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Q2YIT8

- VIRB4_BRUA2

UniProt

Q2YIT8 - VIRB4_BRUA2

Protein

Type IV secretion system protein virB4

Gene

virB4

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi457 – 4648ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2308-MONOMER.
    BMEL359391:GJOQ-2308-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type IV secretion system protein virB4
    Gene namesi
    Name:virB4
    Ordered Locus Names:BAB2_0065
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 831831Type IV secretion system protein virB4PRO_0000290168Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB2_0065.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YIT8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrbE/VirB4 family.Curated

    Phylogenomic databases

    eggNOGiCOG3451.
    HOGENOMiHOG000119263.
    KOiK03199.
    OMAiRYFRIRT.
    OrthoDBiEOG6HMX9P.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR004346. CagE_TrbE_VirB.
    IPR018145. CagE_TrbE_VirB_cntrl_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF03135. CagE_TrbE_VirB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00929. VirB4_CagE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YIT8-1 [UniParc]FASTAAdd to Basket

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    MGAQSKYAQQ LNNERSLAPF IPFRSQVGPT TVITRDGDFV RTWRIAGLAF    50
    ETQDKEKLLI RKDQLNTLFR AIASNNVALW SHNVRRRTWD HLKSFFSNPF 100
    CDALDKKYYG SFSGYRMMSN ELYLTVIYRP VPAKISRLFN VAVHRSHAEI 150
    LQEQQLAIRK LDEIGNQIET SLRRYGGDDG RGIEVLSTYE DKHGALCSQQ 200
    LEFYNFLLSG EWQKVRVPSC PLDEYLGTGW VYAGTETIEI RTANATRYAR 250
    GIDFKDYANH TEPGILNGLM YSDYEYVITQ SFSFMTKRDG KEFLTRQKQR 300
    LQNTEDGSAS QIMEMDIAID QLGRGDFVMG EYHYSLLVFA EDMETVRHNT 350
    SHAMNILQDN GFLATVIATA TDAAFYAQLP CNWRYRPRVA GLTSLNFAGL 400
    SCFHNFRAGK RDGNPWGQAL TLLKTPSGQP AYLNFHYSKG DEDNFDKKLL 450
    GNTRIIGQSG AGKTVLMNFC LAQAQKYLHN APMGMCNVFF DKDQGAKGTI 500
    LAIGGKYLAI RNGEPTGFNP FQMEPTAGNI LFLEKLVQVL VSRDGQHVTT 550
    TDESRISHAI RTVMRMRPEL RRLSTVLQNV TEGSDRQDRE NSVAKRLAKW 600
    CFDDGTGKRG TFWWVLDCPQ DQIDFNTHSN YGFDGTDFLD NADVRTPISM 650
    YLLHRMELAI DGRRFIYWMD EAWKWVDDEA FSEFANNKQL TIRKQNGLGV 700
    FATQMPSSLL NSKVASALVQ QVATEIYLPN PKADYHEYTD GFKVTNEEFD 750
    IIRSMSEESR MFLVKQGHHS MICRLELNGF DDELAILSGS SDNNELLDQV 800
    IAEVGDDPSV WLPVFQERRK ARIASSKSTG R 831
    Length:831
    Mass (Da):94,572
    Last modified:February 7, 2006 - v1
    Checksum:i657AAA319B4CC8E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226278 Genomic DNA. Translation: AAF73897.1.
    AM040265 Genomic DNA. Translation: CAJ12231.1.
    RefSeqiYP_418310.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12231; CAJ12231; BAB2_0065.
    GeneIDi3827979.
    KEGGibmf:BAB2_0065.
    PATRICi17847615. VBIBruMel86222_2341.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226278 Genomic DNA. Translation: AAF73897.1 .
    AM040265 Genomic DNA. Translation: CAJ12231.1 .
    RefSeqi YP_418310.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YIT8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12231 ; CAJ12231 ; BAB2_0065 .
    GeneIDi 3827979.
    KEGGi bmf:BAB2_0065.
    PATRICi 17847615. VBIBruMel86222_2341.

    Phylogenomic databases

    eggNOGi COG3451.
    HOGENOMi HOG000119263.
    KOi K03199.
    OMAi RYFRIRT.
    OrthoDBi EOG6HMX9P.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2308-MONOMER.
    BMEL359391:GJOQ-2308-MONOMER.

    Miscellaneous databases

    PROi Q2YIT8.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR004346. CagE_TrbE_VirB.
    IPR018145. CagE_TrbE_VirB_cntrl_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF03135. CagE_TrbE_VirB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00929. VirB4_CagE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
      Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
      J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiVIRB4_BRUA2
    AccessioniPrimary (citable) accession number: Q2YIT8
    Secondary accession number(s): Q57A17, Q9KIS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Transcription is turned on at the beginning of the stationary phase of vegetative growth.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3