Q2YDL5 (FKB11_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP11
Short name=PPIase FKBP11
EC=5.2.1.8

Alternative name(s):
FK506-binding protein 11
Short name=FKBP-11
Rotamase

Gene names

Name:

FKBP11

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins during protein synthesis By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FK506 binding Inferred from sequence or structural similarity. Source: RefGenome peptidyl-prolyl cis-trans isomerase activity Inferred from sequence or structural similarity. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 203	174	Peptidyl-prolyl cis-trans isomerase FKBP11		PRO_0000285595
Regions
	Transmembrane	158 – 178	21	Helical; Potential
	Domain	59 – 146	88	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	Q2YDL5 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 62345FFA86344A45	FASTA	203	22,475
	10 20 30 40 50 60 MTLRPSLLPL RLLLLLLLLL RGAVCQAEAG SETESPVRTL QVETLVEPPE PCAEPATFGD 70 80 90 100 110 120 TLHIHYSGSL VDGRIFDTSL TRDPLVIELG QKQVIPGLEQ SLLDMCVGEK RRVIIPSHLA 130 140 150 160 170 180 YGKRGFPPSI PADAELHFDV ELIALIRANY WQKLVKGILP LVGMAMVPAL LGLIGYHLYR 190 200 KASSPKISKN KLKEEKRNKS KKK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC110165 mRNA. Translation: AAI10166.1.
IPI	IPI00689629.
RefSeq	NP_001039397.1. NM_001045932.1.
UniGene	Bt.55432.
3D structure databases
HSSP	HSSP built from PDB template 2DG9 based on UniProtKB P62942.
ModBase	Search...
Proteomic databases
PRIDE	Q2YDL5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	506043.
KEGG	bta:506043.
Organism-specific databases
CTD	51303.
Phylogenomic databases
eggNOG	maNOG17937.
GeneTree	ENSGT00530000062784.
HOVERGEN	HBG051623.
InParanoid	Q2YDL5.
OrthoDB	EOG4T784J.
PhylomeDB	Q2YDL5.
Family and domain databases
InterPro	IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view]
KO	K09576.
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKB11_BOVIN

Accession

Primary (citable) accession number: Q2YDL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	December 20, 2005
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program