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Protein

Homoserine O-succinyltransferase

Gene

metA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3003-MONOMER.
BMEL359391:GJOQ-3003-MONOMER.
UniPathwayiUPA00051; UER00075.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-succinyltransferaseUniRule annotation (EC:2.3.1.46UniRule annotation)
Alternative name(s):
Homoserine O-transsuccinylaseUniRule annotation
Short name:
HTSUniRule annotation
Gene namesi
Name:metAUniRule annotation
Ordered Locus Names:BAB2_0751
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Homoserine O-succinyltransferasePRO_1000021803Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0751.

Structurei

3D structure databases

ProteinModelPortaliQ2YKB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HTS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1897.
HOGENOMiHOG000115049.
KOiK00651.
OMAiWRSHRNL.
OrthoDBiEOG61P6ST.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr.
InterProiIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
[Graphical view]
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiPF04204. HTS. 1 hit.
[Graphical view]
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
ProDomiPD037892. Homserine_suc_trans. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YKB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKIPDDLP ATSVLEAEGV MVMREADAVR QDIRPLRIGL LNLMPNKVTT
60 70 80 90 100
ETQIARLLGA TPLQVELTLV RMTNHVARHT PADHMLSFYC PWEEVNDQRF
110 120 130 140 150
DGFVITGAPV ERLPFEEVTY WDEMRRVFDW TQSHVHRTLN ICWAAQAAVY
160 170 180 190 200
HFHGMKKYDL PAKASGVFRQ RSLVPASPYL RGFSDDFAIP VSRWTEVRKS
210 220 230 240 250
DIPADSGLKV LVDSTETGLC LLDDPRHRSL HMFNHVEYDT TSLADEYFRD
260 270 280 290 300
IQVQPEAKVP VNYFPGDDAK RPPENRWRSH AHLLFGNWIN EMYQSTPYDI

ERIGKV
Length:306
Mass (Da):35,245
Last modified:February 7, 2006 - v1
Checksum:iE942A97E01C13E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12917.1.
RefSeqiWP_002966142.1. NZ_KN046823.1.
YP_418922.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12917; CAJ12917; BAB2_0751.
GeneIDi3827179.
KEGGibmf:BAB2_0751.
PATRICi17849050. VBIBruMel86222_3045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12917.1.
RefSeqiWP_002966142.1. NZ_KN046823.1.
YP_418922.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YKB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12917; CAJ12917; BAB2_0751.
GeneIDi3827179.
KEGGibmf:BAB2_0751.
PATRICi17849050. VBIBruMel86222_3045.

Phylogenomic databases

eggNOGiCOG1897.
HOGENOMiHOG000115049.
KOiK00651.
OMAiWRSHRNL.
OrthoDBiEOG61P6ST.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00075.
BioCyciBABO359391:GKDV-3003-MONOMER.
BMEL359391:GJOQ-3003-MONOMER.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_00295. Homoser_O_succinyltr.
InterProiIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
[Graphical view]
PANTHERiPTHR20919. PTHR20919. 1 hit.
PfamiPF04204. HTS. 1 hit.
[Graphical view]
PIRSFiPIRSF000450. H_ser_succinyltr. 1 hit.
ProDomiPD037892. Homserine_suc_trans. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01001. metA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiMETA_BRUA2
AccessioniPrimary (citable) accession number: Q2YKB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 27, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.