Reviewed, UniProtKB/Swiss-Prot O95760 (IL33_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-33
      Short name=IL-33
Alternative name(s):
    Interleukin-1 family member 11
      Short name=IL-1F11
    Nuclear factor from high endothelial venules
      Short name=NF-HEV

Gene names

Name:	IL33
Synonyms:	C9orf26, IL1F11, NFHEV

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines.
Subcellular location	Secreted.
Tissue specificity	Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Post-translational modification	Proteolytically converted to a mature form by CASP1.
Sequence similarities	Belongs to the IL-1 family. Highly divergent.
Caution	Was originally (Ref.1) thought to one of the key factors that controls the specialized post-capillary high endothelial venules (HEV) phenotype found in organized secondary lymphoid tissue and to be nuclear localized.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Cytokine
Gene Ontology (GO)
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IL1RL1	Q01638	2	EBI-724057,EBI-993762

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – ?		Potential		PRO_0000248845
	Chain	? – 270		Interleukin-33		PRO_0000096790

Sequences

	Sequence		Length	Mass (Da)
	O95760-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 7C158069196EF636	FASTA	270	30,759
	10 20 30 40 50 60 MKPKMKYSTN KISTAKWKNT ASKALCFKLG KSQQKAKEVC PMYFMKLRSG LMIKKEACYF 70 80 90 100 110 120 RRETTKRPSL KTGRKHKRHL VLAACQQQST VECFAFGISG VQKYTRALHD SSITGISPIT 130 140 150 160 170 180 EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK 190 200 210 220 230 240 MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI 250 260 270 GVKDNHLALI KVDSSENLCT ENILFKLSET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules." Baekkevold E.S., Roussigne M., Yamanaka T., Johansen F.-E., Jahnsen F.L., Amalric F., Brandtzaeg P., Erard M., Haraldsen G., Girard J.-P. Am. J. Pathol. 163:69-79(2003) [PubMed: 12819012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, CHARACTERIZATION, SUBCELLULAR LOCATION. Tissue: Endothelial cell.
[2]	"Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage." Onda H., Kasuya H., Takakura K., Hori T., Imaizumi T., Takeuchi T., Inoue I., Takeda J. J. Cereb. Blood Flow Metab. 19:1279-1288(1999) [PubMed: 10566975] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines." Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., Zurawski G., Moshrefi M., Qin J., Li X., Gorman D.M., Bazan J.F., Kastelein R.A. Immunity 23:479-490(2005) [PubMed: 16286016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING, FUNCTION.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB024518 mRNA. Translation: BAA75892.1. AY905581 mRNA. Translation: AAX86998.1. CR407619 mRNA. Translation: CAG28547.1. AL353741 Genomic DNA. Translation: CAI16003.1. BC047085 mRNA. Translation: AAH47085.1.
RefSeq	NP_254274.1.
UniGene	Hs.348390
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O95760.
PTM databases
PhosphoSite	O95760.
Genome annotation databases
Ensembl	ENSG00000137033. Homo sapiens. [Contig view]
GeneID	90865.
KEGG	hsa:90865.
Organism-specific databases
H-InvDB	HIX0007907.
HGNC	HGNC:16028. IL33.
HPA	CAB007057.
MIM	608678. gene.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	O95760.
HOVERGEN	O95760.
Gene expression databases
ArrayExpress	O95760.
CleanEx	HS_IL33.
GermOnline	ENSG00000137033. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	77016.
SOURCE	Search...

Entry information

Entry name

IL33_HUMAN

Accession

Primary (citable) accession number: O95760
Secondary accession number(s): Q2YEJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	May 1, 1999
Last modified:	November 25, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)