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Q2YJM4

- UBIE_BRUA2

UniProt

Q2YJM4 - UBIE_BRUA2

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Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene

ubiE

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
  2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis, Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3281-MONOMER.
BMEL359391:GJOQ-3281-MONOMER.
UniPathwayiUPA00079; UER00169.
UPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation
Demethylmenaquinone methyltransferaseUniRule annotation
Gene namesi
Name:ubiEUniRule annotation
Ordered Locus Names:BAB2_1026
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEPRO_1000088274Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_1026.

Structurei

3D structure databases

ProteinModelPortaliQ2YJM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2226.
HOGENOMiHOG000249463.
KOiK03183.
OMAiIWKRFTI.
OrthoDBiEOG6M6JSB.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. UbiE_methyltran.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YJM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQQNGNVNR VGAQDRVGAS GGMEHSFGFK AVDENEKQGL VNDVFHKVAK
60 70 80 90 100
RYDIMNDLMS AGMHRVWKDA MVAWLAPSKR PGWTSLDVAG GTGDIAFRIV
110 120 130 140 150
EASGRQAHVT ILDINGSMLG VGRERAIKKG LIDNLEFVEA NAEELPFEDN
160 170 180 190 200
SFDAYTIAFG IRNVPHIDKA LSEAYRVLKP GGRFLCLEFS EVELPVLDKV
210 220 230 240 250
YDEWSFRAIP RIGKMITGDA DSYSYLVESI RKFPKQQDFA AMIEKAGFER
260
VSYRNFTGGI AALHSGWKL
Length:269
Mass (Da):29,898
Last modified:February 7, 2006 - v1
Checksum:i7A7D0AD3D80A7EC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ13192.1.
RefSeqiYP_419160.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ13192; CAJ13192; BAB2_1026.
GeneIDi3827246.
KEGGibmf:BAB2_1026.
PATRICi17849621. VBIBruMel86222_3326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ13192.1 .
RefSeqi YP_419160.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YJM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_1026.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ13192 ; CAJ13192 ; BAB2_1026 .
GeneIDi 3827246.
KEGGi bmf:BAB2_1026.
PATRICi 17849621. VBIBruMel86222_3326.

Phylogenomic databases

eggNOGi COG2226.
HOGENOMi HOG000249463.
KOi K03183.
OMAi IWKRFTI.
OrthoDBi EOG6M6JSB.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00169 .
UPA00232 .
BioCyci BABO359391:GKDV-3281-MONOMER.
BMEL359391:GJOQ-3281-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01813. UbiE_methyltran.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view ]
Pfami PF01209. Ubie_methyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiUBIE_BRUA2
AccessioniPrimary (citable) accession number: Q2YJM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3