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Q2YEG0

- CXCR1_MACMU

UniProt

Q2YEG0 - CXCR1_MACMU

Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-8 receptor activity Source: Ensembl

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW
    2. receptor internalization Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 1
    Short name:
    CXC-R1
    Short name:
    CXCR-1
    Alternative name(s):
    High affinity interleukin-8 receptor A
    Short name:
    IL-8R A
    IL-8 receptor type 1
    CD_antigen: CD181
    Gene namesi
    Name:CXCR1
    Synonyms:IL8RA
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 12

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351C-X-C chemokine receptor type 1PRO_0000237619Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000025429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YEG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 769CytoplasmicSequence Analysis
    Topological domaini98 – 11215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20429ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 24318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28925ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 35141CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146068.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ2YEG0.
    KOiK04175.
    OMAiPVCYEVL.
    OrthoDBiEOG7ZPNK9.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00572. INTRLEUKN8AR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YEG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNATDPQMG DDDYDLNFTG MPPTDEDYSP CRLETQSLNK YVVIVTYALV    50
    FLLSLLGNSL VMLVILYRRV GRSVTDVYLL NLAMADLLFA LTLPIWAASK 100
    VNGWIFGTFL CKVVSLLKEV NFYSGILLLA CISVDRYLAI VHATRTLIQK 150
    RHSVKFVCLS CWGLSVILSL PFFLFRQAYH PNNSTPVCYE VLGNDTAKWR 200
    MVLRILPHTF GFTLPLLIML FCYGFTLHTL FKAHIGQKHR AMRVIFAVVL 250
    IFLLCWLPYN LVLLADTLMR THLIKESCER RNDIGRALDA TEILGFLHSC 300
    LNPIIYAFIG QNFRHGFLKI LATHGLVSKE FLARHHVTSY TSSSVNVSSN 350
    L 351
    Length:351
    Mass (Da):39,811
    Last modified:December 20, 2005 - v1
    Checksum:i050FDC46423AD4A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY916770 Genomic DNA. Translation: AAY21520.1.
    RefSeqiNP_001035510.1. NM_001040420.1.
    UniGeneiMmu.9522.

    Genome annotation databases

    EnsembliENSMMUT00000027182; ENSMMUP00000025429; ENSMMUG00000019351.
    GeneIDi692074.
    KEGGimcc:692074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY916770 Genomic DNA. Translation: AAY21520.1 .
    RefSeqi NP_001035510.1. NM_001040420.1.
    UniGenei Mmu.9522.

    3D structure databases

    ProteinModelPortali Q2YEG0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000025429.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000027182 ; ENSMMUP00000025429 ; ENSMMUG00000019351 .
    GeneIDi 692074.
    KEGGi mcc:692074.

    Organism-specific databases

    CTDi 3577.

    Phylogenomic databases

    eggNOGi NOG146068.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q2YEG0.
    KOi K04175.
    OMAi PVCYEVL.
    OrthoDBi EOG7ZPNK9.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 19971946.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00572. INTRLEUKN8AR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
      Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
      J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCXCR1_MACMU
    AccessioniPrimary (citable) accession number: Q2YEG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3