Reviewed, UniProtKB/Swiss-Prot Q2YKW2 (AHPD_BRUA2)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	BAB2_0532

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359477
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YKW2-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: D8E719C8EBB56ED5	FASTA	175	18,783
	10 20 30 40 50 60 MSIDDLKSKI PDFAKDVRLN LSSMASDETL TPQQKYGLFV ACGIASRNAD VRKALVAEAA 70 80 90 100 110 120 GKVDASVIQA AKAAASIMGM NNVYYRFVHL ASNKDYRTMP ARLRMNVISN PGVDKIDFEL 130 140 150 160 170 WSLAVSAING CGMCIDAHED VLRKANVTAE AIQAAVRFAS IIQSAAIALE AADTE

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040265 Genomic DNA. Translation: CAJ12698.1.
RefSeq	YP_418722.1.
3D structure databases
SMR	Q2YKW2. Positions 4-173.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YKW2.
Genome annotation databases
GeneID	3827507.
GenomeReviews	Gene locus BAB2_0532 in contig AM040265_GR.
KEGG	bmf:BAB2_0532.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2128.
HOGENOM	HBG414634.
OMA	RAGLRMN.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB2_0532-MONOMER.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_BRUA2

Accession

Primary (citable) accession number: Q2YKW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	February 7, 2006
Last modified:	February 9, 2010
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)