Q2YKL4 (GATC_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Short name=Asp/Glu-ADT subunit C
EC=6.3.5.-

Gene names

Name:	gatC
Ordered Locus Names:	BAB2_0645

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) By similarity. HAMAP-Rule MF_00122
Catalytic activity	ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. HAMAP-Rule MF_00122 ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate. HAMAP-Rule MF_00122
Subunit structure	Heterotrimer of A, B and C subunits By similarity.
Sequence similarities	Belongs to the GatC family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	regulation of translational fidelity Inferred from electronic annotation. Source: InterPro translation Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 95	95	Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C HAMAP-Rule MF_00122		PRO_1000016080

Sequences

	Sequence		Length	Mass (Da)
	Q2YKL4 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: AFCEDB571ACAB124	FASTA	95	10,303
	10 20 30 40 50 60 MSVDISTVKR VAHLARIAVS EDDAERMTGE LNAILGFVEQ LNEVDVEGIE PMTSVTPMKM 70 80 90 RMREDKVTDG GIAAAVVANA PVTEDNFFVV PKVVE

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040265 Genomic DNA. Translation: CAJ12811.1.
RefSeq	YP_418820.1. NC_007624.1.
3D structure databases
ProteinModelPortal	Q2YKL4.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0645.
Proteomic databases
PRIDE	Q2YKL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12811; CAJ12811; BAB2_0645.
GeneID	3828231.
KEGG	bmf:BAB2_0645.
PATRIC	17848833. VBIBruMel86222_2939.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0721.
HOGENOM	HOG000017522.
KO	K02435.
OMA	SVTPMAM.
ProtClustDB	PRK00034.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-2895-MONOMER.
Family and domain databases
HAMAP	MF_00122. GatC.
InterPro	IPR003837. Asp/Glu-ADT_csu. [Graphical view]
Pfam	PF02686. Glu-tRNAGln. 1 hit. [Graphical view]
TIGRFAMs	TIGR00135. gatC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GATC_BRUA2

Accession

Primary (citable) accession number: Q2YKL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program