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Q2YIH2 (MUTL_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutL
Gene names
Name:mutL
Ordered Locus Names:BAB2_0212
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP-Rule MF_00149

Sequence similarities

Belongs to the DNA mismatch repair MutL/HexB family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623DNA mismatch repair protein MutL HAMAP-Rule MF_00149
PRO_1000009997

Sequences

Sequence LengthMass (Da)Tools
Q2YIH2 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 7CB97FEC4AE64BEF

FASTA62366,783
        10         20         30         40         50         60 
MTIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTAGGG KTLLRVTDNG 

        70         80         90        100        110        120 
SGIPADELAL AVSRHCTSKL TDDVHDIRAL GFRGEALPSI GSVSKLTLKS RPQDADSGFE 

       130        140        150        160        170        180 
VCVTGGHLDG PRPTALNRGT IVEVRDLFYA TPARLKFMKT DRAEATAITD VVKRIGIAFP 

       190        200        210        220        230        240 
HIRFSLAGTD RTPFEMPATG TGAEATLERI GQVLGREFGE NALAIDAERD GVRLAGFVGI 

       250        260        270        280        290        300 
PSFNRGNALH QFAYVNGRPV RDKQIFGALR GAYSDVIARD RHPVAVLFLT LDPALVDVNV 

       310        320        330        340        350        360 
HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAE AMLQAFRAEG FGAQQSAPRP 

       370        380        390        400        410        420 
ANSYSPASWR TAPPAPRSEW SPQTAHPAHR PLDLQAAPAL RENGQAVLGD VAVPAADARA 

       430        440        450        460        470        480 
SVAEAPVELM QKPLGAARAQ IHENYIVAQT EDSLVIVDQH AAHERLVYEA LKNALHARPI 

       490        500        510        520        530        540 
AGQMLLIPEI VDLPEEDAQR LAGHAETLAR FGLGVEQFGP GAIAVRETPA MLGEMNVQQL 

       550        560        570        580        590        600 
IRDLADEIAE HDTADGLKAM LHHVAATMAC HGSVRSGRRL KPEEMNALLR DMEATPGSGT 

       610        620 
CNHGRPTYIE LKLTDIERLF GRR 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040265 Genomic DNA. Translation: CAJ12378.1.
RefSeqYP_418438.1. NC_007624.1.

3D structure databases

ProteinModelPortalQ2YIH2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB2_0212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12378; CAJ12378; BAB2_0212.
GeneID3827922.
KEGGbmf:BAB2_0212.
PATRIC17847929. VBIBruMel86222_2497.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0323.
HOGENOMHOG000256550.
KOK03572.
OMAGTYILAQ.
OrthoDBEOG6P8TMH.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2455-MONOMER.
BMEL359391:GJOQ-2455-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPMF_00149. DNA_mis_repair.
InterProIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR011186. DNA_mismatch_repair_MLH1/HexB.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_ATP-bd.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR10073:SF12. PTHR10073:SF12. 1 hit.
PfamPF01119. DNA_mis_repair. 1 hit.
PF02518. HATPase_c. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTSM00387. HATPase_c. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsTIGR00585. mutl. 1 hit.
PROSITEPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTL_BRUA2
AccessionPrimary (citable) accession number: Q2YIH2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names