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Q2YJ75

- VIRB5_BRUA2

UniProt

Q2YJ75 - VIRB5_BRUA2

Protein

Type IV secretion system protein virB5

Gene

virB5

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.1 Publication

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2307-MONOMER.
    BMEL359391:GJOQ-2307-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type IV secretion system protein virB5
    Gene namesi
    Name:virB5
    Ordered Locus Names:BAB2_0064
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 238218Type IV secretion system protein virB5PRO_0000290176Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB2_0064.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YJ75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the virb5 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG08232.
    HOGENOMiHOG000119375.
    KOiK03200.
    OMAiGIDQRIC.
    OrthoDBiEOG6W71ZN.

    Family and domain databases

    Gene3Di1.20.58.430. 1 hit.
    InterProiIPR014158. T4SS_VirB5.
    IPR023220. T4SS_VirB5-domain.
    [Graphical view]
    PfamiPF07996. T4SS. 1 hit.
    [Graphical view]
    SUPFAMiSSF101082. SSF101082. 1 hit.
    TIGRFAMsiTIGR02791. VirB5. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2YJ75-1 [UniParc]FASTAAdd to Basket

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    MKKIILSFAF ALTVTSTAHA QLPVTDAGSI AQNLANHLEQ MVKFAQQIEQ    50
    LKQQFEQQKM QFDALTGNRG LGDILRDPTL RSYLPHNWRD LYEAVMSGGY 100
    LAAAGETANL LRKSQVYDPC ASISDKDQRI ACEAKVVKPV QDKVMTSKAY 150
    DATDKRLQEI ESLMQEINKT GDPKAIAELQ GRIESENAMI QNEDTRLRLY 200
    QQMAEAQDKL LDERQHELDA KDNARRGYPQ PKALEAAY 238
    Length:238
    Mass (Da):26,829
    Last modified:February 7, 2006 - v1
    Checksum:iE10B3F9F3E75E02E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226278 Genomic DNA. Translation: AAF73898.1.
    AM040265 Genomic DNA. Translation: CAJ12230.1.
    RefSeqiWP_006077544.1. NC_007624.1.
    YP_418309.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12230; CAJ12230; BAB2_0064.
    GeneIDi3827978.
    KEGGibmf:BAB2_0064.
    PATRICi17847613. VBIBruMel86222_2340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226278 Genomic DNA. Translation: AAF73898.1 .
    AM040265 Genomic DNA. Translation: CAJ12230.1 .
    RefSeqi WP_006077544.1. NC_007624.1.
    YP_418309.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YJ75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12230 ; CAJ12230 ; BAB2_0064 .
    GeneIDi 3827978.
    KEGGi bmf:BAB2_0064.
    PATRICi 17847613. VBIBruMel86222_2340.

    Phylogenomic databases

    eggNOGi NOG08232.
    HOGENOMi HOG000119375.
    KOi K03200.
    OMAi GIDQRIC.
    OrthoDBi EOG6W71ZN.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2307-MONOMER.
    BMEL359391:GJOQ-2307-MONOMER.

    Miscellaneous databases

    PROi Q2YJ75.

    Family and domain databases

    Gene3Di 1.20.58.430. 1 hit.
    InterProi IPR014158. T4SS_VirB5.
    IPR023220. T4SS_VirB5-domain.
    [Graphical view ]
    Pfami PF07996. T4SS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101082. SSF101082. 1 hit.
    TIGRFAMsi TIGR02791. VirB5. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
      Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
      J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiVIRB5_BRUA2
    AccessioniPrimary (citable) accession number: Q2YJ75
    Secondary accession number(s): Q9KIS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Transcription is turned on at the beginning of the stationary phase of vegetative growth.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3