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Protein

HTH-type quorum sensing-dependent transcriptional regulator VjbR

Gene

vjbR

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcriptional regulator mediating the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone).By similarity

Miscellaneous

A B.abortus vjbR deletion mutant complemented with the defective B.melitensis D82A mutant does not display the typical clumping phenotype observed in B.melitensis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi207 – 226H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processQuorum sensing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Gene namesi
Name:vjbR
Ordered Locus Names:BAB2_0118
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199261 – 259HTH-type quorum sensing-dependent transcriptional regulator VjbRAdd BLAST259

Structurei

3D structure databases

ProteinModelPortaliQ2YJ50.
SMRiQ2YJ50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 248HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 179C12-HSL bindingSequence analysisAdd BLAST104

Phylogenomic databases

HOGENOMiHOG000000633.
OMAiSHYERID.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiView protein in InterPro
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
PRINTSiPR00038. HTHLUXR.
SMARTiView protein in SMART
SM00421. HTH_LUXR. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiView protein in PROSITE
PS50043. HTH_LUXR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YJ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD
60 70 80 90 100
CTKVNSADLT VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA
110 120 130 140 150
RDLKEDADIC PAVAELLHDA EKHGLGNLFI AVSARNPKGV AGCTVFTFEV
160 170 180 190 200
EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC KDANSVASLL TPREVDCLRW
210 220 230 240 250
AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA VATALSLGII

DMPEVQHLV
Length:259
Mass (Da):28,625
Last modified:February 7, 2006 - v1
Checksum:i2D845BA0737094CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12284.1.
RefSeqiWP_002966460.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ12284; CAJ12284; BAB2_0118.
GeneIDi3828180.
KEGGibmf:BAB2_0118.
PATRICi17847723. VBIBruMel86222_2395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12284.1.
RefSeqiWP_002966460.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YJ50.
SMRiQ2YJ50.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12284; CAJ12284; BAB2_0118.
GeneIDi3828180.
KEGGibmf:BAB2_0118.
PATRICi17847723. VBIBruMel86222_2395.

Phylogenomic databases

HOGENOMiHOG000000633.
OMAiSHYERID.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiView protein in InterPro
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
PRINTSiPR00038. HTHLUXR.
SMARTiView protein in SMART
SM00421. HTH_LUXR. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiView protein in PROSITE
PS50043. HTH_LUXR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVJBR_BRUA2
AccessioniPrimary (citable) accession number: Q2YJ50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 7, 2006
Last modified: February 15, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.