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Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:IL8RA
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini68 – 769CytoplasmicSequence Analysis
Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini98 – 11215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 20429ExtracellularSequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 24318CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 28925ExtracellularSequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini311 – 35141CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351C-X-C chemokine receptor type 1PRO_0000237619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 188PROSITE-ProRule annotation
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000025429.

Structurei

3D structure databases

ProteinModelPortaliQ2YEG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ2YEG0.
KOiK04175.
OMAiLFRQAYH.
OrthoDBiEOG7ZPNK9.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YEG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNATDPQMG DDDYDLNFTG MPPTDEDYSP CRLETQSLNK YVVIVTYALV
60 70 80 90 100
FLLSLLGNSL VMLVILYRRV GRSVTDVYLL NLAMADLLFA LTLPIWAASK
110 120 130 140 150
VNGWIFGTFL CKVVSLLKEV NFYSGILLLA CISVDRYLAI VHATRTLIQK
160 170 180 190 200
RHSVKFVCLS CWGLSVILSL PFFLFRQAYH PNNSTPVCYE VLGNDTAKWR
210 220 230 240 250
MVLRILPHTF GFTLPLLIML FCYGFTLHTL FKAHIGQKHR AMRVIFAVVL
260 270 280 290 300
IFLLCWLPYN LVLLADTLMR THLIKESCER RNDIGRALDA TEILGFLHSC
310 320 330 340 350
LNPIIYAFIG QNFRHGFLKI LATHGLVSKE FLARHHVTSY TSSSVNVSSN

L
Length:351
Mass (Da):39,811
Last modified:December 20, 2005 - v1
Checksum:i050FDC46423AD4A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916770 Genomic DNA. Translation: AAY21520.1.
RefSeqiNP_001035510.1. NM_001040420.1.
UniGeneiMmu.9522.

Genome annotation databases

EnsembliENSMMUT00000027182; ENSMMUP00000025429; ENSMMUG00000019351.
GeneIDi692074.
KEGGimcc:692074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916770 Genomic DNA. Translation: AAY21520.1.
RefSeqiNP_001035510.1. NM_001040420.1.
UniGeneiMmu.9522.

3D structure databases

ProteinModelPortaliQ2YEG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000025429.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000027182; ENSMMUP00000025429; ENSMMUG00000019351.
GeneIDi692074.
KEGGimcc:692074.

Organism-specific databases

CTDi3577.

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ2YEG0.
KOiK04175.
OMAiLFRQAYH.
OrthoDBiEOG7ZPNK9.
TreeFamiTF330966.

Miscellaneous databases

NextBioi19971946.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
    Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
    J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCXCR1_MACMU
AccessioniPrimary (citable) accession number: Q2YEG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.