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Protein

HTH-type quorum sensing-dependent transcriptional regulator VjbR

Gene

vjbR

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcriptional regulator mediating the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 22620H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. quorum sensing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Quorum sensing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2361-MONOMER.
BMEL359391:GJOQ-2361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type quorum sensing-dependent transcriptional regulator VjbR
Gene namesi
Name:vjbR
Ordered Locus Names:BAB2_0118
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259HTH-type quorum sensing-dependent transcriptional regulator VjbRPRO_0000319926Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0118.

Structurei

3D structure databases

ProteinModelPortaliQ2YJ50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 24866HTH luxR-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 179104C12-HSL bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2771.
HOGENOMiHOG000000633.
OMAiQEDANEC.
OrthoDBiEOG6PS5W1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YJ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD
60 70 80 90 100
CTKVNSADLT VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA
110 120 130 140 150
RDLKEDADIC PAVAELLHDA EKHGLGNLFI AVSARNPKGV AGCTVFTFEV
160 170 180 190 200
EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC KDANSVASLL TPREVDCLRW
210 220 230 240 250
AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA VATALSLGII

DMPEVQHLV
Length:259
Mass (Da):28,625
Last modified:February 7, 2006 - v1
Checksum:i2D845BA0737094CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12284.1.
RefSeqiYP_418357.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12284; CAJ12284; BAB2_0118.
KEGGibmf:BAB2_0118.
PATRICi17847723. VBIBruMel86222_2395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12284.1.
RefSeqiYP_418357.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YJ50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12284; CAJ12284; BAB2_0118.
KEGGibmf:BAB2_0118.
PATRICi17847723. VBIBruMel86222_2395.

Phylogenomic databases

eggNOGiCOG2771.
HOGENOMiHOG000000633.
OMAiQEDANEC.
OrthoDBiEOG6PS5W1.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2361-MONOMER.
BMEL359391:GJOQ-2361-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. "Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis."
    Uzureau S., Godefroid M., Deschamps C., Lemaire J., De Bolle X., Letesson J.-J.
    J. Bacteriol. 189:6035-6047(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF CLUMPING PHENOTYPE.

Entry informationi

Entry nameiVJBR_BRUA2
AccessioniPrimary (citable) accession number: Q2YJ50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 7, 2006
Last modified: April 1, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

A B.abortus vjbR deletion mutant complemented with the defective B.melitensis D82A mutant does not display the typical clumping phenotype observed in B.melitensis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.