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Q2YKB2 (META_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine O-succinyltransferase

EC=2.3.1.46
Alternative name(s):
Homoserine O-transsuccinylase
Short name=HTS
Gene names
Name:metA
Ordered Locus Names:BAB2_0751
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine. HAMAP-Rule MF_00295

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1. HAMAP-Rule MF_00295

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00295.

Sequence similarities

Belongs to the HTS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Methionine biosynthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhomoserine O-succinyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Homoserine O-succinyltransferase HAMAP-Rule MF_00295
PRO_1000021803

Sites

Active site1421 Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YKB2 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: E942A97E01C13E47

FASTA30635,245
        10         20         30         40         50         60 
MPIKIPDDLP ATSVLEAEGV MVMREADAVR QDIRPLRIGL LNLMPNKVTT ETQIARLLGA 

        70         80         90        100        110        120 
TPLQVELTLV RMTNHVARHT PADHMLSFYC PWEEVNDQRF DGFVITGAPV ERLPFEEVTY 

       130        140        150        160        170        180 
WDEMRRVFDW TQSHVHRTLN ICWAAQAAVY HFHGMKKYDL PAKASGVFRQ RSLVPASPYL 

       190        200        210        220        230        240 
RGFSDDFAIP VSRWTEVRKS DIPADSGLKV LVDSTETGLC LLDDPRHRSL HMFNHVEYDT 

       250        260        270        280        290        300 
TSLADEYFRD IQVQPEAKVP VNYFPGDDAK RPPENRWRSH AHLLFGNWIN EMYQSTPYDI 


ERIGKV 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040265 Genomic DNA. Translation: CAJ12917.1.
RefSeqYP_418922.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YKB2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12917; CAJ12917; BAB2_0751.
GeneID3827179.
KEGGbmf:BAB2_0751.
PATRIC17849050. VBIBruMel86222_3045.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1897.
HOGENOMHOG000115049.
KOK00651.
OMAFEDVIYW.
OrthoDBEOG61P6ST.

Enzyme and pathway databases

BioCycBABO359391:GKDV-3003-MONOMER.
BMEL359391:GJOQ-3003-MONOMER.
UniPathwayUPA00051; UER00075.

Family and domain databases

Gene3D3.40.50.880. 1 hit.
HAMAPMF_00295. Homoser_O_succinyltr.
InterProIPR029062. Class_I_gatase-like.
IPR005697. Homserine_suc_trans.
[Graphical view]
PANTHERPTHR20919. PTHR20919. 1 hit.
PfamPF04204. HTS. 1 hit.
[Graphical view]
PIRSFPIRSF000450. H_ser_succinyltr. 1 hit.
ProDomPD037892. Homserine_suc_trans. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF52317. SSF52317. 1 hit.
TIGRFAMsTIGR01001. metA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETA_BRUA2
AccessionPrimary (citable) accession number: Q2YKB2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names