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Protein

L-erythrulose-1-phosphate isomerase

Gene

eryH

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the isomerization of D-erythrulose-4P to L-erythrulose-1P. Involved in the degradation pathway of erythritol, that allows B.abortus to grow on this compound as the sole carbon source.1 Publication

Catalytic activityi

L-erythrulose 1-phosphate = D-erythrulose 4-phosphate.1 Publication

Pathwayi: erythritol degradation

This protein is involved in the pathway erythritol degradation, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway erythritol degradation and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96ElectrophileBy similarity1
Active sitei169Proton acceptorBy similarity1
Binding sitei175Substrate; via amide nitrogenBy similarity1
Binding sitei212SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-19887
UniPathwayiUPA01066

Names & Taxonomyi

Protein namesi
Recommended name:
L-erythrulose-1-phosphate isomerase1 Publication (EC:5.3.1.331 Publication)
Alternative name(s):
D-3-tetrulose-4-phosphate isomerase1 Publication
Gene namesi
Name:eryH1 Publication
Synonyms:tpiA-2Imported
Ordered Locus Names:BAB2_0367
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene do not grow on erythritol as sole carbon source, in contrast to wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901901 – 256L-erythrulose-1-phosphate isomeraseAdd BLAST256

Proteomic databases

PRIDEiQ2YIQ6

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ2YIQ6
SMRiQ2YIQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

HOGENOMiHOG000226412
KOiK21910
OMAiEPQWAIG

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YIQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKFWIGTSW KMNKTLAEAR LFAEALKAAD AGRSPDIQRF VIPPFTAVRE
60 70 80 90 100
VKEILSGTSV KVGAQNMHWA DQGAWTGEIS PLMLKDCNLD IVELGHSERR
110 120 130 140 150
EHFGETNETV GLKVEAAVRH GLIPLICIGE TLEDRESGRA AAVLEEEVRG
160 170 180 190 200
ALSKLSEAQK QAEILFAYEP VWAIGENGIP ASADYADARQ AEIIAVAQSV
210 220 230 240 250
LARRVPCLYG GSVNPGNCEE LIACPHIDGL FIGRSAWNVE GYLDILARCA

TKVQAN
Length:256
Mass (Da):27,871
Last modified:December 20, 2005 - v1
Checksum:i809780A0B12568A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57100 Genomic DNA Translation: AAD11524.1
AM040265 Genomic DNA Translation: CAJ12533.1
RefSeqiWP_002965777.1, NZ_KN046823.1

Genome annotation databases

EnsemblBacteriaiCAJ12533; CAJ12533; BAB2_0367
KEGGibmf:BAB2_0367
PATRICifig|359391.11.peg.2319

Similar proteinsi

Entry informationi

Entry nameiERYH_BRUA2
AccessioniPrimary (citable) accession number: Q2YIQ6
Secondary accession number(s): Q578Z0, Q9ZB27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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