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Q2YJ75 (VIRB5_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type IV secretion system protein virB5
Gene names
Name:virB5
Ordered Locus Names:BAB2_0064
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Ref.1

Miscellaneous

Transcription is turned on at the beginning of the stationary phase of vegetative growth.

Sequence similarities

Belongs to the virb5 family.

Ontologies

Keywords
   Biological processVirulence
   DomainSignal
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 238218Type IV secretion system protein virB5
PRO_0000290176

Sequences

Sequence LengthMass (Da)Tools
Q2YJ75 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: E10B3F9F3E75E02E

FASTA23826,829
        10         20         30         40         50         60 
MKKIILSFAF ALTVTSTAHA QLPVTDAGSI AQNLANHLEQ MVKFAQQIEQ LKQQFEQQKM 

        70         80         90        100        110        120 
QFDALTGNRG LGDILRDPTL RSYLPHNWRD LYEAVMSGGY LAAAGETANL LRKSQVYDPC 

       130        140        150        160        170        180 
ASISDKDQRI ACEAKVVKPV QDKVMTSKAY DATDKRLQEI ESLMQEINKT GDPKAIAELQ 

       190        200        210        220        230 
GRIESENAMI QNEDTRLRLY QQMAEAQDKL LDERQHELDA KDNARRGYPQ PKALEAAY 

« Hide

References

« Hide 'large scale' references
[1]"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
[2]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF226278 Genomic DNA. Translation: AAF73898.1.
AM040265 Genomic DNA. Translation: CAJ12230.1.
RefSeqYP_418309.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YJ75.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12230; CAJ12230; BAB2_0064.
GeneID3827978.
KEGGbmf:BAB2_0064.
PATRIC17847613. VBIBruMel86222_2340.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG08232.
HOGENOMHOG000119375.
KOK03200.
OMAFALDAYD.
OrthoDBEOG6W71ZN.
ProtClustDBCLSK884267.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2307-MONOMER.
BMEL359391:GJOQ-2307-MONOMER.

Family and domain databases

Gene3D1.20.58.430. 1 hit.
InterProIPR014158. T4SS_VirB5.
IPR023220. T4SS_VirB5-domain.
[Graphical view]
PfamPF07996. T4SS. 1 hit.
[Graphical view]
SUPFAMSSF101082. SSF101082. 1 hit.
TIGRFAMsTIGR02791. VirB5. 1 hit.
ProtoNetSearch...

Other

PROQ2YJ75.

Entry information

Entry nameVIRB5_BRUA2
AccessionPrimary (citable) accession number: Q2YJ75
Secondary accession number(s): Q9KIS8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: March 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names