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Q2YIQ6 (TPIS2_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triosephosphate isomerase 2

Short name=TIM 2
EC=5.3.1.1
Alternative name(s):
Triose-phosphate isomerase 2
Gene names
Name:tpiA2
Synonyms:tpiA, tpiA-2
Ordered Locus Names:BAB2_0367
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00147

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00147.

Sequence similarities

Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
Pentose shunt
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontriose-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Triosephosphate isomerase 2 HAMAP-Rule MF_00147
PRO_0000090190

Sites

Active site961Electrophile By similarity
Active site1691Proton acceptor By similarity
Binding site111Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YIQ6 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 809780A0B12568A6

FASTA25627,871
        10         20         30         40         50         60 
MTKFWIGTSW KMNKTLAEAR LFAEALKAAD AGRSPDIQRF VIPPFTAVRE VKEILSGTSV 

        70         80         90        100        110        120 
KVGAQNMHWA DQGAWTGEIS PLMLKDCNLD IVELGHSERR EHFGETNETV GLKVEAAVRH 

       130        140        150        160        170        180 
GLIPLICIGE TLEDRESGRA AAVLEEEVRG ALSKLSEAQK QAEILFAYEP VWAIGENGIP 

       190        200        210        220        230        240 
ASADYADARQ AEIIAVAQSV LARRVPCLYG GSVNPGNCEE LIACPHIDGL FIGRSAWNVE 

       250 
GYLDILARCA TKVQAN 

« Hide

References

« Hide 'large scale' references
[1]"The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus."
Sangari F.J., Aguero J., Garcia-Lobo J.M.
Microbiology 146:487-495(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U57100 Genomic DNA. Translation: AAD11524.1.
AM040265 Genomic DNA. Translation: CAJ12533.1.
RefSeqYP_418574.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YIQ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0367.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12533; CAJ12533; BAB2_0367.
GeneID3827783.
KEGGbmf:BAB2_0367.
PATRIC17848260. VBIBruMel86222_2660.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0149.
HOGENOMHOG000226412.
KOK01803.
OMAFAHEIDG.
OrthoDBEOG66QM23.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2611-MONOMER.
BMEL359391:GJOQ-2611-MONOMER.
UniPathwayUPA00109; UER00189.
UPA00138.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00147_B. TIM_B.
InterProIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERPTHR21139. PTHR21139. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMSSF51351. SSF51351. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPIS2_BRUA2
AccessionPrimary (citable) accession number: Q2YIQ6
Secondary accession number(s): Q578Z0, Q9ZB27
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names