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Q2YJ50

- VJBR_BRUA2

UniProt

Q2YJ50 - VJBR_BRUA2

Protein

HTH-type quorum sensing-dependent transcriptional regulator VjbR

Gene

vjbR

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Transcriptional regulator mediating the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone).By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi207 – 22620H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. quorum sensing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Quorum sensing, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2361-MONOMER.
    BMEL359391:GJOQ-2361-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type quorum sensing-dependent transcriptional regulator VjbR
    Gene namesi
    Name:vjbR
    Ordered Locus Names:BAB2_0118
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259HTH-type quorum sensing-dependent transcriptional regulator VjbRPRO_0000319926Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB2_0118.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YJ50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini183 – 24866HTH luxR-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 179104C12-HSL bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2771.
    HOGENOMiHOG000000633.
    OMAiQEDANEC.
    OrthoDBiEOG6PS5W1.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.450.80. 1 hit.
    InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR005143. TF_LuxR_autoind-bd_dom.
    IPR000792. Tscrpt_reg_LuxR_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF03472. Autoind_bind. 1 hit.
    PF00196. GerE. 1 hit.
    [Graphical view]
    PRINTSiPR00038. HTHLUXR.
    SMARTiSM00421. HTH_LUXR. 1 hit.
    [Graphical view]
    SUPFAMiSSF46894. SSF46894. 1 hit.
    SSF75516. SSF75516. 1 hit.
    PROSITEiPS50043. HTH_LUXR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YJ50-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD    50
    CTKVNSADLT VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA 100
    RDLKEDADIC PAVAELLHDA EKHGLGNLFI AVSARNPKGV AGCTVFTFEV 150
    EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC KDANSVASLL TPREVDCLRW 200
    AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA VATALSLGII 250
    DMPEVQHLV 259
    Length:259
    Mass (Da):28,625
    Last modified:February 7, 2006 - v1
    Checksum:i2D845BA0737094CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12284.1.
    RefSeqiYP_418357.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12284; CAJ12284; BAB2_0118.
    GeneIDi3828180.
    KEGGibmf:BAB2_0118.
    PATRICi17847723. VBIBruMel86222_2395.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12284.1 .
    RefSeqi YP_418357.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YJ50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12284 ; CAJ12284 ; BAB2_0118 .
    GeneIDi 3828180.
    KEGGi bmf:BAB2_0118.
    PATRICi 17847723. VBIBruMel86222_2395.

    Phylogenomic databases

    eggNOGi COG2771.
    HOGENOMi HOG000000633.
    OMAi QEDANEC.
    OrthoDBi EOG6PS5W1.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2361-MONOMER.
    BMEL359391:GJOQ-2361-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.450.80. 1 hit.
    InterProi IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR005143. TF_LuxR_autoind-bd_dom.
    IPR000792. Tscrpt_reg_LuxR_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF03472. Autoind_bind. 1 hit.
    PF00196. GerE. 1 hit.
    [Graphical view ]
    PRINTSi PR00038. HTHLUXR.
    SMARTi SM00421. HTH_LUXR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46894. SSF46894. 1 hit.
    SSF75516. SSF75516. 1 hit.
    PROSITEi PS50043. HTH_LUXR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.
    2. "Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis."
      Uzureau S., Godefroid M., Deschamps C., Lemaire J., De Bolle X., Letesson J.-J.
      J. Bacteriol. 189:6035-6047(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF CLUMPING PHENOTYPE.

    Entry informationi

    Entry nameiVJBR_BRUA2
    AccessioniPrimary (citable) accession number: Q2YJ50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    A B.abortus vjbR deletion mutant complemented with the defective B.melitensis D82A mutant does not display the typical clumping phenotype observed in B.melitensis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3