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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2455-MONOMER.
BMEL359391:GJOQ-2455-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:BAB2_0212
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623DNA mismatch repair protein MutLPRO_1000009997Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB2_0212.

Structurei

3D structure databases

ProteinModelPortaliQ2YIH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0323.
HOGENOMiHOG000256550.
KOiK03572.
OMAiFLFINNR.
OrthoDBiEOG6P8TMH.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR011186. DNA_mismatch_repair_MLH1/HexB.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10073:SF12. PTHR10073:SF12. 1 hit.
PfamiPF01119. DNA_mis_repair. 1 hit.
PF02518. HATPase_c. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YIH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTAGGG
60 70 80 90 100
KTLLRVTDNG SGIPADELAL AVSRHCTSKL TDDVHDIRAL GFRGEALPSI
110 120 130 140 150
GSVSKLTLKS RPQDADSGFE VCVTGGHLDG PRPTALNRGT IVEVRDLFYA
160 170 180 190 200
TPARLKFMKT DRAEATAITD VVKRIGIAFP HIRFSLAGTD RTPFEMPATG
210 220 230 240 250
TGAEATLERI GQVLGREFGE NALAIDAERD GVRLAGFVGI PSFNRGNALH
260 270 280 290 300
QFAYVNGRPV RDKQIFGALR GAYSDVIARD RHPVAVLFLT LDPALVDVNV
310 320 330 340 350
HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAE AMLQAFRAEG
360 370 380 390 400
FGAQQSAPRP ANSYSPASWR TAPPAPRSEW SPQTAHPAHR PLDLQAAPAL
410 420 430 440 450
RENGQAVLGD VAVPAADARA SVAEAPVELM QKPLGAARAQ IHENYIVAQT
460 470 480 490 500
EDSLVIVDQH AAHERLVYEA LKNALHARPI AGQMLLIPEI VDLPEEDAQR
510 520 530 540 550
LAGHAETLAR FGLGVEQFGP GAIAVRETPA MLGEMNVQQL IRDLADEIAE
560 570 580 590 600
HDTADGLKAM LHHVAATMAC HGSVRSGRRL KPEEMNALLR DMEATPGSGT
610 620
CNHGRPTYIE LKLTDIERLF GRR
Length:623
Mass (Da):66,783
Last modified:February 7, 2006 - v1
Checksum:i7CB97FEC4AE64BEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12378.1.
RefSeqiWP_002966364.1. NZ_KN046823.1.
YP_418438.1. NC_007624.1.

Genome annotation databases

EnsemblBacteriaiCAJ12378; CAJ12378; BAB2_0212.
GeneIDi3827922.
KEGGibmf:BAB2_0212.
PATRICi17847929. VBIBruMel86222_2497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040265 Genomic DNA. Translation: CAJ12378.1.
RefSeqiWP_002966364.1. NZ_KN046823.1.
YP_418438.1. NC_007624.1.

3D structure databases

ProteinModelPortaliQ2YIH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB2_0212.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12378; CAJ12378; BAB2_0212.
GeneIDi3827922.
KEGGibmf:BAB2_0212.
PATRICi17847929. VBIBruMel86222_2497.

Phylogenomic databases

eggNOGiCOG0323.
HOGENOMiHOG000256550.
KOiK03572.
OMAiFLFINNR.
OrthoDBiEOG6P8TMH.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2455-MONOMER.
BMEL359391:GJOQ-2455-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR011186. DNA_mismatch_repair_MLH1/HexB.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10073:SF12. PTHR10073:SF12. 1 hit.
PfamiPF01119. DNA_mis_repair. 1 hit.
PF02518. HATPase_c. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiMUTL_BRUA2
AccessioniPrimary (citable) accession number: Q2YIH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.