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Q2YJ50 (VJBR_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Gene names
Name:vjbR
Ordered Locus Names:BAB2_0118
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transcriptional regulator mediating the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) By similarity.

Miscellaneous

A B.abortus vjbR deletion mutant complemented with the defective B.melitensis D82A mutant does not display the typical clumping phenotype observed in B.melitensis.

Sequence similarities

Contains 1 HTH luxR-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259HTH-type quorum sensing-dependent transcriptional regulator VjbR
PRO_0000319926

Regions

Domain183 – 24866HTH luxR-type
DNA binding207 – 22620H-T-H motif By similarity
Region76 – 179104C12-HSL binding Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YJ50 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 2D845BA0737094CC

FASTA25928,625
        10         20         30         40         50         60 
MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD CTKVNSADLT 

        70         80         90        100        110        120 
VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA RDLKEDADIC PAVAELLHDA 

       130        140        150        160        170        180 
EKHGLGNLFI AVSARNPKGV AGCTVFTFEV EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC 

       190        200        210        220        230        240 
KDANSVASLL TPREVDCLRW AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA 

       250 
VATALSLGII DMPEVQHLV 

« Hide

References

« Hide 'large scale' references
[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.
[2]"Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis."
Uzureau S., Godefroid M., Deschamps C., Lemaire J., De Bolle X., Letesson J.-J.
J. Bacteriol. 189:6035-6047(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ABSENCE OF CLUMPING PHENOTYPE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040265 Genomic DNA. Translation: CAJ12284.1.
RefSeqYP_418357.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YJ50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0118.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12284; CAJ12284; BAB2_0118.
GeneID3828180.
KEGGbmf:BAB2_0118.
PATRIC17847723. VBIBruMel86222_2395.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2771.
HOGENOMHOG000000633.
OMAQEDANEC.
OrthoDBEOG6PS5W1.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2361-MONOMER.
BMEL359391:GJOQ-2361-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSPR00038. HTHLUXR.
SMARTSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVJBR_BRUA2
AccessionPrimary (citable) accession number: Q2YJ50
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names