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Protein

Glutamate decarboxylase

Gene

BAB2_0865

Organism
Brucella abortus (strain 2308)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3117-MONOMER.
BMEL359391:GJOQ-3117-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:BAB2_0865Imported
ORF Names:DK47_2170Imported
OrganismiBrucella abortus (strain 2308)Imported
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0865.

Structurei

3D structure databases

ProteinModelPortaliQ2YK15.
SMRiQ2YK15. Positions 1-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiICFRIKE.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YK15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCWHKFARYW DVEIREIPME PGRLFMGPEQ MLEAVDENTI GVVPTFGVTY
60 70 80 90 100
TGNYEFPEPL QDALDKLQKT KGLDIDIHVD AASGGFLAPF CAPDIPWDFR
110 120 130 140 150
LPRVKSISAS GHKYGLAPLG CGWVVWRDKE ALPEELIFNV DYLGGQVGTF
160 170 180 190 200
AINFSRPAGQ VISQYYEFMR LGREGYTKVQ QAAYRVAQYI AREIEPLGPY
210 220 230 240 250
EFICAGEEKG GIPAVCFRIR EGEDPGYSLY DLSERLRLTG WQVPAFALSG
260 270 280 290 300
KASDITVMRV MCRCGFEMDL AALFIRDFKA GIEFFKSHPS PKITPSMGTG

FHHT
Length:304
Mass (Da):34,178
Last modified:December 20, 2005 - v1
Checksum:iBAE4D3D1C11CB69F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ13031.1.
JMRZ01000004 Genomic DNA. Translation: KFJ53208.1.
RefSeqiYP_419019.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ13031; CAJ13031; BAB2_0865.
GeneIDi3827368.
KEGGibmf:BAB2_0865.
PATRICi17849278. VBIBruMel86222_3158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ13031.1.
JMRZ01000004 Genomic DNA. Translation: KFJ53208.1.
RefSeqiYP_419019.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YK15.
SMRiQ2YK15. Positions 1-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ13031; CAJ13031; BAB2_0865.
GeneIDi3827368.
KEGGibmf:BAB2_0865.
PATRICi17849278. VBIBruMel86222_3158.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiICFRIKE.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3117-MONOMER.
BMEL359391:GJOQ-3117-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2308Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2308Imported.

Entry informationi

Entry nameiQ2YK15_BRUA2
AccessioniPrimary (citable) accession number: Q2YK15
Entry historyi
Integrated into UniProtKB/TrEMBL: December 20, 2005
Last sequence update: December 20, 2005
Last modified: February 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.