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Q2YIH8 (HISZ_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase regulatory subunit
Gene names
Name:hisZ
Ordered Locus Names:BAB2_0182
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine By similarity. HAMAP-Rule MF_00125

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00125

Subunit structure

Heteromultimer composed of HisG and HisZ subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00125.

Miscellaneous

This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.

Sequence caution

The sequence CAJ12348.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378ATP phosphoribosyltransferase regulatory subunit HAMAP-Rule MF_00125
PRO_0000242825

Sequences

Sequence LengthMass (Da)Tools
Q2YIH8 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: E827A4A65543E4E2

FASTA37840,921
        10         20         30         40         50         60 
MTMVGSRTSP IFNALRVELN AREAELVEIP LIQPADPFLD MAGEDLRRRI FLTENENGDS 

        70         80         90        100        110        120 
LCLRPEFTIP VCRNHIALNA ATPKRYAYLG EVFRQRRDGA AEFLQAGIED LGAADEAASD 

       130        140        150        160        170        180 
ARSLADALSC VKAIAPDAPL EIVLGDQSVF AGMLKALGLP QGWRKKLLRS FGDAHSMDLA 

       190        200        210        220        230        240 
LAELTGTQRR DPLPESLAVL VAEGDEIGLA RMLEAEMLEA GISPGAGRTP VEIARRLIEK 

       250        260        270        280        290        300 
EDLAATHFPA AALDLLRQFL AIRVSLDMAA VTLRAFAADN ALDLGAVLQK FEARADAIAQ 

       310        320        330        340        350        360 
AGIEMKDIIY DASFGRPLDY YTGLVYEIRD ASNRQDGVLA GGGRYDRLLT MLGACEAIPG 

       370 
VGFSIWLDRL QALAGEKQ 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040265 Genomic DNA. Translation: CAJ12348.1. Different initiation.
RefSeqYP_418411.1. NC_007624.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0182.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12348; CAJ12348; BAB2_0182.
GeneID3827674.
KEGGbmf:BAB2_0182.
PATRIC17847870. VBIBruMel86222_2468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3705.
HOGENOMHOG000141880.
KOK02502.
OrthoDBEOG6BPDH4.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2425-MONOMER.
BMEL359391:GJOQ-2425-MONOMER.
UniPathwayUPA00031; UER00006.

Family and domain databases

HAMAPMF_00125. HisZ.
InterProIPR004516. HisRS/HisZ.
IPR004517. HisRS/HisZ_bac.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHISZ_BRUA2
AccessionPrimary (citable) accession number: Q2YIH8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names