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Q2YIH8

- HISZ_BRUA2

UniProt

Q2YIH8 - HISZ_BRUA2

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Protein
ATP phosphoribosyltransferase regulatory subunit
Gene
hisZ, BAB2_0182
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine By similarity.UniRule annotation

Pathwayi

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2425-MONOMER.
BMEL359391:GJOQ-2425-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase regulatory subunit
Gene namesi
Name:hisZ
Ordered Locus Names:BAB2_0182
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378ATP phosphoribosyltransferase regulatory subunitUniRule annotation
PRO_0000242825Add
BLAST

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits By similarity.

Protein-protein interaction databases

STRINGi359391.BAB2_0182.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3705.
HOGENOMiHOG000141880.
KOiK02502.
OrthoDBiEOG6BPDH4.

Family and domain databases

HAMAPiMF_00125. HisZ.
InterProiIPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YIH8-1 [UniParc]FASTAAdd to Basket

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MTMVGSRTSP IFNALRVELN AREAELVEIP LIQPADPFLD MAGEDLRRRI    50
FLTENENGDS LCLRPEFTIP VCRNHIALNA ATPKRYAYLG EVFRQRRDGA 100
AEFLQAGIED LGAADEAASD ARSLADALSC VKAIAPDAPL EIVLGDQSVF 150
AGMLKALGLP QGWRKKLLRS FGDAHSMDLA LAELTGTQRR DPLPESLAVL 200
VAEGDEIGLA RMLEAEMLEA GISPGAGRTP VEIARRLIEK EDLAATHFPA 250
AALDLLRQFL AIRVSLDMAA VTLRAFAADN ALDLGAVLQK FEARADAIAQ 300
AGIEMKDIIY DASFGRPLDY YTGLVYEIRD ASNRQDGVLA GGGRYDRLLT 350
MLGACEAIPG VGFSIWLDRL QALAGEKQ 378
Length:378
Mass (Da):40,921
Last modified:June 27, 2006 - v2
Checksum:iE827A4A65543E4E2
GO

Sequence cautioni

The sequence CAJ12348.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12348.1. Different initiation.
RefSeqiYP_418411.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12348; CAJ12348; BAB2_0182.
GeneIDi3827674.
KEGGibmf:BAB2_0182.
PATRICi17847870. VBIBruMel86222_2468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12348.1 . Different initiation.
RefSeqi YP_418411.1. NC_007624.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0182.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12348 ; CAJ12348 ; BAB2_0182 .
GeneIDi 3827674.
KEGGi bmf:BAB2_0182.
PATRICi 17847870. VBIBruMel86222_2468.

Phylogenomic databases

eggNOGi COG3705.
HOGENOMi HOG000141880.
KOi K02502.
OrthoDBi EOG6BPDH4.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .
BioCyci BABO359391:GKDV-2425-MONOMER.
BMEL359391:GJOQ-2425-MONOMER.

Family and domain databases

HAMAPi MF_00125. HisZ.
InterProi IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiHISZ_BRUA2
AccessioniPrimary (citable) accession number: Q2YIH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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