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Protein

Glutaminase

Gene

glsA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671SubstrateUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei162 – 1621SubstrateUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Binding sitei193 – 1931SubstrateUniRule annotation
Binding sitei245 – 2451SubstrateUniRule annotation
Binding sitei263 – 2631Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3115-MONOMER.
BMEL359391:GJOQ-3115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:BAB2_0863
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317GlutaminasePRO_1000048327Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB2_0863.

Structurei

3D structure databases

ProteinModelPortaliQ2YK17.
SMRiQ2YK17. Positions 5-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YK17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSSDAIKA ALEKGRAAGL SATGGKNADY IPFLASVPSD LFGLAVVTAD
60 70 80 90 100
GQTFKTGDAD IAFAIESISK VFTLALVMEE IGPDSVREKV GADPTGLPFN
110 120 130 140 150
SVIALELHNG KSLSPLVNAG AIATASLVPG DTADARWNNI LECQCGFAGR
160 170 180 190 200
RLKLSNEVNQ SEQTTNFHNR AIAWLLYSAG TCYSDPMEAV DIYTRQCSTL
210 220 230 240 250
VTATDLATMG ATLAAGGVNP ISGKRMVSAG NVAPILVEMT MEGLYTALGD
260 270 280 290 300
WAYTVGLPGK SGVGGGIMAV VPGELAIAAF SPPLDPAGNS VKAMAAVAAV
310
ADSLGHNLYT TRGKVSS
Length:317
Mass (Da):32,463
Last modified:February 7, 2006 - v1
Checksum:iA5ED37D230E862BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ13029.1.
RefSeqiYP_419017.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ13029; CAJ13029; BAB2_0863.
GeneIDi3827366.
KEGGibmf:BAB2_0863.
PATRICi17849272. VBIBruMel86222_3155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ13029.1.
RefSeqiYP_419017.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YK17.
SMRiQ2YK17. Positions 5-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0863.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ13029; CAJ13029; BAB2_0863.
GeneIDi3827366.
KEGGibmf:BAB2_0863.
PATRICi17849272. VBIBruMel86222_3155.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiISKAFVF.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3115-MONOMER.
BMEL359391:GJOQ-3115-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiGLSA_BRUA2
AccessioniPrimary (citable) accession number: Q2YK17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.