Q2YIQ6 (TPIS2_BRUA2) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 43.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Triosephosphate isomerase 2 Short name=TIM 2 EC=5.3.1.1 Alternative name(s): Triose-phosphate isomerase 2 | ||||||
| Gene names |
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| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 359391 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 256 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147_B |
| Pathway | Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147_B Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147_B |
| Subunit structure | Homodimer By similarity. HAMAP MF_00147_B |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00147_B. |
| Sequence similarities | Belongs to the triosephosphate isomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Gluconeogenesis Glycolysis Pentose shunt |
| Cellular component | Cytoplasm |
| Molecular function | Isomerase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysisInferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shuntInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 256 | 256 | Triosephosphate isomerase 2 HAMAP MF_00147_B | PRO_0000090190 | |||||
Sites | |||||||||
| Active site | 96 | 1 | Electrophile By similarity | ||||||
| Active site | 169 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 11 | 1 | Substrate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus." Sangari F.J., Aguero J., Garcia-Lobo J.M. Microbiology 146:487-495(2000) [PubMed: 10708387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U57100 Genomic DNA. Translation: AAD11524.1. AM040265 Genomic DNA. Translation: CAJ12533.1. |
| RefSeq | YP_418574.1. NC_007624.1. |
3D structure databases | |
| ProteinModelPortal | Q2YIQ6. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YIQ6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3827783. |
| GenomeReviews | Gene locus BAB2_0367 in contig AM040265_GR. |
| KEGG | bmf:BAB2_0367. |
| PATRIC | 17848260. VBIBruMel86222_2660. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0149. |
| HOGENOM | HBG708281. |
| OMA | WAIGEKG. |
| ProtClustDB | PRK00042. |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB2_0367-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00147_B. TIM_B. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| KO | K01803. |
| PANTHER | PTHR21139. Triophos_ismrse. 1 hit. |
| Pfam | PF00121. TIM. 1 hit. [Graphical view] |
| SUPFAM | SSF51351. Triophos_ismrse. 1 hit. |
| PROSITE | PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TPIS2_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YIQ6 Secondary accession number(s): Q578Z0, Q9ZB27 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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