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Q2YKK7

- LOVHK_BRUA2

UniProt

Q2YKK7 - LOVHK_BRUA2

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Protein

Blue-light-activated histidine kinase

Gene
BAB2_0652
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light. Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host By similarity. This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages, as it is required for optimal replication of bacteria inside macrophages.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro
  3. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Photoreceptor protein, Receptor, Transferase

Keywords - Biological processi

Sensory transduction, Virulence

Keywords - Ligandi

ATP-binding, Chromophore, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2902-MONOMER.
BMEL359391:GJOQ-2902-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Blue-light-activated histidine kinase (EC:2.7.13.3)
Alternative name(s):
BA-LOV-histidine kinase
Short name:
BA-LOV-HK
Gene namesi
Ordered Locus Names:BAB2_0652
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi69 – 691C → A: Loss of ability to multiply efficiently inside host macrophages. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Blue-light-activated histidine kinasePRO_0000361282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691S-4a-FMN cysteine By similarity
Modified residuei288 – 2881Phosphohistidine; by autocatalysis By similarity

Post-translational modificationi

FMN binds covalently to cysteine after exposure to blue light and this bond is spontaneously broken in the dark By similarity.

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Induced after invasion of host macrophages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0652.

Structurei

3D structure databases

ProteinModelPortaliQ2YKK7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 9375PASAdd
BLAST
Domaini93 – 14755PAC 1Add
BLAST
Domaini232 – 28150PAC 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 34183HWE histidine kinase domainAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000032444.
KOiK00936.
OrthoDBiEOG6TBHBG.

Family and domain databases

InterProiIPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013655. PAS_fold_3.
IPR011102. Sig_transdc_His_kinase_HWE.
[Graphical view]
PfamiPF07536. HWE_HK. 1 hit.
PF08447. PAS_3. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
SMARTiSM00911. HWE_HK. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 2 hits.
PROSITEiPS50113. PAC. 2 hits.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YKK7-1 [UniParc]FASTAAdd to Basket

« Hide

MAIDLRPFIP FGRGALSQAT DPFRAAVEFT LMPMLITNPH LPDNPIVFAN    50
PAFLKLTGYE ADEVMGRNCR FLQGHGTDPA HVRAIKSAIA AEKPIDIDII 100
NYKKSGEAFW NRLHISPVHN ANGRLQHFVS SQLDVTLELS RLVELEKERK 150
TLSIETARSK DQLDYIVEVA NIGFWTREFY SGKMTCSAEC RRIYGFTPDE 200
PVHFDTILDL VVLEDRMTVV QKAHQAVTGE PYSIEYRIVT RLGETRWLET 250
RAKALTGENP LVLGIVQDVT ERKKAEANKA LVSREIAHRF KNSMAMVQSI 300
ANQTLRNTYD PEQANRLFSE RLRALSQAHD MLLKENWAGA TIQQICATAL 350
APFNSTFANR IHMSGPHLLV SDRVTVALSL AFYELATNAV KYGALSNEKG 400
VINITWAIME DKGEKKFHMR WAESRGPEVM QPARRGFGQR LLHSVLAEEL 450
KAKCDVEFAA SGLLIDVLAP ITPEVFPGMG HNVPEQRIA 489
Length:489
Mass (Da):54,874
Last modified:January 20, 2009 - v2
Checksum:i6F2A04467FB26C5B
GO

Sequence cautioni

The sequence CAJ12818.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12818.1. Different initiation.
RefSeqiYP_418827.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12818; CAJ12818; BAB2_0652.
GeneIDi3827969.
KEGGibmf:BAB2_0652.
PATRICi17848847. VBIBruMel86222_2946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12818.1 . Different initiation.
RefSeqi YP_418827.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YKK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12818 ; CAJ12818 ; BAB2_0652 .
GeneIDi 3827969.
KEGGi bmf:BAB2_0652.
PATRICi 17848847. VBIBruMel86222_2946.

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000032444.
KOi K00936.
OrthoDBi EOG6TBHBG.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2902-MONOMER.
BMEL359391:GJOQ-2902-MONOMER.

Family and domain databases

InterProi IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013655. PAS_fold_3.
IPR011102. Sig_transdc_His_kinase_HWE.
[Graphical view ]
Pfami PF07536. HWE_HK. 1 hit.
PF08447. PAS_3. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
SMARTi SM00911. HWE_HK. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 2 hits.
TIGRFAMsi TIGR00229. sensory_box. 2 hits.
PROSITEi PS50113. PAC. 2 hits.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. Cited for: ROLE IN VIRULENCE, INDUCTION, MUTAGENESIS OF CYS-69.

Entry informationi

Entry nameiLOVHK_BRUA2
AccessioniPrimary (citable) accession number: Q2YKK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: May 14, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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