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Q2YIT8

- VIRB4_BRUA2

UniProt

Q2YIT8 - VIRB4_BRUA2

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Protein

Type IV secretion system protein virB4

Gene

virB4

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi457 – 4648ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2308-MONOMER.
BMEL359391:GJOQ-2308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein virB4
Gene namesi
Name:virB4
Ordered Locus Names:BAB2_0065
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Type IV secretion system protein virB4PRO_0000290168Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0065.

Structurei

3D structure databases

ProteinModelPortaliQ2YIT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrbE/VirB4 family.Curated

Phylogenomic databases

eggNOGiCOG3451.
HOGENOMiHOG000119263.
KOiK03199.
OMAiRYFRIRT.
OrthoDBiEOG6HMX9P.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR004346. CagE_TrbE_VirB.
IPR018145. CagE_TrbE_VirB_cntrl_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03135. CagE_TrbE_VirB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00929. VirB4_CagE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YIT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAQSKYAQQ LNNERSLAPF IPFRSQVGPT TVITRDGDFV RTWRIAGLAF
60 70 80 90 100
ETQDKEKLLI RKDQLNTLFR AIASNNVALW SHNVRRRTWD HLKSFFSNPF
110 120 130 140 150
CDALDKKYYG SFSGYRMMSN ELYLTVIYRP VPAKISRLFN VAVHRSHAEI
160 170 180 190 200
LQEQQLAIRK LDEIGNQIET SLRRYGGDDG RGIEVLSTYE DKHGALCSQQ
210 220 230 240 250
LEFYNFLLSG EWQKVRVPSC PLDEYLGTGW VYAGTETIEI RTANATRYAR
260 270 280 290 300
GIDFKDYANH TEPGILNGLM YSDYEYVITQ SFSFMTKRDG KEFLTRQKQR
310 320 330 340 350
LQNTEDGSAS QIMEMDIAID QLGRGDFVMG EYHYSLLVFA EDMETVRHNT
360 370 380 390 400
SHAMNILQDN GFLATVIATA TDAAFYAQLP CNWRYRPRVA GLTSLNFAGL
410 420 430 440 450
SCFHNFRAGK RDGNPWGQAL TLLKTPSGQP AYLNFHYSKG DEDNFDKKLL
460 470 480 490 500
GNTRIIGQSG AGKTVLMNFC LAQAQKYLHN APMGMCNVFF DKDQGAKGTI
510 520 530 540 550
LAIGGKYLAI RNGEPTGFNP FQMEPTAGNI LFLEKLVQVL VSRDGQHVTT
560 570 580 590 600
TDESRISHAI RTVMRMRPEL RRLSTVLQNV TEGSDRQDRE NSVAKRLAKW
610 620 630 640 650
CFDDGTGKRG TFWWVLDCPQ DQIDFNTHSN YGFDGTDFLD NADVRTPISM
660 670 680 690 700
YLLHRMELAI DGRRFIYWMD EAWKWVDDEA FSEFANNKQL TIRKQNGLGV
710 720 730 740 750
FATQMPSSLL NSKVASALVQ QVATEIYLPN PKADYHEYTD GFKVTNEEFD
760 770 780 790 800
IIRSMSEESR MFLVKQGHHS MICRLELNGF DDELAILSGS SDNNELLDQV
810 820 830
IAEVGDDPSV WLPVFQERRK ARIASSKSTG R
Length:831
Mass (Da):94,572
Last modified:February 7, 2006 - v1
Checksum:i657AAA319B4CC8E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73897.1.
AM040265 Genomic DNA. Translation: CAJ12231.1.
RefSeqiYP_418310.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12231; CAJ12231; BAB2_0065.
GeneIDi3827979.
KEGGibmf:BAB2_0065.
PATRICi17847615. VBIBruMel86222_2341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226278 Genomic DNA. Translation: AAF73897.1 .
AM040265 Genomic DNA. Translation: CAJ12231.1 .
RefSeqi YP_418310.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YIT8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0065.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12231 ; CAJ12231 ; BAB2_0065 .
GeneIDi 3827979.
KEGGi bmf:BAB2_0065.
PATRICi 17847615. VBIBruMel86222_2341.

Phylogenomic databases

eggNOGi COG3451.
HOGENOMi HOG000119263.
KOi K03199.
OMAi RYFRIRT.
OrthoDBi EOG6HMX9P.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2308-MONOMER.
BMEL359391:GJOQ-2308-MONOMER.

Miscellaneous databases

PROi Q2YIT8.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR004346. CagE_TrbE_VirB.
IPR018145. CagE_TrbE_VirB_cntrl_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF03135. CagE_TrbE_VirB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00929. VirB4_CagE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication."
    Sieira R., Comerci D.J., Sanchez D.O., Ugalde R.A.
    J. Bacteriol. 182:4849-4855(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTION, FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiVIRB4_BRUA2
AccessioniPrimary (citable) accession number: Q2YIT8
Secondary accession number(s): Q57A17, Q9KIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription is turned on at the beginning of the stationary phase of vegetative growth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3