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Protein

HTH-type quorum sensing-dependent transcriptional regulator VjbR

Gene

vjbR

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator involved in the global control of Brucella gene expression (PubMed:28334833). Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes (By similarity). Binds with high specificity to a large number of sites distributed across the genome. The VjbR-binding motif contains an asymmetric 16-bp consensus sequence, an unusual feature among LuxR-type regulators (PubMed:28334833). May directly modulate expression of many genes, including virulence determinants, components of the respiratory chain, efflux systems, elements predicted to participate in ion transport and adaptation to stress, uncharacterized proteins, as well as transcriptional regulators probably responsible for the observed indirect VjbR-mediated effects (PubMed:28334833).By similarity1 Publication

Miscellaneous

A B.abortus vjbR deletion mutant complemented with the defective B.melitensis D82A mutant does not display the typical clumping phenotype observed in B.melitensis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi207 – 226H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processQuorum sensing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type quorum sensing-dependent transcriptional regulator VjbRCurated
Gene namesi
Name:vjbR
Ordered Locus Names:BAB2_0118
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199261 – 259HTH-type quorum sensing-dependent transcriptional regulator VjbRAdd BLAST259

Expressioni

Inductioni

Regulated at the post-transcriptional level. In rich medium, protein is expressed only in the stationary phase of growth. In minimal medium, protein is expressed only at pH 5.5 in the presence of urocanic acid.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ2YJ50
SMRiQ2YJ50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 248HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 179C12-HSL bindingSequence analysisAdd BLAST104

Phylogenomic databases

HOGENOMiHOG000000633
KOiK21697
OMAiNQEAGMM

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.450.80, 1 hit
InterProiView protein in InterPro
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR005143 TF_LuxR_autoind-bd_dom
IPR036693 TF_LuxR_autoind-bd_dom_sf
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF03472 Autoind_bind, 1 hit
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF75516 SSF75516, 1 hit
PROSITEiView protein in PROSITE
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YJ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD
60 70 80 90 100
CTKVNSADLT VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA
110 120 130 140 150
RDLKEDADIC PAVAELLHDA EKHGLGNLFI AVSARNPKGV AGCTVFTFEV
160 170 180 190 200
EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC KDANSVASLL TPREVDCLRW
210 220 230 240 250
AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA VATALSLGII

DMPEVQHLV
Length:259
Mass (Da):28,625
Last modified:February 7, 2006 - v1
Checksum:i2D845BA0737094CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA Translation: CAJ12284.1
RefSeqiWP_002966460.1, NZ_KN046823.1

Genome annotation databases

EnsemblBacteriaiCAJ12284; CAJ12284; BAB2_0118
GeneIDi29595784
KEGGibmf:BAB2_0118
PATRICifig|359391.11.peg.2065

Entry informationi

Entry nameiVJBR_BRUA2
AccessioniPrimary (citable) accession number: Q2YJ50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 7, 2006
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names

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