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Q2YIH8

- HISZ_BRUA2

UniProt

Q2YIH8 - HISZ_BRUA2

Protein

ATP phosphoribosyltransferase regulatory subunit

Gene

hisZ

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.UniRule annotation

    Pathwayi

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2425-MONOMER.
    BMEL359391:GJOQ-2425-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferase regulatory subunitUniRule annotation
    Gene namesi
    Name:hisZUniRule annotation
    Ordered Locus Names:BAB2_0182
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378ATP phosphoribosyltransferase regulatory subunitPRO_0000242825Add
    BLAST

    Interactioni

    Subunit structurei

    Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB2_0182.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3705.
    HOGENOMiHOG000141880.
    KOiK02502.
    OrthoDBiEOG6BPDH4.

    Family and domain databases

    HAMAPiMF_00125. HisZ.
    InterProiIPR004516. HisRS/HisZ.
    IPR004517. HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YIH8-1 [UniParc]FASTAAdd to Basket

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    MTMVGSRTSP IFNALRVELN AREAELVEIP LIQPADPFLD MAGEDLRRRI    50
    FLTENENGDS LCLRPEFTIP VCRNHIALNA ATPKRYAYLG EVFRQRRDGA 100
    AEFLQAGIED LGAADEAASD ARSLADALSC VKAIAPDAPL EIVLGDQSVF 150
    AGMLKALGLP QGWRKKLLRS FGDAHSMDLA LAELTGTQRR DPLPESLAVL 200
    VAEGDEIGLA RMLEAEMLEA GISPGAGRTP VEIARRLIEK EDLAATHFPA 250
    AALDLLRQFL AIRVSLDMAA VTLRAFAADN ALDLGAVLQK FEARADAIAQ 300
    AGIEMKDIIY DASFGRPLDY YTGLVYEIRD ASNRQDGVLA GGGRYDRLLT 350
    MLGACEAIPG VGFSIWLDRL QALAGEKQ 378
    Length:378
    Mass (Da):40,921
    Last modified:June 27, 2006 - v2
    Checksum:iE827A4A65543E4E2
    GO

    Sequence cautioni

    The sequence CAJ12348.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12348.1. Different initiation.
    RefSeqiYP_418411.1. NC_007624.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12348; CAJ12348; BAB2_0182.
    GeneIDi3827674.
    KEGGibmf:BAB2_0182.
    PATRICi17847870. VBIBruMel86222_2468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040265 Genomic DNA. Translation: CAJ12348.1 . Different initiation.
    RefSeqi YP_418411.1. NC_007624.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB2_0182.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12348 ; CAJ12348 ; BAB2_0182 .
    GeneIDi 3827674.
    KEGGi bmf:BAB2_0182.
    PATRICi 17847870. VBIBruMel86222_2468.

    Phylogenomic databases

    eggNOGi COG3705.
    HOGENOMi HOG000141880.
    KOi K02502.
    OrthoDBi EOG6BPDH4.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci BABO359391:GKDV-2425-MONOMER.
    BMEL359391:GJOQ-2425-MONOMER.

    Family and domain databases

    HAMAPi MF_00125. HisZ.
    InterProi IPR004516. HisRS/HisZ.
    IPR004517. HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiHISZ_BRUA2
    AccessioniPrimary (citable) accession number: Q2YIH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3