Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2YEG0

- CXCR1_MACMU

UniProt

Q2YEG0 - CXCR1_MACMU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity (By similarity).By similarity

GO - Molecular functioni

  1. interleukin-8 receptor activity Source: Ensembl

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
  2. receptor internalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:IL8RA
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 12

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351C-X-C chemokine receptor type 1PRO_0000237619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000025429.

Structurei

3D structure databases

ProteinModelPortaliQ2YEG0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
BLAST
Topological domaini68 – 769CytoplasmicSequence Analysis
Topological domaini98 – 11215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini176 – 20429ExtracellularSequence AnalysisAdd
BLAST
Topological domaini226 – 24318CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini265 – 28925ExtracellularSequence AnalysisAdd
BLAST
Topological domaini311 – 35141CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ2YEG0.
KOiK04175.
OMAiPVCYEVL.
OrthoDBiEOG7ZPNK9.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YEG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNATDPQMG DDDYDLNFTG MPPTDEDYSP CRLETQSLNK YVVIVTYALV
60 70 80 90 100
FLLSLLGNSL VMLVILYRRV GRSVTDVYLL NLAMADLLFA LTLPIWAASK
110 120 130 140 150
VNGWIFGTFL CKVVSLLKEV NFYSGILLLA CISVDRYLAI VHATRTLIQK
160 170 180 190 200
RHSVKFVCLS CWGLSVILSL PFFLFRQAYH PNNSTPVCYE VLGNDTAKWR
210 220 230 240 250
MVLRILPHTF GFTLPLLIML FCYGFTLHTL FKAHIGQKHR AMRVIFAVVL
260 270 280 290 300
IFLLCWLPYN LVLLADTLMR THLIKESCER RNDIGRALDA TEILGFLHSC
310 320 330 340 350
LNPIIYAFIG QNFRHGFLKI LATHGLVSKE FLARHHVTSY TSSSVNVSSN

L
Length:351
Mass (Da):39,811
Last modified:December 20, 2005 - v1
Checksum:i050FDC46423AD4A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY916770 Genomic DNA. Translation: AAY21520.1.
RefSeqiNP_001035510.1. NM_001040420.1.
UniGeneiMmu.9522.

Genome annotation databases

EnsembliENSMMUT00000027182; ENSMMUP00000025429; ENSMMUG00000019351.
GeneIDi692074.
KEGGimcc:692074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY916770 Genomic DNA. Translation: AAY21520.1 .
RefSeqi NP_001035510.1. NM_001040420.1.
UniGenei Mmu.9522.

3D structure databases

ProteinModelPortali Q2YEG0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000025429.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000027182 ; ENSMMUP00000025429 ; ENSMMUG00000019351 .
GeneIDi 692074.
KEGGi mcc:692074.

Organism-specific databases

CTDi 3577.

Phylogenomic databases

eggNOGi NOG146068.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi Q2YEG0.
KOi K04175.
OMAi PVCYEVL.
OrthoDBi EOG7ZPNK9.
TreeFami TF330966.

Miscellaneous databases

NextBioi 19971946.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
    Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
    J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCXCR1_MACMU
AccessioniPrimary (citable) accession number: Q2YEG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3