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Protein

Homoserine O-acetyltransferase

Gene

metAA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metAA)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei111Important for acyl-CoA specificity1
Active sitei142Acyl-thioester intermediate1
Binding sitei163Substrate1
Binding sitei192Substrate1
Sitei192Important for substrate specificity1
Active sitei235Proton acceptor1
Active sitei2371
Binding sitei249Substrate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferase (EC:2.3.1.31)
Short name:
HAT
Alternative name(s):
Homoserine transacetylase
Short name:
HTA
Gene namesi
Name:metAA
Ordered Locus Names:BAB2_0751
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000218031 – 306Homoserine O-acetyltransferaseAdd BLAST306

Structurei

3D structure databases

ProteinModelPortaliQ2YKB2.
SMRiQ2YKB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MetA family.

Phylogenomic databases

HOGENOMiHOG000115049.
KOiK00651.
OMAiCWAAHAA.

Family and domain databases

CDDicd03131. GATase1_HTS. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. MetA_acyltransf. 1 hit.
InterProiView protein in InterPro
IPR029062. Class_I_gatase-like.
IPR005697. HST_MetA.
IPR033752. MetA_family.
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiView protein in Pfam
PF04204. HTS. 1 hit.
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YKB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKIPDDLP ATSVLEAEGV MVMREADAVR QDIRPLRIGL LNLMPNKVTT
60 70 80 90 100
ETQIARLLGA TPLQVELTLV RMTNHVARHT PADHMLSFYC PWEEVNDQRF
110 120 130 140 150
DGFVITGAPV ERLPFEEVTY WDEMRRVFDW TQSHVHRTLN ICWAAQAAVY
160 170 180 190 200
HFHGMKKYDL PAKASGVFRQ RSLVPASPYL RGFSDDFAIP VSRWTEVRKS
210 220 230 240 250
DIPADSGLKV LVDSTETGLC LLDDPRHRSL HMFNHVEYDT TSLADEYFRD
260 270 280 290 300
IQVQPEAKVP VNYFPGDDAK RPPENRWRSH AHLLFGNWIN EMYQSTPYDI

ERIGKV
Length:306
Mass (Da):35,245
Last modified:February 7, 2006 - v1
Checksum:iE942A97E01C13E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12917.1.
RefSeqiWP_002966142.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ12917; CAJ12917; BAB2_0751.
KEGGibmf:BAB2_0751.
PATRICifig|359391.11.peg.443.

Similar proteinsi

Entry informationi

Entry nameiMETAA_BRUA2
AccessioniPrimary (citable) accession number: Q2YKB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: October 25, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families