosynthetic process Source: UniProtKB-KW
    3. methionine biosynthetic process Source: UniProtKB-KW
    4. purine nucleotide biosynthetic process Source: UniProtKB-KW
    5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2702-MONOMER.
    BMEL359391:GJOQ-2702-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein FolDUniRule annotation
    Including the following 2 domains:
    Methylenetetrahydrofolate dehydrogenaseUniRule annotation (EC:1.5.1.5UniRule annotation)
    Methenyltetrahydrofolate cyclohydrolaseUniRule annotation (EC:3.5.4.9UniRule annotation)
    Gene namesi
    Name:folDUniRule annotation
    Ordered Locus Names:BAB2_0457
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Bifunctional protein FolDPRO_0000268294Add
    BLAST

    Proteomic databases

    PRIDEiQ2YL33.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB2_0457.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YL33.
    SMRiQ2YL33. Positions 2-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0190.
    HOGENOMiHOG000218242.
    KOiK01491.
    OMAiMAGNDES.
    OrthoDBiEOG6K6VBB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01576. THF_DHG_CYH.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view]
    PRINTSiPR00085. THFDHDRGNASE.
    PROSITEiPS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YL33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQLIDGKKL AEDVVSTVKT ETEKLVAATG VVPGIAVVIV GEDPASQVYV    50
    ASKSRKAKEC GFHSVQHDLP ETASEQELLN LIEGLNNDPA IHGILVQLPL 100
    PGHIDSGRVI QTIAPEKDVD GFHFINVGKL GTGEVETAFV PCTPAGAMIM 150
    IERVHGRDLS GLNAVVIGRS NIVGKPMFNL LLAANATVTV AHSRTKDLPA 200
    IARNADILVA AVGRPQMVKG DWVKPGATVI DVGINRIPAP ERGEGKTRLV 250
    GDVDFAEAEK VAGAITPVPG GVGPMTIAML MANTLTAACR SAGMKKPVF 299
    Length:299
    Mass (Da):31,231
    Last modified:February 7, 2006 - v1
    Checksum:i7446B7B964FB967A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12623.1.
    RefSeqiYP_418651.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12623; CAJ12623; BAB2_0457.
    GeneIDi3828226.
    KEGGibmf:BAB2_0457.
    PATRICi17848454. VBIBruMel86222_2754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12623.1 .
    RefSeqi YP_418651.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YL33.
    SMRi Q2YL33. Positions 2-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0457.

    Proteomic databases

    PRIDEi Q2YL33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12623 ; CAJ12623 ; BAB2_0457 .
    GeneIDi 3828226.
    KEGGi bmf:BAB2_0457.
    PATRICi 17848454. VBIBruMel86222_2754.

    Phylogenomic databases

    eggNOGi COG0190.
    HOGENOMi HOG000218242.
    KOi K01491.
    OMAi MAGNDES.
    OrthoDBi EOG6K6VBB.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci BABO359391:GKDV-2702-MONOMER.
    BMEL359391:GJOQ-2702-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01576. THF_DHG_CYH.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00085. THFDHDRGNASE.
    PROSITEi PS00766. THF_DHG_CYH_1. 1 hit.
    PS00767. THF_DHG_CYH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiFOLD_BRUA2
    AccessioniPrimary (citable) accession number: Q2YL33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3