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Q2YIT8 (VIRB4_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type IV secretion system protein virB4
Gene names
Name:virB4
Ordered Locus Names:BAB2_0065
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Ref.1

Miscellaneous

Transcription is turned on at the beginning of the stationary phase of vegetative growth.

Sequence similarities

Belongs to the TrbE/VirB4 family.

Ontologies

Keywords
   Biological processVirulence
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 831831Type IV secretion system protein virB4
PRO_0000290168

Regions

Nucleotide binding457 – 4648ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YIT8 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 657AAA319B4CC8E5

FASTA83194,572
        10         20         30         40         50         60 
MGAQSKYAQQ LNNERSLAPF IPFRSQVGPT TVITRDGDFV RTWRIAGLAF ETQDKEKLLI 

        70         80         90        100        110        120 
RKDQLNTLFR AIASNNVALW SHNVRRRTWD HLKSFFSNPF CDALDKKYYG SFSGYRMMSN 

       130        140        150        160        170        180 
ELYLTVIYRP VPAKISRLFN VAVHRSHAEI LQEQQLAIRK LDEIGNQIET SLRRYGGDDG 

       190        200        210        220        230        240 
RGIEVLSTYE DKHGALCSQQ LEFYNFLLSG EWQKVRVPSC PLDEYLGTGW VYAGTETIEI 

       250        260        270        280        290        300 
RTANATRYAR GIDFKDYANH TEPGILNGLM YSDYEYVITQ SFSFMTKRDG KEFLTRQKQR 

       310        320        330        340        350        360 
LQNTEDGSAS QIMEMDIAID QLGRGDFVMG EYHYSLLVFA EDMETVRHNT SHAMNILQDN 

       370        380        390        400        410        420 
GFLATVIATA TDAAFYAQLP CNWRYRPRVA GLTSLNFAGL SCFHNFRAGK RDGNPWGQAL 

       430        440        450        460        470        480 
TLLKTPSGQP AYLNFHYSKG DEDNFDKKLL GNTRIIGQSG AGKTVLMNFC LAQAQKYLHN 

       490        500        510        520        530        540 
APMGMCNVFF DKDQGAKGTI LAIGGKYLAI RNGEPTGFNP FQMEPTAGNI LFLEKLVQVL 

       550        560        570        580        590        600 
VSRDGQHVTT TDESRISHAI RTVMRMRPEL RRLSTVLQNV TEGSDRQDRE NSVAKRLAKW 

       610        620        630        640        650        660 
CFDDGTGKRG TFWWVLDCPQ DQIDFNTHSN YGFDGTDFLD NADVRTPISM YLLHRMELAI 

       670        680        690        700        710        720 
DGRRFIYWMD EAWKWVDDEA FSEFANNKQL TIRKQNGLGV FATQMPSSLL NSKVASALVQ 

       730        740        750        760        770        780 
QVATEIYLPN PKADYHEYTD GFKVTNEEFD IIRSMSEESR MFLVKQGHHS MICRLELNGF 

       790        800        810        820        830 
DDELAILSGS SDNNELLDQV IAEVGDDPSV WLPVFQERRK ARIASSKSTG R 

« Hide

References

« Hide 'large scale' references
[1]"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
[2]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF226278 Genomic DNA. Translation: AAF73897.1.
AM040265 Genomic DNA. Translation: CAJ12231.1.
RefSeqYP_418310.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YIT8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12231; CAJ12231; BAB2_0065.
GeneID3827979.
KEGGbmf:BAB2_0065.
PATRIC17847615. VBIBruMel86222_2341.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3451.
HOGENOMHOG000119263.
KOK03199.
OMAFKDYASH.
OrthoDBEOG6HMX9P.
ProtClustDBCLSK884268.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2308-MONOMER.
BMEL359391:GJOQ-2308-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR004346. CagE_TrbE_VirB.
IPR018145. CagE_TrbE_VirB_cntrl_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF03135. CagE_TrbE_VirB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00929. VirB4_CagE. 1 hit.
ProtoNetSearch...

Other

PROQ2YIT8.

Entry information

Entry nameVIRB4_BRUA2
AccessionPrimary (citable) accession number: Q2YIT8
Secondary accession number(s): Q57A17, Q9KIS9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names