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Protein

Type IV secretion system protein VirB11

Gene

virB11

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb11 is essential for pathogenesis in mice but is not required for intracellular survival.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi182 – 1898ATPSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2301-MONOMER.
BMEL359391:GJOQ-2301-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein VirB11
Gene namesi
Name:virB11
Ordered Locus Names:BAB2_0058
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Type IV secretion system protein VirB11PRO_0000291436Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0058.

Structurei

3D structure databases

ProteinModelPortaliQ2YJ82.
SMRiQ2YJ82. Positions 12-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP E family.Curated

Phylogenomic databases

eggNOGiCOG0630.
HOGENOMiHOG000119934.
KOiK03196.
OMAiRGAETYD.
OrthoDBiEOG6X3W2S.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YJ82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF
60 70 80 90 100
CERASAWEYY AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE
110 120 130 140 150
RIQIVRPPAC EHGTISVTIR KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP
160 170 180 190 200
FEQELLALKE AGDYMSFLRR AVQLERVIVV AGETGSGKTT LMKALMQEIP
210 220 230 240 250
FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT AATLLRSCLR
260 270 280 290 300
MKPTRILLAE LRGGETYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV
310 320 330 340 350
LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK
360
RALSLQHSEK TQ
Length:362
Mass (Da):40,885
Last modified:February 7, 2006 - v1
Checksum:i4C32B060F4FC79BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73904.1.
AM040265 Genomic DNA. Translation: CAJ12224.1.
RefSeqiWP_002969013.1. NC_007624.1.
YP_418303.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12224; CAJ12224; BAB2_0058.
KEGGibmf:BAB2_0058.
PATRICi17847601. VBIBruMel86222_2334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73904.1.
AM040265 Genomic DNA. Translation: CAJ12224.1.
RefSeqiWP_002969013.1. NC_007624.1.
YP_418303.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YJ82.
SMRiQ2YJ82. Positions 12-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12224; CAJ12224; BAB2_0058.
KEGGibmf:BAB2_0058.
PATRICi17847601. VBIBruMel86222_2334.

Phylogenomic databases

eggNOGiCOG0630.
HOGENOMiHOG000119934.
KOiK03196.
OMAiRGAETYD.
OrthoDBiEOG6X3W2S.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2301-MONOMER.
BMEL359391:GJOQ-2301-MONOMER.

Miscellaneous databases

PROiQ2YJ82.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
    Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
    J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiVIRBB_BRUA2
AccessioniPrimary (citable) accession number: Q2YJ82
Secondary accession number(s): Q57A24, Q9KIS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: April 29, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription is turned on at the beginning of the stationary phase of vegetative growth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.