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Protein

Protein misato homolog 1

Gene

Msto1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of mitochondrial distribution and morphology.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein misato homolog 1
Gene namesi
Name:Msto1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2385175. Msto1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Protein misato homolog 1PRO_0000304628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ2YDW2.
MaxQBiQ2YDW2.
PaxDbiQ2YDW2.
PRIDEiQ2YDW2.

PTM databases

iPTMnetiQ2YDW2.
PhosphoSiteiQ2YDW2.

Expressioni

Gene expression databases

CleanExiMM_MSTO1.

Interactioni

Protein-protein interaction databases

IntActiQ2YDW2. 1 interaction.
STRINGi10090.ENSMUSP00000115645.

Structurei

3D structure databases

ProteinModelPortaliQ2YDW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the misato family.Curated

Phylogenomic databases

eggNOGiKOG2530. Eukaryota.
ENOG410XPM0. LUCA.
HOGENOMiHOG000008060.
HOVERGENiHBG108151.
InParanoidiQ2YDW2.

Family and domain databases

Gene3Di3.40.50.1440. 2 hits.
InterProiIPR029209. DML1/Misato_tubulin.
IPR019605. Misato_II_tubulin-like.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF10644. Misat_Tub_SegII. 1 hit.
PF14881. Tubulin_3. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2YDW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGAREVLT LQLGHFAGFV GAHWWNQQDA ALGRMAEDEE SPGELCPDVL
60 70 80 90 100
YRTGRTLHGQ ETYTPRLILM DLKGSLNTLK EEGNLYRDRQ LEAAVAWQGK
110 120 130 140 150
LSTHREDAHP KNPNLQGLLS AEGVRSSDGA WRAKLIQNIQ NGKENSIKVW
160 170 180 190 200
SDFLRVHLHP RSICVIHKYH HDGETGRLEA FGQGESVLKE PRYLEELEDR
210 220 230 240 250
LHFYVEECDY LQGFQLLCDL HDGFSGVGAK TAELLQDEYA GRGVLTWGLL
260 270 280 290 300
PGPYSLGEPQ KNIYRLLNTA FGLVHLTGYS SFVCPLSLGG NLGLRPKPPV
310 320 330 340 350
NFPSLHYDAT LPFHCSAILA TALDTVTVPY RLRSSMVTMA HLADVLSFSG
360 370 380 390 400
KKVVTAEAII PFPLVRGQSL PDILTQLGEA TPWTSLSACG DSAGHRCFAQ
410 420 430 440 450
SVVLRGIDRA SHTSKLNPGT PLPSALHACA SGEEVLAQYL QQQHPRVLSS
460 470 480 490 500
SHLLLTPCKV APPYPHFFSS FSQKGLAMDS TPKGAAVQSI PVFGALRSTS
510 520 530 540 550
SLHRTLGDLA EELSRLDLRR WASFMDAGVE QDDMEEMLHE LHRLAQCYQE

GDSLSN
Length:556
Mass (Da):61,230
Last modified:December 20, 2005 - v1
Checksum:iF7611F673290C3CC
GO
Isoform 2 (identifier: Q2YDW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-475: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):49,287
Checksum:i8ECD9938135169ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231H → D in BAE37273 (PubMed:16141072).Curated
Sequence conflicti106 – 1061E → D in BAE37273 (PubMed:16141072).Curated
Sequence conflicti106 – 1061E → D in BAE39645 (PubMed:16141072).Curated
Sequence conflicti109 – 1091H → Q in BAE37273 (PubMed:16141072).Curated
Sequence conflicti109 – 1091H → Q in BAE39645 (PubMed:16141072).Curated
Sequence conflicti109 – 1091H → Q in AAH08103 (PubMed:15489334).Curated
Sequence conflicti228 – 2281G → S in BAE38651 (PubMed:16141072).Curated
Sequence conflicti365 – 3651V → A in BAE38651 (PubMed:16141072).Curated
Sequence conflicti553 – 5531S → T in BAE38651 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei364 – 475112Missing in isoform 2. 1 PublicationVSP_028057Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163280 mRNA. Translation: BAE37273.1.
AK166236 mRNA. Translation: BAE38651.1.
AK167586 mRNA. Translation: BAE39645.1.
BC008103 mRNA. Translation: AAH08103.1.
BC108354 mRNA. Translation: AAI08355.1.
CCDSiCCDS17485.1. [Q2YDW2-1]
RefSeqiNP_659147.2. NM_144898.2.
UniGeneiMm.440405.

Genome annotation databases

GeneIDi229524.
KEGGimmu:229524.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163280 mRNA. Translation: BAE37273.1.
AK166236 mRNA. Translation: BAE38651.1.
AK167586 mRNA. Translation: BAE39645.1.
BC008103 mRNA. Translation: AAH08103.1.
BC108354 mRNA. Translation: AAI08355.1.
CCDSiCCDS17485.1. [Q2YDW2-1]
RefSeqiNP_659147.2. NM_144898.2.
UniGeneiMm.440405.

3D structure databases

ProteinModelPortaliQ2YDW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2YDW2. 1 interaction.
STRINGi10090.ENSMUSP00000115645.

PTM databases

iPTMnetiQ2YDW2.
PhosphoSiteiQ2YDW2.

Proteomic databases

EPDiQ2YDW2.
MaxQBiQ2YDW2.
PaxDbiQ2YDW2.
PRIDEiQ2YDW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi229524.
KEGGimmu:229524.

Organism-specific databases

CTDi55154.
MGIiMGI:2385175. Msto1.

Phylogenomic databases

eggNOGiKOG2530. Eukaryota.
ENOG410XPM0. LUCA.
HOGENOMiHOG000008060.
HOVERGENiHBG108151.
InParanoidiQ2YDW2.

Miscellaneous databases

PROiQ2YDW2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MSTO1.

Family and domain databases

Gene3Di3.40.50.1440. 2 hits.
InterProiIPR029209. DML1/Misato_tubulin.
IPR019605. Misato_II_tubulin-like.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF10644. Misat_Tub_SegII. 1 hit.
PF14881. Tubulin_3. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Egg, Mammary gland and Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Spleen and Testis.

Entry informationi

Entry nameiMSTO1_MOUSE
AccessioniPrimary (citable) accession number: Q2YDW2
Secondary accession number(s): Q3TJ50
, Q3TLZ1, Q3TQV9, Q922H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 20, 2005
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.