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Q2YIH8

- HISZ_BRUA2

UniProt

Q2YIH8 - HISZ_BRUA2

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Protein

ATP phosphoribosyltransferase regulatory subunit

Gene

hisZ

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.UniRule annotation

Pathwayi

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2425-MONOMER.
BMEL359391:GJOQ-2425-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase regulatory subunitUniRule annotation
Gene namesi
Name:hisZUniRule annotation
Ordered Locus Names:BAB2_0182
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378ATP phosphoribosyltransferase regulatory subunitPRO_0000242825Add
BLAST

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB2_0182.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG3705.
HOGENOMiHOG000141880.
KOiK02502.
OrthoDBiEOG6BPDH4.

Family and domain databases

HAMAPiMF_00125. HisZ.
InterProiIPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YIH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMVGSRTSP IFNALRVELN AREAELVEIP LIQPADPFLD MAGEDLRRRI
60 70 80 90 100
FLTENENGDS LCLRPEFTIP VCRNHIALNA ATPKRYAYLG EVFRQRRDGA
110 120 130 140 150
AEFLQAGIED LGAADEAASD ARSLADALSC VKAIAPDAPL EIVLGDQSVF
160 170 180 190 200
AGMLKALGLP QGWRKKLLRS FGDAHSMDLA LAELTGTQRR DPLPESLAVL
210 220 230 240 250
VAEGDEIGLA RMLEAEMLEA GISPGAGRTP VEIARRLIEK EDLAATHFPA
260 270 280 290 300
AALDLLRQFL AIRVSLDMAA VTLRAFAADN ALDLGAVLQK FEARADAIAQ
310 320 330 340 350
AGIEMKDIIY DASFGRPLDY YTGLVYEIRD ASNRQDGVLA GGGRYDRLLT
360 370
MLGACEAIPG VGFSIWLDRL QALAGEKQ
Length:378
Mass (Da):40,921
Last modified:June 27, 2006 - v2
Checksum:iE827A4A65543E4E2
GO

Sequence cautioni

The sequence CAJ12348.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12348.1. Different initiation.
RefSeqiYP_418411.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12348; CAJ12348; BAB2_0182.
GeneIDi3827674.
KEGGibmf:BAB2_0182.
PATRICi17847870. VBIBruMel86222_2468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040265 Genomic DNA. Translation: CAJ12348.1 . Different initiation.
RefSeqi YP_418411.1. NC_007624.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB2_0182.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12348 ; CAJ12348 ; BAB2_0182 .
GeneIDi 3827674.
KEGGi bmf:BAB2_0182.
PATRICi 17847870. VBIBruMel86222_2468.

Phylogenomic databases

eggNOGi COG3705.
HOGENOMi HOG000141880.
KOi K02502.
OrthoDBi EOG6BPDH4.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .
BioCyci BABO359391:GKDV-2425-MONOMER.
BMEL359391:GJOQ-2425-MONOMER.

Family and domain databases

HAMAPi MF_00125. HisZ.
InterProi IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiHISZ_BRUA2
AccessioniPrimary (citable) accession number: Q2YIH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3