Q2YIQ6 (TPIS2_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase 2
Short name=TIM 2
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase 2

Gene names

Name:	tpiA2
Synonyms:	tpiA, tpiA-2
Ordered Locus Names:	BAB2_0367

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Triosephosphate isomerase 2 HAMAP-Rule MF_00147		PRO_0000090190
Sites
	Active site	96	1	Electrophile By similarity
	Active site	169	1	Proton acceptor By similarity
	Binding site	11	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YIQ6 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 809780A0B12568A6	FASTA	256	27,871
	10 20 30 40 50 60 MTKFWIGTSW KMNKTLAEAR LFAEALKAAD AGRSPDIQRF VIPPFTAVRE VKEILSGTSV 70 80 90 100 110 120 KVGAQNMHWA DQGAWTGEIS PLMLKDCNLD IVELGHSERR EHFGETNETV GLKVEAAVRH 130 140 150 160 170 180 GLIPLICIGE TLEDRESGRA AAVLEEEVRG ALSKLSEAQK QAEILFAYEP VWAIGENGIP 190 200 210 220 230 240 ASADYADARQ AEIIAVAQSV LARRVPCLYG GSVNPGNCEE LIACPHIDGL FIGRSAWNVE 250 GYLDILARCA TKVQAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus." Sangari F.J., Aguero J., Garcia-Lobo J.M. Microbiology 146:487-495(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57100 Genomic DNA. Translation: AAD11524.1. AM040265 Genomic DNA. Translation: CAJ12533.1.
RefSeq	YP_418574.1. NC_007624.1.
3D structure databases
ProteinModelPortal	Q2YIQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0367.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12533; CAJ12533; BAB2_0367.
GeneID	3827783.
KEGG	bmf:BAB2_0367.
PATRIC	17848260. VBIBruMel86222_2660.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HOG000226412.
KO	K01803.
OMA	LTGAQNM.
ProtClustDB	PRK00042.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-2611-MONOMER.
UniPathway	UPA00109; UER00189. UPA00138.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00147_B. TIM_B.
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
PANTHER	PTHR21139. PTHR21139. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS2_BRUA2

Accession

Primary (citable) accession number: Q2YIQ6
Secondary accession number(s): Q578Z0, Q9ZB27

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program