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Q2YJ82

- VIRBB_BRUA2

UniProt

Q2YJ82 - VIRBB_BRUA2

Protein

Type IV secretion system protein VirB11

Gene

virB11

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb11 is essential for pathogenesis in mice but is not required for intracellular survival.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi182 – 1898ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. transport Source: InterPro

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2301-MONOMER.
    BMEL359391:GJOQ-2301-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type IV secretion system protein VirB11
    Gene namesi
    Name:virB11
    Ordered Locus Names:BAB2_0058
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Type IV secretion system protein VirB11PRO_0000291436Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB2_0058.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YJ82.
    SMRiQ2YJ82. Positions 12-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GSP E family.Curated

    Phylogenomic databases

    eggNOGiCOG0630.
    HOGENOMiHOG000119934.
    KOiK03196.
    OMAiRGAETYD.
    OrthoDBiEOG6X3W2S.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR001482. T2SS_protein-E.
    IPR014155. VirB11.
    [Graphical view]
    PfamiPF00437. T2SE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR02788. VirB11. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YJ82-1 [UniParc]FASTAAdd to Basket

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    MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF    50
    CERASAWEYY AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE 100
    RIQIVRPPAC EHGTISVTIR KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP 150
    FEQELLALKE AGDYMSFLRR AVQLERVIVV AGETGSGKTT LMKALMQEIP 200
    FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT AATLLRSCLR 250
    MKPTRILLAE LRGGETYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV 300
    LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK 350
    RALSLQHSEK TQ 362
    Length:362
    Mass (Da):40,885
    Last modified:February 7, 2006 - v1
    Checksum:i4C32B060F4FC79BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226278 Genomic DNA. Translation: AAF73904.1.
    AM040265 Genomic DNA. Translation: CAJ12224.1.
    RefSeqiYP_418303.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12224; CAJ12224; BAB2_0058.
    GeneIDi3827895.
    KEGGibmf:BAB2_0058.
    PATRICi17847601. VBIBruMel86222_2334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226278 Genomic DNA. Translation: AAF73904.1 .
    AM040265 Genomic DNA. Translation: CAJ12224.1 .
    RefSeqi YP_418303.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YJ82.
    SMRi Q2YJ82. Positions 12-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12224 ; CAJ12224 ; BAB2_0058 .
    GeneIDi 3827895.
    KEGGi bmf:BAB2_0058.
    PATRICi 17847601. VBIBruMel86222_2334.

    Phylogenomic databases

    eggNOGi COG0630.
    HOGENOMi HOG000119934.
    KOi K03196.
    OMAi RGAETYD.
    OrthoDBi EOG6X3W2S.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2301-MONOMER.
    BMEL359391:GJOQ-2301-MONOMER.

    Miscellaneous databases

    PROi Q2YJ82.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR001482. T2SS_protein-E.
    IPR014155. VirB11.
    [Graphical view ]
    Pfami PF00437. T2SE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR02788. VirB11. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
      Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
      J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiVIRBB_BRUA2
    AccessioniPrimary (citable) accession number: Q2YJ82
    Secondary accession number(s): Q57A24, Q9KIS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Transcription is turned on at the beginning of the stationary phase of vegetative growth.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3