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Q2YKL3

- GATA_BRUA2

UniProt

Q2YKL3 - GATA_BRUA2

Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791Charge relay systemUniRule annotation
    Active sitei159 – 1591Charge relay systemUniRule annotation
    Active sitei183 – 1831Acyl-ester intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2896-MONOMER.
    BMEL359391:GJOQ-2896-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
    Short name:
    Glu-ADT subunit AUniRule annotation
    Gene namesi
    Name:gatAUniRule annotation
    Ordered Locus Names:BAB2_0646
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Glutamyl-tRNA(Gln) amidotransferase subunit APRO_0000241078Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of A, B and C subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB2_0646.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YKL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the amidase family. GatA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0154.
    HOGENOMiHOG000116699.
    KOiK02433.
    OMAiTRGWKST.
    OrthoDBiEOG61P6R9.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    HAMAPiMF_00120. GatA.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 1 hit.
    TIGRFAMsiTIGR00132. gatA. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YKL3-1 [UniParc]FASTAAdd to Basket

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    MSELTALTIA EARDKLKAKA ITATELTDAY LSAIDAANDA INAYVAVTHD    50
    QARSMAKASD ERIAKGEAGA LEGIPLGVKD LFATKGVHTQ ACSHILDGFK 100
    PEYESTVTAN LWADGAVMLG KLNMDEVAMG SSNETSYYGP VKNPWRAKGS 150
    NADLVPGGSS GGSAAAVAAH LCAGATATDT GGSIRQPAAF TGTVGIKPTY 200
    GRVSRWGTVA FASSLDQAGP IARDVRDAAI LMKSMASLDL KDTTSVDLPV 250
    PDYEAALGRS VKGMKIGIPR EYRVDGMPGE IEELWQKGIQ YLKDAGAEIV 300
    DISLPHTKYA LPAYYIVAPA EASSNLARYD GVRYGLRVPG KDIADMYEQT 350
    RAAGFGKEVK RRIMIGTYVL SAGYYDAYYL RAQKVRTLIK KDFEDVFAKG 400
    VDAILTPATP SAAFGLADEV LANDPVKMYL NDIFTVTVNM AGLPGIAVPA 450
    GLNGQGLPLG LQLIGRPFEE ETLFQAAHVI EQAAGRFTPA KWW 493
    Length:493
    Mass (Da):52,399
    Last modified:February 7, 2006 - v1
    Checksum:i9830C28DEC567BD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12812.1.
    RefSeqiYP_418821.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12812; CAJ12812; BAB2_0646.
    GeneIDi3828230.
    KEGGibmf:BAB2_0646.
    PATRICi17848835. VBIBruMel86222_2940.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12812.1 .
    RefSeqi YP_418821.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YKL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12812 ; CAJ12812 ; BAB2_0646 .
    GeneIDi 3828230.
    KEGGi bmf:BAB2_0646.
    PATRICi 17848835. VBIBruMel86222_2940.

    Phylogenomic databases

    eggNOGi COG0154.
    HOGENOMi HOG000116699.
    KOi K02433.
    OMAi TRGWKST.
    OrthoDBi EOG61P6R9.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2896-MONOMER.
    BMEL359391:GJOQ-2896-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    HAMAPi MF_00120. GatA.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 1 hit.
    TIGRFAMsi TIGR00132. gatA. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiGATA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YKL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3