Q2YJ83 (YP57_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type IV secretion system putative outer membrane lipoprotein BAB2_0057

Gene names

Ordered Locus Names:

BAB2_0057

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

General annotation (Comments)

Function	The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. This protein is essential for pathogenesis in mice but is not required for intracellular survival. Ref.1
Subcellular location	Cell outer membrane; Lipid-anchor Potential.
Miscellaneous	Transcription is turned on at the beginning of the stationary phase of vegetative growth.
Sequence similarities	Contains 1 OmpA-like domain.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
PTM	Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 172	157	Type IV secretion system putative outer membrane lipoprotein BAB2_0057		PRO_0000291445
Regions
	Domain	58 – 172	115	OmpA-like
Amino acid modifications
	Lipidation	16	1	N-palmitoyl cysteine Potential
	Lipidation	16	1	S-diacylglycerol cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YJ83 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: BEE06DB62310185E	FASTA	172	19,028
	10 20 30 40 50 60 MRTLVMVACA VSLAACSSPP KPPTVSGRHR IPINSPAAQE ELRLQVFPQE PTAQATMWPA 70 80 90 100 110 120 RPPKQTVNVY FPQDVTVFRP TSAQINQLHT LLWPVPKHIN VRGLTDNNCP PPGDTQVARV 130 140 150 160 170 RALAIYNWLI NQGVPASRIT ISYAPVKDYA SNAPLSPGRV LNRRVDIEIL RK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication." Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A. J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF226278 Genomic DNA. Translation: AAF73905.1. AM040265 Genomic DNA. Translation: CAJ12223.1.
RefSeq	YP_418302.1. NC_007624.1.
3D structure databases
ProteinModelPortal	Q2YJ83.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0057.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12223; CAJ12223; BAB2_0057.
GeneID	3827894.
KEGG	bmf:BAB2_0057.
PATRIC	17847599. VBIBruMel86222_2333.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2885.
HOGENOM	HOG000289240.
OMA	MAVELQV.
ProtClustDB	CLSK884257.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-2300-MONOMER.
Family and domain databases
Gene3D	3.30.1330.60. 1 hit.
InterPro	IPR006665. OmpA/MotB_C. [Graphical view]
Pfam	PF00691. OmpA. 1 hit. [Graphical view]
SUPFAM	SSF103088. OmpA/MotB_C. 1 hit.
PROSITE	PS01068. OMPA_1. False negative. PS51123. OMPA_2. 1 hit. PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YP57_BRUA2

Accession

Primary (citable) accession number: Q2YJ83
Secondary accession number(s): Q57A25, Q9KIS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program