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Q2YKK7

- LOVHK_BRUA2

UniProt

Q2YKK7 - LOVHK_BRUA2

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Protein

Blue-light-activated histidine kinase

Gene

BAB2_0652

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light. Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host (By similarity). This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages, as it is required for optimal replication of bacteria inside macrophages.By similarity1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro
  3. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Photoreceptor protein, Receptor, Transferase

Keywords - Biological processi

Sensory transduction, Virulence

Keywords - Ligandi

ATP-binding, Chromophore, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2902-MONOMER.
BMEL359391:GJOQ-2902-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Blue-light-activated histidine kinase (EC:2.7.13.3)
Alternative name(s):
BA-LOV-histidine kinase
Short name:
BA-LOV-HK
Gene namesi
Ordered Locus Names:BAB2_0652
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi69 – 691C → A: Loss of ability to multiply efficiently inside host macrophages. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Blue-light-activated histidine kinasePRO_0000361282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691S-4a-FMN cysteineBy similarity
Modified residuei288 – 2881Phosphohistidine; by autocatalysisBy similarity

Post-translational modificationi

FMN binds covalently to cysteine after exposure to blue light and this bond is spontaneously broken in the dark.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Induced after invasion of host macrophages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0652.

Structurei

3D structure databases

ProteinModelPortaliQ2YKK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 9375PASPROSITE-ProRule annotationAdd
BLAST
Domaini93 – 14755PAC 1PROSITE-ProRule annotationAdd
BLAST
Domaini232 – 28150PAC 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 34183HWE histidine kinase domainAdd
BLAST

Sequence similaritiesi

Contains 2 PAC (PAS-associated C-terminal) domains.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000032444.
KOiK00936.
OrthoDBiEOG6TBHBG.

Family and domain databases

InterProiIPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013655. PAS_fold_3.
IPR011102. Sig_transdc_His_kinase_HWE.
[Graphical view]
PfamiPF07536. HWE_HK. 1 hit.
PF08447. PAS_3. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
SMARTiSM00911. HWE_HK. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 2 hits.
PROSITEiPS50113. PAC. 2 hits.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YKK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIDLRPFIP FGRGALSQAT DPFRAAVEFT LMPMLITNPH LPDNPIVFAN
60 70 80 90 100
PAFLKLTGYE ADEVMGRNCR FLQGHGTDPA HVRAIKSAIA AEKPIDIDII
110 120 130 140 150
NYKKSGEAFW NRLHISPVHN ANGRLQHFVS SQLDVTLELS RLVELEKERK
160 170 180 190 200
TLSIETARSK DQLDYIVEVA NIGFWTREFY SGKMTCSAEC RRIYGFTPDE
210 220 230 240 250
PVHFDTILDL VVLEDRMTVV QKAHQAVTGE PYSIEYRIVT RLGETRWLET
260 270 280 290 300
RAKALTGENP LVLGIVQDVT ERKKAEANKA LVSREIAHRF KNSMAMVQSI
310 320 330 340 350
ANQTLRNTYD PEQANRLFSE RLRALSQAHD MLLKENWAGA TIQQICATAL
360 370 380 390 400
APFNSTFANR IHMSGPHLLV SDRVTVALSL AFYELATNAV KYGALSNEKG
410 420 430 440 450
VINITWAIME DKGEKKFHMR WAESRGPEVM QPARRGFGQR LLHSVLAEEL
460 470 480
KAKCDVEFAA SGLLIDVLAP ITPEVFPGMG HNVPEQRIA
Length:489
Mass (Da):54,874
Last modified:January 20, 2009 - v2
Checksum:i6F2A04467FB26C5B
GO

Sequence cautioni

The sequence CAJ12818.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12818.1. Different initiation.
RefSeqiYP_418827.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12818; CAJ12818; BAB2_0652.
GeneIDi3827969.
KEGGibmf:BAB2_0652.
PATRICi17848847. VBIBruMel86222_2946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12818.1 . Different initiation.
RefSeqi YP_418827.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YKK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12818 ; CAJ12818 ; BAB2_0652 .
GeneIDi 3827969.
KEGGi bmf:BAB2_0652.
PATRICi 17848847. VBIBruMel86222_2946.

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000032444.
KOi K00936.
OrthoDBi EOG6TBHBG.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2902-MONOMER.
BMEL359391:GJOQ-2902-MONOMER.

Family and domain databases

InterProi IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013655. PAS_fold_3.
IPR011102. Sig_transdc_His_kinase_HWE.
[Graphical view ]
Pfami PF07536. HWE_HK. 1 hit.
PF08447. PAS_3. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
SMARTi SM00911. HWE_HK. 1 hit.
SM00086. PAC. 2 hits.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 2 hits.
TIGRFAMsi TIGR00229. sensory_box. 2 hits.
PROSITEi PS50113. PAC. 2 hits.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. Cited for: ROLE IN VIRULENCE, INDUCTION, MUTAGENESIS OF CYS-69.

Entry informationi

Entry nameiLOVHK_BRUA2
AccessioniPrimary (citable) accession number: Q2YKK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: October 1, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3