Q2YJ82 (VIRBB_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type IV secretion system protein VirB11

Gene names

Name:	virB11
Ordered Locus Names:	BAB2_0058

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb11 is essential for pathogenesis in mice but is not required for intracellular survival. Ref.1
Subcellular location	Cytoplasm Potential.
Miscellaneous	Transcription is turned on at the beginning of the stationary phase of vegetative growth.
Sequence similarities	Belongs to the GSP E family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Type IV secretion system protein VirB11		PRO_0000291436
Regions
	Nucleotide binding	182 – 189	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YJ82 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 4C32B060F4FC79BD	FASTA	362	40,885
	10 20 30 40 50 60 MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF CERASAWEYY 70 80 90 100 110 120 AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE RIQIVRPPAC EHGTISVTIR 130 140 150 160 170 180 KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP FEQELLALKE AGDYMSFLRR AVQLERVIVV 190 200 210 220 230 240 AGETGSGKTT LMKALMQEIP FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT 250 260 270 280 290 300 AATLLRSCLR MKPTRILLAE LRGGETYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV 310 320 330 340 350 360 LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK RALSLQHSEK TQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication." Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A. J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF226278 Genomic DNA. Translation: AAF73904.1. AM040265 Genomic DNA. Translation: CAJ12224.1.
RefSeq	YP_418303.1. NC_007624.1.
3D structure databases
ProteinModelPortal	Q2YJ82.
SMR	Q2YJ82. Positions 12-356.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0058.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12224; CAJ12224; BAB2_0058.
GeneID	3827895.
KEGG	bmf:BAB2_0058.
PATRIC	17847601. VBIBruMel86222_2334.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0630.
HOGENOM	HOG000119934.
KO	K03196.
OMA	ICYNGDK.
ProtClustDB	CLSK861887.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-2301-MONOMER.
Family and domain databases
InterPro	IPR025662. Sigma_54_int_dom_ATP-bd_1. IPR001482. T2SS_protein-E. IPR014155. VirB11. [Graphical view]
Pfam	PF00437. T2SE. 1 hit. [Graphical view]
TIGRFAMs	TIGR02788. VirB11. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VIRBB_BRUA2

Accession

Primary (citable) accession number: Q2YJ82
Secondary accession number(s): Q57A24, Q9KIS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program