Q2YKB2 (META_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine O-succinyltransferase
EC=2.3.1.46

Alternative name(s):
Homoserine O-transsuccinylase
Short name=HTS

Gene names

Name:	metA
Ordered Locus Names:	BAB2_0751

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine. HAMAP-Rule MF_00295
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1. HAMAP-Rule MF_00295
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HTS family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	homoserine O-succinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Homoserine O-succinyltransferase HAMAP-Rule MF_00295		PRO_1000021803
Sites
	Active site	142	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YKB2 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: E942A97E01C13E47	FASTA	306	35,245
	10 20 30 40 50 60 MPIKIPDDLP ATSVLEAEGV MVMREADAVR QDIRPLRIGL LNLMPNKVTT ETQIARLLGA 70 80 90 100 110 120 TPLQVELTLV RMTNHVARHT PADHMLSFYC PWEEVNDQRF DGFVITGAPV ERLPFEEVTY 130 140 150 160 170 180 WDEMRRVFDW TQSHVHRTLN ICWAAQAAVY HFHGMKKYDL PAKASGVFRQ RSLVPASPYL 190 200 210 220 230 240 RGFSDDFAIP VSRWTEVRKS DIPADSGLKV LVDSTETGLC LLDDPRHRSL HMFNHVEYDT 250 260 270 280 290 300 TSLADEYFRD IQVQPEAKVP VNYFPGDDAK RPPENRWRSH AHLLFGNWIN EMYQSTPYDI ERIGKV

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040265 Genomic DNA. Translation: CAJ12917.1.
RefSeq	YP_418922.1. NC_007624.1.
3D structure databases
HSSP	HSSP built from PDB template 2GHR based on UniProtKB Q72X44.
ProteinModelPortal	Q2YKB2.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0751.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12917; CAJ12917; BAB2_0751.
GeneID	3827179.
KEGG	bmf:BAB2_0751.
PATRIC	17849050. VBIBruMel86222_3045.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1897.
HOGENOM	HOG000115049.
KO	K00651.
OMA	WRSHRNL.
ProtClustDB	PRK05368.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-3003-MONOMER.
UniPathway	UPA00051; UER00075.
Family and domain databases
HAMAP	MF_00295. Homoser_O-succinyltr.
InterPro	IPR005697. Homserine_suc_trans. [Graphical view]
PANTHER	PTHR20919. PTHR20919. 1 hit.
Pfam	PF04204. HTS. 1 hit. [Graphical view]
PIRSF	PIRSF000450. H_ser_succinyltr. 1 hit.
ProDom	PD037892. Homserine_suc_trans. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01001. metA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

META_BRUA2

Accession

Primary (citable) accession number: Q2YKB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program