Q2YIN5 (MODC_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Molybdenum import ATP-binding protein ModC
EC=3.6.3.29

Gene names

Name:	modC
Ordered Locus Names:	BAB2_0089

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + molybdate(Out) = ADP + phosphate + molybdate(In).
Subunit structure	The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA) Potential.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Molybdenum Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW molybdate transmembrane-transporting ATPase activity Inferred from electronic annotation. Source: EC molybdenum ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Molybdenum import ATP-binding protein ModC		PRO_0000260200
Regions
	Domain	1 – 233	233	ABC transporter
	Nucleotide binding	32 – 39	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YIN5 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 06DF08E9A2C188F9	FASTA	359	38,881
	10 20 30 40 50 60 MSGLTVSIRG RNGAFAIEAG FAAEGGVTAL FGHSGAGKTT LLKMIAGTLR PENGRIAVGD 70 80 90 100 110 120 FTLFDAQKGI NLPPEKRRIG YVFQDARLFA YMSVKRNLTY ARWAGHRPAT RSFDEVVALL 130 140 150 160 170 180 GIGHLLDRRP STLSGGERQR VAIGRALLSD PALLLLDEPL SSLDHARRQE ILPFIERLRD 190 200 210 220 230 240 ESHVPIVYVS HEIDEVARLA DQIVLLSAGR VTASGAAADI FPLIDAESEG GGVLLEGIVS 250 260 270 280 290 300 AYDERYKLAE IDLGGASFQL SDAGLKQTMH VRLRVRARDV SIARKIPEAI SIRNLLPVTV 310 320 330 340 350 TGIERGEGPN AHVFLDFRGR RLGARLTRRS VDDLGLSVGD QVVALVKAVS VDRAAIREK

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040265 Genomic DNA. Translation: CAJ12255.1.
RefSeq	YP_418334.1. NC_007624.1.
3D structure databases
ProteinModelPortal	Q2YIN5.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0089.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12255; CAJ12255; BAB2_0089.
GeneID	3827997.
KEGG	bmf:BAB2_0089.
PATRIC	17847665. VBIBruMel86222_2366.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4148.
KO	K02017.
OMA	TRRSWDQ.
ProtClustDB	CLSK898641.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-2332-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015852. ABC_transpr_ModC. IPR008995. Mo/tungstate-bd_C_term_dom. IPR011868. ModC_ABC_ATP-bd. IPR005116. Transp-assoc_OB_typ1. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. PF03459. TOBE. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF50331. MOP_like. 1 hit.
TIGRFAMs	TIGR02142. modC_ABC. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51241. MODC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MODC_BRUA2

Accession

Primary (citable) accession number: Q2YIN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program