Q2YJ50 (VJBR_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type quorum sensing-dependent transcriptional regulator VjbR

Gene names

Name:	vjbR
Ordered Locus Names:	BAB2_0118

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transcriptional regulator mediating the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) By similarity.
Miscellaneous	A B.abortus vjbR deletion mutant complemented with the defective B.melitensis D82A mutant does not display the typical clumping phenotype observed in B.melitensis.
Sequence similarities	Contains 1 HTH luxR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Quorum sensing Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	HTH-type quorum sensing-dependent transcriptional regulator VjbR		PRO_0000319926
Regions
	Domain	183 – 248	66	HTH luxR-type
	DNA binding	207 – 226	20	H-T-H motif By similarity
	Region	76 – 179	104	C12-HSL binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YJ50 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 2D845BA0737094CC	FASTA	259	28,625
	10 20 30 40 50 60 MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD CTKVNSADLT 70 80 90 100 110 120 VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA RDLKEDADIC PAVAELLHDA 130 140 150 160 170 180 EKHGLGNLFI AVSARNPKGV AGCTVFTFEV EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC 190 200 210 220 230 240 KDANSVASLL TPREVDCLRW AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA 250 VATALSLGII DMPEVQHLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.
[2]	"Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis." Uzureau S., Godefroid M., Deschamps C., Lemaire J., De Bolle X., Letesson J.-J. J. Bacteriol. 189:6035-6047(2007) [PubMed] [Europe PMC] [Abstract] Cited for: ABSENCE OF CLUMPING PHENOTYPE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040265 Genomic DNA. Translation: CAJ12284.1.
RefSeq	YP_418357.1. NC_007624.1.
3D structure databases
ProteinModelPortal	Q2YJ50.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0118.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12284; CAJ12284; BAB2_0118.
GeneID	3828180.
KEGG	bmf:BAB2_0118.
PATRIC	17847723. VBIBruMel86222_2395.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2771.
HOGENOM	HOG000000633.
OMA	NYFTIDP.
ProtClustDB	CLSK899077.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-2361-MONOMER.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 3.30.450.80. 1 hit.
InterPro	IPR016032. Sig_transdc_resp-reg_C-effctor. IPR005143. TF_LuxR_autoind-bd_dom. IPR000792. Tscrpt_reg_LuxR_C. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF03472. Autoind_bind. 1 hit. PF00196. GerE. 1 hit. [Graphical view]
PRINTS	PR00038. HTHLUXR.
SMART	SM00421. HTH_LUXR. 1 hit. [Graphical view]
SUPFAM	SSF46894. Bipartite_resp_reg_C-effector. 1 hit. SSF75516. TF_LuxR_autoind-bd_dom. 1 hit.
PROSITE	PS00622. HTH_LUXR_1. False negative. PS50043. HTH_LUXR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VJBR_BRUA2

Accession

Primary (citable) accession number: Q2YJ50

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program