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Q2YEG0 (CXCR1_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 1

Short name=CXC-R1
Short name=CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name=IL-8R A
IL-8 receptor type 1
CD_antigen=CD181
Gene names
Name:CXCR1
Synonyms:IL8RA
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351C-X-C chemokine receptor type 1
PRO_0000237619

Regions

Topological domain1 – 4646Extracellular Potential
Transmembrane47 – 6721Helical; Name=1; Potential
Topological domain68 – 769Cytoplasmic Potential
Transmembrane77 – 9721Helical; Name=2; Potential
Topological domain98 – 11215Extracellular Potential
Transmembrane113 – 13321Helical; Name=3; Potential
Topological domain134 – 15421Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20429Extracellular Potential
Transmembrane205 – 22521Helical; Name=5; Potential
Topological domain226 – 24318Cytoplasmic Potential
Transmembrane244 – 26421Helical; Name=6; Potential
Topological domain265 – 28925Extracellular Potential
Transmembrane290 – 31021Helical; Name=7; Potential
Topological domain311 – 35141Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 188 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YEG0 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 050FDC46423AD4A1

FASTA35139,811
        10         20         30         40         50         60 
MSNATDPQMG DDDYDLNFTG MPPTDEDYSP CRLETQSLNK YVVIVTYALV FLLSLLGNSL 

        70         80         90        100        110        120 
VMLVILYRRV GRSVTDVYLL NLAMADLLFA LTLPIWAASK VNGWIFGTFL CKVVSLLKEV 

       130        140        150        160        170        180 
NFYSGILLLA CISVDRYLAI VHATRTLIQK RHSVKFVCLS CWGLSVILSL PFFLFRQAYH 

       190        200        210        220        230        240 
PNNSTPVCYE VLGNDTAKWR MVLRILPHTF GFTLPLLIML FCYGFTLHTL FKAHIGQKHR 

       250        260        270        280        290        300 
AMRVIFAVVL IFLLCWLPYN LVLLADTLMR THLIKESCER RNDIGRALDA TEILGFLHSC 

       310        320        330        340        350 
LNPIIYAFIG QNFRHGFLKI LATHGLVSKE FLARHHVTSY TSSSVNVSSN L 

« Hide

References

[1]"Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY916770 Genomic DNA. Translation: AAY21520.1.
RefSeqNP_001035510.1. NM_001040420.1.
UniGeneMmu.9522.

3D structure databases

ProteinModelPortalQ2YEG0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000025429.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000027182; ENSMMUP00000025429; ENSMMUG00000019351.
GeneID692074.
KEGGmcc:692074.

Organism-specific databases

CTD3577.

Phylogenomic databases

eggNOGNOG146068.
GeneTreeENSGT00730000110292.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ2YEG0.
KOK04175.
OMAPVCYEVL.
OrthoDBEOG7ZPNK9.
TreeFamTF330966.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19971946.

Entry information

Entry nameCXCR1_MACMU
AccessionPrimary (citable) accession number: Q2YEG0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries