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Q2YDR3 (IMPA3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol monophosphatase 3
Short name=IMP 3
Short name=IMPase 3
EC=3.1.3.25
Alternative name(s):
Inositol monophosphatase domain-containing protein 1
Inositol-1(or 4)-monophosphatase 3
Myo-inositol monophosphatase A3
Gene names
Name:impad1
Synonyms:impa3
ORF Names:zgc:123256
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the inositol monophosphatase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioninositol monophosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Inositol monophosphatase 3
PRO_0000289043

Regions

Transmembrane11 – 3121Helical; Potential
Region159 – 1624Substrate binding By similarity

Sites

Metal binding1171Magnesium 1 By similarity
Metal binding1571Magnesium 1 By similarity
Metal binding1571Magnesium 2 By similarity
Metal binding1591Magnesium 1; via carbonyl oxygen By similarity
Metal binding1601Magnesium 2 By similarity
Metal binding2831Magnesium 2 By similarity
Binding site1171Substrate By similarity
Binding site2831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YDR3 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 998D9833143F1904

FASTA34137,432
        10         20         30         40         50         60 
MAPMGIRLSP LGIAVFCLLG VGVIYHLYAG VLSSRLAFFR QKRTVDLREL LALSIDAAVQ 

        70         80         90        100        110        120 
GGREVKRIRE DNTLEEKSKG KTKEGASEKY TLGDLNSHRK MYYLIKNTFP NIQVNSEEHA 

       130        140        150        160        170        180 
NAEGEATVWT RMIPEDILAK VSGGKEIPAE KITVWIDPLD ATQEYTENLL KYVTTMVCVA 

       190        200        210        220        230        240 
VDGEPVIGVI HKPFTGYTVW GFVGEGSNVA PRDSYNTNSP KVIVSRSHAG KVKSFVQTAF 

       250        260        270        280        290        300 
GNNTEIIPAG GAGYKALALL NPTDDKQETA DIYIHVTYIK KWDICAGDAI LKSLGGQMTT 

       310        320        330        340 
LKGEQIDYSG LEGNKGGLLA SMKVDHKALV KRLPLWEDNK Q

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC110106 mRNA. Translation: AAI10107.1.
IPIIPI00679262.
RefSeqNP_001032657.1. NM_001037568.1.
UniGeneDr.88897.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2YDR3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000080925; ENSDARP00000075369; ENSDARG00000058114.
GeneID641570.
KEGGdre:641570.

Organism-specific databases

CTD54928.
ZFINZDB-GENE-051127-23. zgc:123256.

Phylogenomic databases

eggNOGfiNOG12215.
GeneTreeENSGT00530000063462.
HOGENOMHBG717298.
HOVERGENHBG062091.
InParanoidQ2YDR3.
OMANVQINTE.
OrthoDBEOG434W6B.

Gene expression databases

BgeeQ2YDR3.

Family and domain databases

InterProIPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
KOK01092.
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEPS00629. IMP_1. False negative.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIMPA3_DANRE
AccessionPrimary (citable) accession number: Q2YDR3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 20, 2005
Last modified: November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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