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Protein

ATP phosphoribosyltransferase regulatory subunit

Gene

hisZ

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.UniRule annotation

Pathway:iL-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2425-MONOMER.
BMEL359391:GJOQ-2425-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase regulatory subunitUniRule annotation
Gene namesi
Name:hisZUniRule annotation
Ordered Locus Names:BAB2_0182
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378ATP phosphoribosyltransferase regulatory subunitPRO_0000242825Add
BLAST

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG3705.
HOGENOMiHOG000141880.
KOiK02502.
OrthoDBiEOG6BPDH4.

Family and domain databases

HAMAPiMF_00125. HisZ.
InterProiIPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YIH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMVGSRTSP IFNALRVELN AREAELVEIP LIQPADPFLD MAGEDLRRRI
60 70 80 90 100
FLTENENGDS LCLRPEFTIP VCRNHIALNA ATPKRYAYLG EVFRQRRDGA
110 120 130 140 150
AEFLQAGIED LGAADEAASD ARSLADALSC VKAIAPDAPL EIVLGDQSVF
160 170 180 190 200
AGMLKALGLP QGWRKKLLRS FGDAHSMDLA LAELTGTQRR DPLPESLAVL
210 220 230 240 250
VAEGDEIGLA RMLEAEMLEA GISPGAGRTP VEIARRLIEK EDLAATHFPA
260 270 280 290 300
AALDLLRQFL AIRVSLDMAA VTLRAFAADN ALDLGAVLQK FEARADAIAQ
310 320 330 340 350
AGIEMKDIIY DASFGRPLDY YTGLVYEIRD ASNRQDGVLA GGGRYDRLLT
360 370
MLGACEAIPG VGFSIWLDRL QALAGEKQ
Length:378
Mass (Da):40,921
Last modified:June 27, 2006 - v2
Checksum:iE827A4A65543E4E2
GO

Sequence cautioni

The sequence CAJ12348.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12348.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiCAJ12348; CAJ12348; BAB2_0182.
KEGGibmf:BAB2_0182.
PATRICi17847870. VBIBruMel86222_2468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12348.1. Different initiation.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12348; CAJ12348; BAB2_0182.
KEGGibmf:BAB2_0182.
PATRICi17847870. VBIBruMel86222_2468.

Phylogenomic databases

eggNOGiCOG3705.
HOGENOMiHOG000141880.
KOiK02502.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006.
BioCyciBABO359391:GKDV-2425-MONOMER.
BMEL359391:GJOQ-2425-MONOMER.

Family and domain databases

HAMAPiMF_00125. HisZ.
InterProiIPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiHISZ_BRUA2
AccessioniPrimary (citable) accession number: Q2YIH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 22, 2015
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.