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Q2YJ50

- VJBR_BRUA2

UniProt

Q2YJ50 - VJBR_BRUA2

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Protein

HTH-type quorum sensing-dependent transcriptional regulator VjbR

Gene
vjbR, BAB2_0118
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Transcriptional regulator mediating the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 22620H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. quorum sensing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Quorum sensing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2361-MONOMER.
BMEL359391:GJOQ-2361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Gene namesi
Name:vjbR
Ordered Locus Names:BAB2_0118
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259HTH-type quorum sensing-dependent transcriptional regulator VjbRPRO_0000319926Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0118.

Structurei

3D structure databases

ProteinModelPortaliQ2YJ50.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 24866HTH luxR-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 179104C12-HSL binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2771.
HOGENOMiHOG000000633.
OMAiQEDANEC.
OrthoDBiEOG6PS5W1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YJ50-1 [UniParc]FASTAAdd to Basket

« Hide

MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD    50
CTKVNSADLT VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA 100
RDLKEDADIC PAVAELLHDA EKHGLGNLFI AVSARNPKGV AGCTVFTFEV 150
EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC KDANSVASLL TPREVDCLRW 200
AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA VATALSLGII 250
DMPEVQHLV 259
Length:259
Mass (Da):28,625
Last modified:February 7, 2006 - v1
Checksum:i2D845BA0737094CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12284.1.
RefSeqiYP_418357.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12284; CAJ12284; BAB2_0118.
GeneIDi3828180.
KEGGibmf:BAB2_0118.
PATRICi17847723. VBIBruMel86222_2395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12284.1 .
RefSeqi YP_418357.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YJ50.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12284 ; CAJ12284 ; BAB2_0118 .
GeneIDi 3828180.
KEGGi bmf:BAB2_0118.
PATRICi 17847723. VBIBruMel86222_2395.

Phylogenomic databases

eggNOGi COG2771.
HOGENOMi HOG000000633.
OMAi QEDANEC.
OrthoDBi EOG6PS5W1.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2361-MONOMER.
BMEL359391:GJOQ-2361-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProi IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view ]
PRINTSi PR00038. HTHLUXR.
SMARTi SM00421. HTH_LUXR. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEi PS50043. HTH_LUXR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. "Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis."
    Uzureau S., Godefroid M., Deschamps C., Lemaire J., De Bolle X., Letesson J.-J.
    J. Bacteriol. 189:6035-6047(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF CLUMPING PHENOTYPE.

Entry informationi

Entry nameiVJBR_BRUA2
AccessioniPrimary (citable) accession number: Q2YJ50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

A B.abortus vjbR deletion mutant complemented with the defective B.melitensis D82A mutant does not display the typical clumping phenotype observed in B.melitensis.

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi