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Q2YIQ6

- TPIS2_BRUA2

UniProt

Q2YIQ6 - TPIS2_BRUA2

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Protein

Triosephosphate isomerase 2

Gene

tpiA2

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Active sitei96 – 961ElectrophileUniRule annotation
Active sitei169 – 1691Proton acceptorUniRule annotation

GO - Molecular functioni

  1. triose-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
  3. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2611-MONOMER.
BMEL359391:GJOQ-2611-MONOMER.
UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase 2UniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIM 2UniRule annotation
Alternative name(s):
Triose-phosphate isomerase 2UniRule annotation
Gene namesi
Name:tpiA2UniRule annotation
Synonyms:tpiA, tpiA-2
Ordered Locus Names:BAB2_0367
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Triosephosphate isomerase 2PRO_0000090190Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB2_0367.

Structurei

3D structure databases

ProteinModelPortaliQ2YIQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0149.
HOGENOMiHOG000226412.
KOiK01803.
OMAiFAHEIDG.
OrthoDBiEOG66QM23.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YIQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKFWIGTSW KMNKTLAEAR LFAEALKAAD AGRSPDIQRF VIPPFTAVRE
60 70 80 90 100
VKEILSGTSV KVGAQNMHWA DQGAWTGEIS PLMLKDCNLD IVELGHSERR
110 120 130 140 150
EHFGETNETV GLKVEAAVRH GLIPLICIGE TLEDRESGRA AAVLEEEVRG
160 170 180 190 200
ALSKLSEAQK QAEILFAYEP VWAIGENGIP ASADYADARQ AEIIAVAQSV
210 220 230 240 250
LARRVPCLYG GSVNPGNCEE LIACPHIDGL FIGRSAWNVE GYLDILARCA

TKVQAN
Length:256
Mass (Da):27,871
Last modified:December 20, 2005 - v1
Checksum:i809780A0B12568A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57100 Genomic DNA. Translation: AAD11524.1.
AM040265 Genomic DNA. Translation: CAJ12533.1.
RefSeqiYP_418574.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12533; CAJ12533; BAB2_0367.
GeneIDi3827783.
KEGGibmf:BAB2_0367.
PATRICi17848260. VBIBruMel86222_2660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57100 Genomic DNA. Translation: AAD11524.1 .
AM040265 Genomic DNA. Translation: CAJ12533.1 .
RefSeqi YP_418574.1. NC_007624.1.

3D structure databases

ProteinModelPortali Q2YIQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0367.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12533 ; CAJ12533 ; BAB2_0367 .
GeneIDi 3827783.
KEGGi bmf:BAB2_0367.
PATRICi 17848260. VBIBruMel86222_2660.

Phylogenomic databases

eggNOGi COG0149.
HOGENOMi HOG000226412.
KOi K01803.
OMAi FAHEIDG.
OrthoDBi EOG66QM23.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00189 .
UPA00138 .
BioCyci BABO359391:GKDV-2611-MONOMER.
BMEL359391:GJOQ-2611-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00147_B. TIM_B.
InterProi IPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view ]
PANTHERi PTHR21139. PTHR21139. 1 hit.
Pfami PF00121. TIM. 1 hit.
[Graphical view ]
SUPFAMi SSF51351. SSF51351. 1 hit.
PROSITEi PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus."
    Sangari F.J., Aguero J., Garcia-Lobo J.M.
    Microbiology 146:487-495(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiTPIS2_BRUA2
AccessioniPrimary (citable) accession number: Q2YIQ6
Secondary accession number(s): Q578Z0, Q9ZB27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3