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Q2YIQ6

- TPIS2_BRUA2

UniProt

Q2YIQ6 - TPIS2_BRUA2

Protein

Triosephosphate isomerase 2

Gene

tpiA2

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Active sitei96 – 961ElectrophileUniRule annotation
    Active sitei169 – 1691Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. triose-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP
    3. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis, Pentose shunt

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2611-MONOMER.
    BMEL359391:GJOQ-2611-MONOMER.
    UniPathwayiUPA00109; UER00189.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Triosephosphate isomerase 2UniRule annotation (EC:5.3.1.1UniRule annotation)
    Short name:
    TIM 2UniRule annotation
    Alternative name(s):
    Triose-phosphate isomerase 2UniRule annotation
    Gene namesi
    Name:tpiA2UniRule annotation
    Synonyms:tpiA, tpiA-2
    Ordered Locus Names:BAB2_0367
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Triosephosphate isomerase 2PRO_0000090190Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB2_0367.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YIQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the triosephosphate isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0149.
    HOGENOMiHOG000226412.
    KOiK01803.
    OMAiFAHEIDG.
    OrthoDBiEOG66QM23.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00147_B. TIM_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view]
    PANTHERiPTHR21139. PTHR21139. 1 hit.
    PfamiPF00121. TIM. 1 hit.
    [Graphical view]
    SUPFAMiSSF51351. SSF51351. 1 hit.
    PROSITEiPS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YIQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKFWIGTSW KMNKTLAEAR LFAEALKAAD AGRSPDIQRF VIPPFTAVRE    50
    VKEILSGTSV KVGAQNMHWA DQGAWTGEIS PLMLKDCNLD IVELGHSERR 100
    EHFGETNETV GLKVEAAVRH GLIPLICIGE TLEDRESGRA AAVLEEEVRG 150
    ALSKLSEAQK QAEILFAYEP VWAIGENGIP ASADYADARQ AEIIAVAQSV 200
    LARRVPCLYG GSVNPGNCEE LIACPHIDGL FIGRSAWNVE GYLDILARCA 250
    TKVQAN 256
    Length:256
    Mass (Da):27,871
    Last modified:December 20, 2005 - v1
    Checksum:i809780A0B12568A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57100 Genomic DNA. Translation: AAD11524.1.
    AM040265 Genomic DNA. Translation: CAJ12533.1.
    RefSeqiYP_418574.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12533; CAJ12533; BAB2_0367.
    GeneIDi3827783.
    KEGGibmf:BAB2_0367.
    PATRICi17848260. VBIBruMel86222_2660.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57100 Genomic DNA. Translation: AAD11524.1 .
    AM040265 Genomic DNA. Translation: CAJ12533.1 .
    RefSeqi YP_418574.1. NC_007624.1.

    3D structure databases

    ProteinModelPortali Q2YIQ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0367.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12533 ; CAJ12533 ; BAB2_0367 .
    GeneIDi 3827783.
    KEGGi bmf:BAB2_0367.
    PATRICi 17848260. VBIBruMel86222_2660.

    Phylogenomic databases

    eggNOGi COG0149.
    HOGENOMi HOG000226412.
    KOi K01803.
    OMAi FAHEIDG.
    OrthoDBi EOG66QM23.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00189 .
    UPA00138 .
    BioCyci BABO359391:GKDV-2611-MONOMER.
    BMEL359391:GJOQ-2611-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00147_B. TIM_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view ]
    PANTHERi PTHR21139. PTHR21139. 1 hit.
    Pfami PF00121. TIM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51351. SSF51351. 1 hit.
    PROSITEi PS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus."
      Sangari F.J., Aguero J., Garcia-Lobo J.M.
      Microbiology 146:487-495(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiTPIS2_BRUA2
    AccessioniPrimary (citable) accession number: Q2YIQ6
    Secondary accession number(s): Q578Z0, Q9ZB27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3