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Q2YDL5

- FKB11_BOVIN

UniProt

Q2YDL5 - FKB11_BOVIN

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Protein

Peptidyl-prolyl cis-trans isomerase FKBP11

Gene

FKBP11

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP11 (EC:5.2.1.8)
Short name:
PPIase FKBP11
Alternative name(s):
FK506-binding protein 11
Short name:
FKBP-11
Rotamase
Gene namesi
Name:FKBP11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 203174Peptidyl-prolyl cis-trans isomerase FKBP11PRO_0000285595Add
BLAST

Proteomic databases

PaxDbiQ2YDL5.
PRIDEiQ2YDL5.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021025.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 14688PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ2YDL5.
KOiK09576.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YDL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLRPSLLPL RLLLLLLLLL RGAVCQAEAG SETESPVRTL QVETLVEPPE
60 70 80 90 100
PCAEPATFGD TLHIHYSGSL VDGRIFDTSL TRDPLVIELG QKQVIPGLEQ
110 120 130 140 150
SLLDMCVGEK RRVIIPSHLA YGKRGFPPSI PADAELHFDV ELIALIRANY
160 170 180 190 200
WQKLVKGILP LVGMAMVPAL LGLIGYHLYR KASSPKISKN KLKEEKRNKS

KKK
Length:203
Mass (Da):22,475
Last modified:December 20, 2005 - v1
Checksum:i62345FFA86344A45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110165 mRNA. Translation: AAI10166.1.
RefSeqiNP_001039397.1. NM_001045932.1.
UniGeneiBt.55432.

Genome annotation databases

GeneIDi506043.
KEGGibta:506043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110165 mRNA. Translation: AAI10166.1 .
RefSeqi NP_001039397.1. NM_001045932.1.
UniGenei Bt.55432.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000021025.

Proteomic databases

PaxDbi Q2YDL5.
PRIDEi Q2YDL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 506043.
KEGGi bta:506043.

Organism-specific databases

CTDi 51303.

Phylogenomic databases

eggNOGi COG0545.
HOGENOMi HOG000154887.
HOVERGENi HBG051623.
InParanoidi Q2YDL5.
KOi K09576.

Miscellaneous databases

NextBioi 20867422.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiFKB11_BOVIN
AccessioniPrimary (citable) accession number: Q2YDL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 20, 2005
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3