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Q2YK17

- GLSA_BRUA2

UniProt

Q2YK17 - GLSA_BRUA2

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Protein

Glutaminase

Gene
glsA, BAB2_0863
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671Substrate By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei162 – 1621Substrate By similarity
Binding sitei169 – 1691Substrate By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei245 – 2451Substrate By similarity
Binding sitei263 – 2631Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3115-MONOMER.
BMEL359391:GJOQ-3115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:BAB2_0863
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317GlutaminaseUniRule annotationPRO_1000048327Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB2_0863.

Structurei

3D structure databases

ProteinModelPortaliQ2YK17.
SMRiQ2YK17. Positions 5-309.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQCSVGVT.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YK17-1 [UniParc]FASTAAdd to Basket

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MSSSSDAIKA ALEKGRAAGL SATGGKNADY IPFLASVPSD LFGLAVVTAD    50
GQTFKTGDAD IAFAIESISK VFTLALVMEE IGPDSVREKV GADPTGLPFN 100
SVIALELHNG KSLSPLVNAG AIATASLVPG DTADARWNNI LECQCGFAGR 150
RLKLSNEVNQ SEQTTNFHNR AIAWLLYSAG TCYSDPMEAV DIYTRQCSTL 200
VTATDLATMG ATLAAGGVNP ISGKRMVSAG NVAPILVEMT MEGLYTALGD 250
WAYTVGLPGK SGVGGGIMAV VPGELAIAAF SPPLDPAGNS VKAMAAVAAV 300
ADSLGHNLYT TRGKVSS 317
Length:317
Mass (Da):32,463
Last modified:February 7, 2006 - v1
Checksum:iA5ED37D230E862BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ13029.1.
RefSeqiYP_419017.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ13029; CAJ13029; BAB2_0863.
GeneIDi3827366.
KEGGibmf:BAB2_0863.
PATRICi17849272. VBIBruMel86222_3155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ13029.1 .
RefSeqi YP_419017.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YK17.
SMRi Q2YK17. Positions 5-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ13029 ; CAJ13029 ; BAB2_0863 .
GeneIDi 3827366.
KEGGi bmf:BAB2_0863.
PATRICi 17849272. VBIBruMel86222_3155.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QCSVGVT.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-3115-MONOMER.
BMEL359391:GJOQ-3115-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiGLSA_BRUA2
AccessioniPrimary (citable) accession number: Q2YK17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi