Q2YIH2 (MUTL_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutL

Gene names

Name:	mutL
Ordered Locus Names:	BAB2_0212

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP-Rule MF_00149
Sequence similarities	Belongs to the DNA mismatch repair MutL/HexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	DNA mismatch repair protein MutL HAMAP-Rule MF_00149		PRO_1000009997

Sequences

	Sequence		Length	Mass (Da)
	Q2YIH2 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 7CB97FEC4AE64BEF	FASTA	623	66,783
	10 20 30 40 50 60 MTIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTAGGG KTLLRVTDNG 70 80 90 100 110 120 SGIPADELAL AVSRHCTSKL TDDVHDIRAL GFRGEALPSI GSVSKLTLKS RPQDADSGFE 130 140 150 160 170 180 VCVTGGHLDG PRPTALNRGT IVEVRDLFYA TPARLKFMKT DRAEATAITD VVKRIGIAFP 190 200 210 220 230 240 HIRFSLAGTD RTPFEMPATG TGAEATLERI GQVLGREFGE NALAIDAERD GVRLAGFVGI 250 260 270 280 290 300 PSFNRGNALH QFAYVNGRPV RDKQIFGALR GAYSDVIARD RHPVAVLFLT LDPALVDVNV 310 320 330 340 350 360 HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAE AMLQAFRAEG FGAQQSAPRP 370 380 390 400 410 420 ANSYSPASWR TAPPAPRSEW SPQTAHPAHR PLDLQAAPAL RENGQAVLGD VAVPAADARA 430 440 450 460 470 480 SVAEAPVELM QKPLGAARAQ IHENYIVAQT EDSLVIVDQH AAHERLVYEA LKNALHARPI 490 500 510 520 530 540 AGQMLLIPEI VDLPEEDAQR LAGHAETLAR FGLGVEQFGP GAIAVRETPA MLGEMNVQQL 550 560 570 580 590 600 IRDLADEIAE HDTADGLKAM LHHVAATMAC HGSVRSGRRL KPEEMNALLR DMEATPGSGT 610 620 CNHGRPTYIE LKLTDIERLF GRR

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040265 Genomic DNA. Translation: CAJ12378.1.
RefSeq	YP_418438.1. NC_007624.1.
3D structure databases
ProteinModelPortal	Q2YIH2.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB2_0212.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ12378; CAJ12378; BAB2_0212.
GeneID	3827922.
KEGG	bmf:BAB2_0212.
PATRIC	17847929. VBIBruMel86222_2497.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HOG000256550.
KO	K03572.
OMA	FLFINNR.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-2455-MONOMER.
Family and domain databases
Gene3D	3.30.230.10. 1 hit. 3.30.565.10. 1 hit.
HAMAP	MF_00149. DNA_mis_repair.
InterPro	IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR003594. HATPase_ATP-bd. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
PANTHER	PTHR10073. PTHR10073. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_BRUA2

Accession

Primary (citable) accession number: Q2YIH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program