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Q2YJB2

- BHUA_BRUA2

UniProt

Q2YJB2 - BHUA_BRUA2

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Protein
Heme transporter BhuA
Gene
bhuA, BAB2_1150
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Heme transporter playing an important role in stationary-phase iron acquisition and required for maintenance of chronic infection in mice.1 Publication

GO - Molecular functioni

  1. receptor activity Source: InterPro
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciBABO359391:GKDV-3412-MONOMER.
BMEL359391:GJOQ-3412-MONOMER.

Protein family/group databases

TCDBi1.B.14.2.10. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme transporter BhuA
Alternative name(s):
Brucella heme uptake protein A
Gene namesi
Name:bhuA
Ordered Locus Names:BAB2_1150
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Subcellular locationi

Cell outer membrane By similarity

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

The mutant is unable to use hemin as an iron source but retains the ability to use ferric chloride and the siderophore 2,3-DHBA. Exhibits an accelerated loss of viability after 144 hours of culture in low-iron minimal medium. Exhibits significant attenuation in murine macrophages and is unable to maintain a chronic spleen infection in mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 661638Heme transporter BhuA
PRO_0000325857Add
BLAST

Expressioni

Inductioni

Induced in absence of iron. Maximally expressed during stationary phase when cultivated in low-iron minimal medium.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_1150.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiCOG1629.
HOGENOMiHOG000143472.
KOiK16087.
OMAiDPVWAPG.
OrthoDBiEOG6JQGXW.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug.
IPR000531. TonB-dep_rcpt_b-brl.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YJB2-1 [UniParc]FASTAAdd to Basket

« Hide

MKFTRTLVLV STSLLATVAT SQAQEVKRDT KKQGEVVLKP ITIISHGKDN    50
IEATGGTVLT YKDIEKLQPA NVSELFSRQS SIAVSGGGGP SKRIHVLGME 100
QSNLAVSVDG VPQTATSWHH TGSNVIDPAF LKRVEVEAGA AAADSGFGAA 150
AGAIRYETVN ALDLLEPGKT FGARIIGSYG TNGRGFSGST AAYGLKDGFD 200
WLLMLHGTSG HNYKNGDGTE ILGTEPAARN ILGKAGYEFD GNRIDIGYER 250
SRDKADRLIK MNMGLPGDTE YPLEVARDSV NIKYTRTDAT DMWDPEVQFY 300
YNRNDYWRND YQNRTNGNMI LKEDLYGGKL QNTFTIDYGK ITAGIDFGKH 350
DYNTDNYGHN DRRYRKFNTQ QVGAFTQGRF EFDNGFSLST GARYDYSRFA 400
DWNDEVFSDS GASVNGTLSY KFNEHIEVFA GASRTWLGYV LGDYGYVHAR 450
NNAFYTDPTF SPGRARNYKA GVNFGGADWS AGITLFDTRI AGLPNYDSQK 500
LGNDPEEYRS RGFTLNARYI WNYTTIGATF TKAKVTAGDD PVLPNSGSFM 550
PIGDMATLFI DQEIPDYNMK VGATLAWAGR ISDEAATAAN FYDQPAYTVV 600
NAYAEWNPPA VKNMTLRVGV ENLFNENYYE RTSFAPSQNR GGIDAVWAPG 650
RTFTFQTAFK F 661
Length:661
Mass (Da):72,931
Last modified:December 20, 2005 - v1
Checksum:i4EF2DE0C6CE74C7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ13316.1.
RefSeqiYP_419272.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ13316; CAJ13316; BAB2_1150.
GeneIDi3828017.
KEGGibmf:BAB2_1150.
PATRICi17849895. VBIBruMel86222_3455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ13316.1 .
RefSeqi YP_419272.1. NC_007624.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_1150.

Protein family/group databases

TCDBi 1.B.14.2.10. the outer membrane receptor (omr) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ13316 ; CAJ13316 ; BAB2_1150 .
GeneIDi 3828017.
KEGGi bmf:BAB2_1150.
PATRICi 17849895. VBIBruMel86222_3455.

Phylogenomic databases

eggNOGi COG1629.
HOGENOMi HOG000143472.
KOi K16087.
OMAi DPVWAPG.
OrthoDBi EOG6JQGXW.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-3412-MONOMER.
BMEL359391:GJOQ-3412-MONOMER.

Family and domain databases

Gene3Di 2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProi IPR012910. Plug.
IPR000531. TonB-dep_rcpt_b-brl.
[Graphical view ]
Pfami PF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. "Brucella abortus requires the heme transporter BhuA for maintenance of chronic infection in BALB/c mice."
    Paulley J.T., Anderson E.S., Roop R.M. II
    Infect. Immun. 75:5248-5254(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HEME TRANSPORT, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiBHUA_BRUA2
AccessioniPrimary (citable) accession number: Q2YJB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi