Reviewed, UniProtKB/Swiss-Prot Q2YDJ9 (GMPPB_BOVIN)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase beta
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase beta
    GDP-mannose pyrophosphorylase B

Gene names

Name:

GMPPB

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Mannose-1-phosphate guanyltransferase beta		PRO_0000307161

Sequences

	Sequence		Length	Mass (Da)
	Q2YDJ9-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 5C240179793A8712	FASTA	360	39,837
	10 20 30 40 50 60 MKALILVGGY GTRLRPLTLS IPKPLADFCN KPILLHQVEA LAAAGVDHVI LAVSYMSQVL 70 80 90 100 110 120 EKEMKAQEQK LGIRISMSHE EEPLGTAGPL ALARDLLCET ADPFFVLNSD VICDFPFEAM 130 140 150 160 170 180 VQFHRHHGQE GSILVTKVEE PSKYGVVVCE ADTGRVHRFV EKPQVFVSNK INAGVYILSP 190 200 210 220 230 240 SVLRRIQLQP TSIEKEIFPV MAKEGQLYAM ELQGFWMDIG QPKDFLTGMC LFLKSLRQKH 250 260 270 280 290 300 PEQLCSGPGI VGNVLVDPRA RIGENCSIGP NVSLGPGVVV EDGVCIRRCT VLRDAHIRSH 310 320 330 340 350 360 SWLESCIVGW RCRVGQWVRM ENVTVLGEDV IVNDELYLNG ASVLPHKSIG ESVPEPRIIM

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC110188 mRNA. Translation: AAI10189.1.
IPI	IPI00694699.
RefSeq	NP_001039633.1.
UniGene	Bt.74381
3D structure databases
HSSP	HSSP built from PDB template 1WVC based on UniProtKB P26396.
SMR	Q2YDJ9. Positions 1-329.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YDJ9.
Genome annotation databases
Ensembl	ENSBTAT00000015403; ENSBTAP00000015403; ENSBTAG00000032026; Bos taurus. [Genome view]
GeneID	514161.
KEGG	bta:514161.
Organism-specific databases
CTD	514161.
Phylogenomic databases
eggNOG	maNOG14488.
HOVERGEN	Q2YDJ9.
InParanoid	Q2YDJ9.
PhylomeDB	Q2YDJ9.
Enzyme and pathway databases
BRENDA	2.7.7.13. 251.
Family and domain databases
InterPro	IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPB_BOVIN

Accession

Primary (citable) accession number: Q2YDJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 20, 2005
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)