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Q2YKK7

- LOVHK_BRUA2

UniProt

Q2YKK7 - LOVHK_BRUA2

Protein

Blue-light-activated histidine kinase

Gene

BAB2_0652

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light. Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host By similarity. This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages, as it is required for optimal replication of bacteria inside macrophages.By similarity1 Publication

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorelay sensor kinase activity Source: InterPro
    3. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Photoreceptor protein, Receptor, Transferase

    Keywords - Biological processi

    Sensory transduction, Virulence

    Keywords - Ligandi

    ATP-binding, Chromophore, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2902-MONOMER.
    BMEL359391:GJOQ-2902-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Blue-light-activated histidine kinase (EC:2.7.13.3)
    Alternative name(s):
    BA-LOV-histidine kinase
    Short name:
    BA-LOV-HK
    Gene namesi
    Ordered Locus Names:BAB2_0652
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi69 – 691C → A: Loss of ability to multiply efficiently inside host macrophages. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Blue-light-activated histidine kinasePRO_0000361282Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei69 – 691S-4a-FMN cysteineBy similarity
    Modified residuei288 – 2881Phosphohistidine; by autocatalysisBy similarity

    Post-translational modificationi

    FMN binds covalently to cysteine after exposure to blue light and this bond is spontaneously broken in the dark.By similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    Induced after invasion of host macrophages.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB2_0652.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YKK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 9375PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 14755PAC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini232 – 28150PAC 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni259 – 34183HWE histidine kinase domainAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PAC (PAS-associated C-terminal) domains.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000032444.
    KOiK00936.
    OrthoDBiEOG6TBHBG.

    Family and domain databases

    InterProiIPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR013655. PAS_fold_3.
    IPR011102. Sig_transdc_His_kinase_HWE.
    [Graphical view]
    PfamiPF07536. HWE_HK. 1 hit.
    PF08447. PAS_3. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    SMARTiSM00911. HWE_HK. 1 hit.
    SM00086. PAC. 2 hits.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 2 hits.
    TIGRFAMsiTIGR00229. sensory_box. 2 hits.
    PROSITEiPS50113. PAC. 2 hits.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YKK7-1 [UniParc]FASTAAdd to Basket

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    MAIDLRPFIP FGRGALSQAT DPFRAAVEFT LMPMLITNPH LPDNPIVFAN    50
    PAFLKLTGYE ADEVMGRNCR FLQGHGTDPA HVRAIKSAIA AEKPIDIDII 100
    NYKKSGEAFW NRLHISPVHN ANGRLQHFVS SQLDVTLELS RLVELEKERK 150
    TLSIETARSK DQLDYIVEVA NIGFWTREFY SGKMTCSAEC RRIYGFTPDE 200
    PVHFDTILDL VVLEDRMTVV QKAHQAVTGE PYSIEYRIVT RLGETRWLET 250
    RAKALTGENP LVLGIVQDVT ERKKAEANKA LVSREIAHRF KNSMAMVQSI 300
    ANQTLRNTYD PEQANRLFSE RLRALSQAHD MLLKENWAGA TIQQICATAL 350
    APFNSTFANR IHMSGPHLLV SDRVTVALSL AFYELATNAV KYGALSNEKG 400
    VINITWAIME DKGEKKFHMR WAESRGPEVM QPARRGFGQR LLHSVLAEEL 450
    KAKCDVEFAA SGLLIDVLAP ITPEVFPGMG HNVPEQRIA 489
    Length:489
    Mass (Da):54,874
    Last modified:January 20, 2009 - v2
    Checksum:i6F2A04467FB26C5B
    GO

    Sequence cautioni

    The sequence CAJ12818.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12818.1. Different initiation.
    RefSeqiYP_418827.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12818; CAJ12818; BAB2_0652.
    GeneIDi3827969.
    KEGGibmf:BAB2_0652.
    PATRICi17848847. VBIBruMel86222_2946.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12818.1 . Different initiation.
    RefSeqi YP_418827.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YKK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12818 ; CAJ12818 ; BAB2_0652 .
    GeneIDi 3827969.
    KEGGi bmf:BAB2_0652.
    PATRICi 17848847. VBIBruMel86222_2946.

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000032444.
    KOi K00936.
    OrthoDBi EOG6TBHBG.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2902-MONOMER.
    BMEL359391:GJOQ-2902-MONOMER.

    Family and domain databases

    InterProi IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR013655. PAS_fold_3.
    IPR011102. Sig_transdc_His_kinase_HWE.
    [Graphical view ]
    Pfami PF07536. HWE_HK. 1 hit.
    PF08447. PAS_3. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    SMARTi SM00911. HWE_HK. 1 hit.
    SM00086. PAC. 2 hits.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 2 hits.
    TIGRFAMsi TIGR00229. sensory_box. 2 hits.
    PROSITEi PS50113. PAC. 2 hits.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.
    2. Cited for: ROLE IN VIRULENCE, INDUCTION, MUTAGENESIS OF CYS-69.

    Entry informationi

    Entry nameiLOVHK_BRUA2
    AccessioniPrimary (citable) accession number: Q2YKK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3