Q2YFE1 (Q2YFE1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Integrin beta RuleBase RU000633
Organism	Homo sapiens (Human) EMBL AAX33645.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU000633.
Sequence similarities	Belongs to the integrin beta chain family. RuleBase RU000633

Ontologies

Keywords
Biological process	Cell adhesion RuleBase RU000633
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000633
Molecular function	Integrin RuleBase RU000633 EMBL AAX33645.1
Gene Ontology (GO)
Biological_process	angiogenesis involved in wound healing Inferred from electronic annotation. Source: InterPro cell-matrix adhesion Inferred from electronic annotation. Source: InterPro cell-substrate junction assembly Inferred from electronic annotation. Source: InterPro integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW platelet aggregation Inferred from electronic annotation. Source: InterPro regulation of cell migration Inferred from electronic annotation. Source: InterPro
Cellular_component	integrin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2YFE1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 447CBBB73BCFEC78	FASTA	443	48,644
	10 20 30 40 50 60 MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPPG 70 80 90 100 110 120 SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP 130 140 150 160 170 180 DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG 190 200 210 220 230 240 AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR 250 260 270 280 290 300 NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH 310 320 330 340 350 360 VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS 370 380 390 400 410 420 MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT 430 440 VRWAGQGLCP GASVGTQPPF FLL

References

[1]	"Role of a truncated beta 3 integrin in tumor cell migration: a novel mechanism of tumor metastasis." Jin R., Trikha M., Cai Y., Grignon D., Honn K.V. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY826979 mRNA. Translation: AAX33645.1.
IPI	IPI01015923.
UniGene	Hs.218040.
3D structure databases
ProteinModelPortal	Q2YFE1.
SMR	Q2YFE1. Positions 27-424.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YFE1.
Proteomic databases
PRIDE	Q2YFE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc002ili.1. human.
Phylogenomic databases
HOVERGEN	HBG075699.
Gene expression databases
ArrayExpress	Q2YFE1.
Family and domain databases
InterPro	IPR027068. Integrin_beta-3. IPR015812. Integrin_bsu. IPR002369. Integrin_bsu_N. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002035. VWF_A. [Graphical view]
PANTHER	PTHR10082. PTHR10082. 1 hit. PTHR10082:SF25. PTHR10082:SF25. 1 hit.
Pfam	PF00362. Integrin_beta. 1 hit. [Graphical view]
PRINTS	PR01186. INTEGRINB.
SMART	SM00187. INB. 1 hit. SM00423. PSI. 1 hit. SM00327. VWA. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2YFE1_HUMAN

Accession

Primary (citable) accession number: Q2YFE1

Entry history

Integrated into UniProtKB/TrEMBL:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.