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Protein

L-erythrulose-1-phosphate isomerase

Gene

eryH

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the isomerization of D-erythrulose-4P to L-erythrulose-1P. Involved in the degradation pathway of erythritol, that allows B.abortus to grow on this compound as the sole carbon source.1 Publication

Catalytic activityi

L-erythrulose 1-phosphate = D-erythrulose 4-phosphate.1 Publication

Pathwayi: erythritol degradation

This protein is involved in the pathway erythritol degradation, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway erythritol degradation and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96ElectrophileBy similarity1
Active sitei169Proton acceptorBy similarity1
Binding sitei175Substrate; via amide nitrogenBy similarity1
Binding sitei212SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-19887.
UniPathwayiUPA01066.

Names & Taxonomyi

Protein namesi
Recommended name:
L-erythrulose-1-phosphate isomerase1 Publication (EC:5.3.1.331 Publication)
Alternative name(s):
D-3-tetrulose-4-phosphate isomerase1 Publication
Gene namesi
Name:eryH1 Publication
Synonyms:tpiA-2Imported
Ordered Locus Names:BAB2_0367
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene do not grow on erythritol as sole carbon source, in contrast to wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901901 – 256L-erythrulose-1-phosphate isomeraseAdd BLAST256

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2YIQ6.
SMRiQ2YIQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

HOGENOMiHOG000226412.
KOiK01803.
OMAiFAHEIDG.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiView protein in Pfam
PF00121. TIM. 1 hit.
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiView protein in PROSITE
PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YIQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKFWIGTSW KMNKTLAEAR LFAEALKAAD AGRSPDIQRF VIPPFTAVRE
60 70 80 90 100
VKEILSGTSV KVGAQNMHWA DQGAWTGEIS PLMLKDCNLD IVELGHSERR
110 120 130 140 150
EHFGETNETV GLKVEAAVRH GLIPLICIGE TLEDRESGRA AAVLEEEVRG
160 170 180 190 200
ALSKLSEAQK QAEILFAYEP VWAIGENGIP ASADYADARQ AEIIAVAQSV
210 220 230 240 250
LARRVPCLYG GSVNPGNCEE LIACPHIDGL FIGRSAWNVE GYLDILARCA

TKVQAN
Length:256
Mass (Da):27,871
Last modified:December 20, 2005 - v1
Checksum:i809780A0B12568A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57100 Genomic DNA. Translation: AAD11524.1.
AM040265 Genomic DNA. Translation: CAJ12533.1.
RefSeqiWP_002965777.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ12533; CAJ12533; BAB2_0367.
GeneIDi3827783.
KEGGibmf:BAB2_0367.
PATRICi17848260. VBIBruMel86222_2660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57100 Genomic DNA. Translation: AAD11524.1.
AM040265 Genomic DNA. Translation: CAJ12533.1.
RefSeqiWP_002965777.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YIQ6.
SMRiQ2YIQ6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12533; CAJ12533; BAB2_0367.
GeneIDi3827783.
KEGGibmf:BAB2_0367.
PATRICi17848260. VBIBruMel86222_2660.

Phylogenomic databases

HOGENOMiHOG000226412.
KOiK01803.
OMAiFAHEIDG.

Enzyme and pathway databases

UniPathwayiUPA01066.
BioCyciMetaCyc:MONOMER-19887.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiView protein in Pfam
PF00121. TIM. 1 hit.
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiView protein in PROSITE
PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiERYH_BRUA2
AccessioniPrimary (citable) accession number: Q2YIQ6
Secondary accession number(s): Q578Z0, Q9ZB27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: March 15, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.