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Q2YJM4 (UBIE_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

EC=2.1.1.163
EC=2.1.1.201
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase
Gene names
Name:ubiE
Ordered Locus Names:BAB2_1026
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity. HAMAP-Rule MF_01813

Catalytic activity

A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine. HAMAP-Rule MF_01813

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. HAMAP-Rule MF_01813

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8. HAMAP-Rule MF_01813

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01813

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
Ubiquinone biosynthesis
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

ubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE HAMAP-Rule MF_01813
PRO_1000088274

Sequences

Sequence LengthMass (Da)Tools
Q2YJM4 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 7A7D0AD3D80A7EC4

FASTA26929,898
        10         20         30         40         50         60 
MSQQNGNVNR VGAQDRVGAS GGMEHSFGFK AVDENEKQGL VNDVFHKVAK RYDIMNDLMS 

        70         80         90        100        110        120 
AGMHRVWKDA MVAWLAPSKR PGWTSLDVAG GTGDIAFRIV EASGRQAHVT ILDINGSMLG 

       130        140        150        160        170        180 
VGRERAIKKG LIDNLEFVEA NAEELPFEDN SFDAYTIAFG IRNVPHIDKA LSEAYRVLKP 

       190        200        210        220        230        240 
GGRFLCLEFS EVELPVLDKV YDEWSFRAIP RIGKMITGDA DSYSYLVESI RKFPKQQDFA 

       250        260 
AMIEKAGFER VSYRNFTGGI AALHSGWKL 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040265 Genomic DNA. Translation: CAJ13192.1.
RefSeqYP_419160.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YJM4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_1026.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ13192; CAJ13192; BAB2_1026.
GeneID3827246.
KEGGbmf:BAB2_1026.
PATRIC17849621. VBIBruMel86222_3326.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2226.
HOGENOMHOG000249463.
KOK03183.
OMAIWKRFTI.
OrthoDBEOG6M6JSB.
ProtClustDBPRK00216.

Enzyme and pathway databases

BioCycBABO359391:GKDV-3281-MONOMER.
BMEL359391:GJOQ-3281-MONOMER.
UniPathwayUPA00079; UER00169.
UPA00232.

Family and domain databases

HAMAPMF_01813. UbiE_methyltran.
InterProIPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIE_BRUA2
AccessionPrimary (citable) accession number: Q2YJM4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: March 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names