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Protein

Type IV secretion system protein virB5

Gene

virB5

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.1 Publication

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2307-MONOMER.
BMEL359391:GJOQ-2307-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein virB5
Gene namesi
Name:virB5
Ordered Locus Names:BAB2_0064
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 238218Type IV secretion system protein virB5PRO_0000290176Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0064.

Structurei

3D structure databases

ProteinModelPortaliQ2YJ75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the virb5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG08232.
HOGENOMiHOG000119375.
KOiK03200.
OMAiAMIQNEQ.
OrthoDBiEOG6W71ZN.

Family and domain databases

Gene3Di1.20.58.430. 1 hit.
InterProiIPR014158. T4SS_VirB5.
IPR023220. T4SS_VirB5-domain.
[Graphical view]
PfamiPF07996. T4SS. 1 hit.
[Graphical view]
SUPFAMiSSF101082. SSF101082. 1 hit.
TIGRFAMsiTIGR02791. VirB5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YJ75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIILSFAF ALTVTSTAHA QLPVTDAGSI AQNLANHLEQ MVKFAQQIEQ
60 70 80 90 100
LKQQFEQQKM QFDALTGNRG LGDILRDPTL RSYLPHNWRD LYEAVMSGGY
110 120 130 140 150
LAAAGETANL LRKSQVYDPC ASISDKDQRI ACEAKVVKPV QDKVMTSKAY
160 170 180 190 200
DATDKRLQEI ESLMQEINKT GDPKAIAELQ GRIESENAMI QNEDTRLRLY
210 220 230
QQMAEAQDKL LDERQHELDA KDNARRGYPQ PKALEAAY
Length:238
Mass (Da):26,829
Last modified:February 7, 2006 - v1
Checksum:iE10B3F9F3E75E02E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73898.1.
AM040265 Genomic DNA. Translation: CAJ12230.1.
RefSeqiWP_006077544.1. NZ_KN046823.1.
YP_418309.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12230; CAJ12230; BAB2_0064.
GeneIDi3827978.
KEGGibmf:BAB2_0064.
PATRICi17847613. VBIBruMel86222_2340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73898.1.
AM040265 Genomic DNA. Translation: CAJ12230.1.
RefSeqiWP_006077544.1. NZ_KN046823.1.
YP_418309.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YJ75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12230; CAJ12230; BAB2_0064.
GeneIDi3827978.
KEGGibmf:BAB2_0064.
PATRICi17847613. VBIBruMel86222_2340.

Phylogenomic databases

eggNOGiNOG08232.
HOGENOMiHOG000119375.
KOiK03200.
OMAiAMIQNEQ.
OrthoDBiEOG6W71ZN.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2307-MONOMER.
BMEL359391:GJOQ-2307-MONOMER.

Miscellaneous databases

PROiQ2YJ75.

Family and domain databases

Gene3Di1.20.58.430. 1 hit.
InterProiIPR014158. T4SS_VirB5.
IPR023220. T4SS_VirB5-domain.
[Graphical view]
PfamiPF07996. T4SS. 1 hit.
[Graphical view]
SUPFAMiSSF101082. SSF101082. 1 hit.
TIGRFAMsiTIGR02791. VirB5. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
    Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
    J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiVIRB5_BRUA2
AccessioniPrimary (citable) accession number: Q2YJ75
Secondary accession number(s): Q9KIS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: January 7, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription is turned on at the beginning of the stationary phase of vegetative growth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.