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Q2YJ82 (VIRBB_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type IV secretion system protein VirB11
Gene names
Name:virB11
Ordered Locus Names:BAB2_0058
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb11 is essential for pathogenesis in mice but is not required for intracellular survival. Ref.1

Subcellular location

Cytoplasm Potential.

Miscellaneous

Transcription is turned on at the beginning of the stationary phase of vegetative growth.

Sequence similarities

Belongs to the GSP E family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Type IV secretion system protein VirB11
PRO_0000291436

Regions

Nucleotide binding182 – 1898ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YJ82 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 4C32B060F4FC79BD

FASTA36240,885
        10         20         30         40         50         60 
MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF CERASAWEYY 

        70         80         90        100        110        120 
AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE RIQIVRPPAC EHGTISVTIR 

       130        140        150        160        170        180 
KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP FEQELLALKE AGDYMSFLRR AVQLERVIVV 

       190        200        210        220        230        240 
AGETGSGKTT LMKALMQEIP FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT 

       250        260        270        280        290        300 
AATLLRSCLR MKPTRILLAE LRGGETYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV 

       310        320        330        340        350        360 
LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK RALSLQHSEK 


TQ 

« Hide

References

« Hide 'large scale' references
[1]"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
[2]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF226278 Genomic DNA. Translation: AAF73904.1.
AM040265 Genomic DNA. Translation: CAJ12224.1.
RefSeqYP_418303.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YJ82.
SMRQ2YJ82. Positions 12-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12224; CAJ12224; BAB2_0058.
GeneID3827895.
KEGGbmf:BAB2_0058.
PATRIC17847601. VBIBruMel86222_2334.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0630.
HOGENOMHOG000119934.
KOK03196.
OMARGAETYD.
OrthoDBEOG6X3W2S.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2301-MONOMER.
BMEL359391:GJOQ-2301-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamPF00437. T2SE. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR02788. VirB11. 1 hit.
ProtoNetSearch...

Other

PROQ2YJ82.

Entry information

Entry nameVIRBB_BRUA2
AccessionPrimary (citable) accession number: Q2YJ82
Secondary accession number(s): Q57A24, Q9KIS5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names