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Q2YDL5

- FKB11_BOVIN

UniProt

Q2YDL5 - FKB11_BOVIN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP11

Gene

FKBP11

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP11 (EC:5.2.1.8)
    Short name:
    PPIase FKBP11
    Alternative name(s):
    FK506-binding protein 11
    Short name:
    FKBP-11
    Rotamase
    Gene namesi
    Name:FKBP11
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 203174Peptidyl-prolyl cis-trans isomerase FKBP11PRO_0000285595Add
    BLAST

    Proteomic databases

    PaxDbiQ2YDL5.
    PRIDEiQ2YDL5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000021025.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 14688PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    HOVERGENiHBG051623.
    InParanoidiQ2YDL5.
    KOiK09576.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2YDL5-1 [UniParc]FASTAAdd to Basket

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    MTLRPSLLPL RLLLLLLLLL RGAVCQAEAG SETESPVRTL QVETLVEPPE    50
    PCAEPATFGD TLHIHYSGSL VDGRIFDTSL TRDPLVIELG QKQVIPGLEQ 100
    SLLDMCVGEK RRVIIPSHLA YGKRGFPPSI PADAELHFDV ELIALIRANY 150
    WQKLVKGILP LVGMAMVPAL LGLIGYHLYR KASSPKISKN KLKEEKRNKS 200
    KKK 203
    Length:203
    Mass (Da):22,475
    Last modified:December 20, 2005 - v1
    Checksum:i62345FFA86344A45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC110165 mRNA. Translation: AAI10166.1.
    RefSeqiNP_001039397.1. NM_001045932.1.
    UniGeneiBt.55432.

    Genome annotation databases

    GeneIDi506043.
    KEGGibta:506043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC110165 mRNA. Translation: AAI10166.1 .
    RefSeqi NP_001039397.1. NM_001045932.1.
    UniGenei Bt.55432.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000021025.

    Proteomic databases

    PaxDbi Q2YDL5.
    PRIDEi Q2YDL5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 506043.
    KEGGi bta:506043.

    Organism-specific databases

    CTDi 51303.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    HOVERGENi HBG051623.
    InParanoidi Q2YDL5.
    KOi K09576.

    Miscellaneous databases

    NextBioi 20867422.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiFKB11_BOVIN
    AccessioniPrimary (citable) accession number: Q2YDL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3