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Protein

Type IV secretion system putative outer membrane lipoprotein BAB2_0057

Gene

BAB2_0057

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. This protein is essential for pathogenesis in mice but is not required for intracellular survival.1 Publication

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2300-MONOMER.
BMEL359391:GJOQ-2300-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system putative outer membrane lipoprotein BAB2_0057
Gene namesi
Ordered Locus Names:BAB2_0057
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome II

Subcellular locationi

  1. Cell outer membrane Curated; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515PROSITE-ProRule annotationAdd
BLAST
Chaini16 – 172157Type IV secretion system putative outer membrane lipoprotein BAB2_0057PRO_0000291445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi16 – 161N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi16 – 161S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0057.

Structurei

3D structure databases

ProteinModelPortaliQ2YJ83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 172115OmpA-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2885.
HOGENOMiHOG000289240.
OMAiNSQMAVE.
OrthoDBiEOG6PP9QB.

Family and domain databases

Gene3Di3.30.1330.60. 1 hit.
InterProiIPR006665. OmpA/MotB_C.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
[Graphical view]
SUPFAMiSSF103088. SSF103088. 1 hit.
PROSITEiPS51123. OMPA_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YJ83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLVMVACA VSLAACSSPP KPPTVSGRHR IPINSPAAQE ELRLQVFPQE
60 70 80 90 100
PTAQATMWPA RPPKQTVNVY FPQDVTVFRP TSAQINQLHT LLWPVPKHIN
110 120 130 140 150
VRGLTDNNCP PPGDTQVARV RALAIYNWLI NQGVPASRIT ISYAPVKDYA
160 170
SNAPLSPGRV LNRRVDIEIL RK
Length:172
Mass (Da):19,028
Last modified:February 7, 2006 - v1
Checksum:iBEE06DB62310185E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73905.1.
AM040265 Genomic DNA. Translation: CAJ12223.1.
RefSeqiYP_418302.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12223; CAJ12223; BAB2_0057.
KEGGibmf:BAB2_0057.
PATRICi17847599. VBIBruMel86222_2333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73905.1.
AM040265 Genomic DNA. Translation: CAJ12223.1.
RefSeqiYP_418302.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YJ83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12223; CAJ12223; BAB2_0057.
KEGGibmf:BAB2_0057.
PATRICi17847599. VBIBruMel86222_2333.

Phylogenomic databases

eggNOGiCOG2885.
HOGENOMiHOG000289240.
OMAiNSQMAVE.
OrthoDBiEOG6PP9QB.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2300-MONOMER.
BMEL359391:GJOQ-2300-MONOMER.

Family and domain databases

Gene3Di3.30.1330.60. 1 hit.
InterProiIPR006665. OmpA/MotB_C.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
[Graphical view]
SUPFAMiSSF103088. SSF103088. 1 hit.
PROSITEiPS51123. OMPA_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
    Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
    J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiYP57_BRUA2
AccessioniPrimary (citable) accession number: Q2YJ83
Secondary accession number(s): Q57A25, Q9KIS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: April 1, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription is turned on at the beginning of the stationary phase of vegetative growth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.