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Q2YJM4

- UBIE_BRUA2

UniProt

Q2YJM4 - UBIE_BRUA2

Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene

ubiE

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

    Catalytic activityi

    A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
    S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
    2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis, Ubiquinone biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-3281-MONOMER.
    BMEL359391:GJOQ-3281-MONOMER.
    UniPathwayiUPA00079; UER00169.
    UPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)
    Alternative name(s):
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation
    Demethylmenaquinone methyltransferaseUniRule annotation
    Gene namesi
    Name:ubiEUniRule annotation
    Ordered Locus Names:BAB2_1026
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEPRO_1000088274Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB2_1026.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YJM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2226.
    HOGENOMiHOG000249463.
    KOiK03183.
    OMAiIWKRFTI.
    OrthoDBiEOG6M6JSB.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01813. UbiE_methyltran.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view]
    PfamiPF01209. Ubie_methyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YJM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQQNGNVNR VGAQDRVGAS GGMEHSFGFK AVDENEKQGL VNDVFHKVAK    50
    RYDIMNDLMS AGMHRVWKDA MVAWLAPSKR PGWTSLDVAG GTGDIAFRIV 100
    EASGRQAHVT ILDINGSMLG VGRERAIKKG LIDNLEFVEA NAEELPFEDN 150
    SFDAYTIAFG IRNVPHIDKA LSEAYRVLKP GGRFLCLEFS EVELPVLDKV 200
    YDEWSFRAIP RIGKMITGDA DSYSYLVESI RKFPKQQDFA AMIEKAGFER 250
    VSYRNFTGGI AALHSGWKL 269
    Length:269
    Mass (Da):29,898
    Last modified:February 7, 2006 - v1
    Checksum:i7A7D0AD3D80A7EC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ13192.1.
    RefSeqiYP_419160.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ13192; CAJ13192; BAB2_1026.
    GeneIDi3827246.
    KEGGibmf:BAB2_1026.
    PATRICi17849621. VBIBruMel86222_3326.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ13192.1 .
    RefSeqi YP_419160.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YJM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_1026.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ13192 ; CAJ13192 ; BAB2_1026 .
    GeneIDi 3827246.
    KEGGi bmf:BAB2_1026.
    PATRICi 17849621. VBIBruMel86222_3326.

    Phylogenomic databases

    eggNOGi COG2226.
    HOGENOMi HOG000249463.
    KOi K03183.
    OMAi IWKRFTI.
    OrthoDBi EOG6M6JSB.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00169 .
    UPA00232 .
    BioCyci BABO359391:GKDV-3281-MONOMER.
    BMEL359391:GJOQ-3281-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01813. UbiE_methyltran.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view ]
    Pfami PF01209. Ubie_methyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiUBIE_BRUA2
    AccessioniPrimary (citable) accession number: Q2YJM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3