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Q2YKB2

- META_BRUA2

UniProt

Q2YKB2 - META_BRUA2

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Protein

Homoserine O-succinyltransferase

Gene
metA, BAB2_0751
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421 Reviewed prediction

GO - Molecular functioni

  1. homoserine O-succinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3003-MONOMER.
BMEL359391:GJOQ-3003-MONOMER.
UniPathwayiUPA00051; UER00075.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-succinyltransferase (EC:2.3.1.46)
Alternative name(s):
Homoserine O-transsuccinylase
Short name:
HTS
Gene namesi
Name:metA
Ordered Locus Names:BAB2_0751
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Homoserine O-succinyltransferaseUniRule annotationPRO_1000021803Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0751.

Structurei

3D structure databases

ProteinModelPortaliQ2YKB2.

Family & Domainsi

Sequence similaritiesi

Belongs to the HTS family.

Phylogenomic databases

eggNOGiCOG1897.
HOGENOMiHOG000115049.
KOiK00651.
OMAiFEDVIYW.
OrthoDBiEOG61P6ST.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr.
InterProiIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
[Graphical view]
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiPF04204. HTS. 1 hit.
[Graphical view]
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
ProDomiPD037892. Homserine_suc_trans. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YKB2-1 [UniParc]FASTAAdd to Basket

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MPIKIPDDLP ATSVLEAEGV MVMREADAVR QDIRPLRIGL LNLMPNKVTT    50
ETQIARLLGA TPLQVELTLV RMTNHVARHT PADHMLSFYC PWEEVNDQRF 100
DGFVITGAPV ERLPFEEVTY WDEMRRVFDW TQSHVHRTLN ICWAAQAAVY 150
HFHGMKKYDL PAKASGVFRQ RSLVPASPYL RGFSDDFAIP VSRWTEVRKS 200
DIPADSGLKV LVDSTETGLC LLDDPRHRSL HMFNHVEYDT TSLADEYFRD 250
IQVQPEAKVP VNYFPGDDAK RPPENRWRSH AHLLFGNWIN EMYQSTPYDI 300
ERIGKV 306
Length:306
Mass (Da):35,245
Last modified:February 7, 2006 - v1
Checksum:iE942A97E01C13E47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12917.1.
RefSeqiYP_418922.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12917; CAJ12917; BAB2_0751.
GeneIDi3827179.
KEGGibmf:BAB2_0751.
PATRICi17849050. VBIBruMel86222_3045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12917.1 .
RefSeqi YP_418922.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YKB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12917 ; CAJ12917 ; BAB2_0751 .
GeneIDi 3827179.
KEGGi bmf:BAB2_0751.
PATRICi 17849050. VBIBruMel86222_3045.

Phylogenomic databases

eggNOGi COG1897.
HOGENOMi HOG000115049.
KOi K00651.
OMAi FEDVIYW.
OrthoDBi EOG61P6ST.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00075 .
BioCyci BABO359391:GKDV-3003-MONOMER.
BMEL359391:GJOQ-3003-MONOMER.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
HAMAPi MF_00295. Homoser_O_succinyltr.
InterProi IPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
[Graphical view ]
PANTHERi PTHR20919. PTHR20919. 1 hit.
Pfami PF04204. HTS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000450. H_ser_succinyltr. 1 hit.
ProDomi PD037892. Homserine_suc_trans. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR01001. metA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiMETA_BRUA2
AccessioniPrimary (citable) accession number: Q2YKB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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