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Protein

Ferritin, mitochondrial

Gene

FTMT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Iron 1PROSITE-ProRule annotation1
Metal bindingi122Iron 1PROSITE-ProRule annotation1
Metal bindingi122Iron 2PROSITE-ProRule annotation1
Metal bindingi125Iron 1PROSITE-ProRule annotation1
Metal bindingi167Iron 2PROSITE-ProRule annotation1
Metal bindingi201Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, mitochondrial (EC:1.16.3.1)
Gene namesi
Name:FTMT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
ChainiPRO_000025236650 – 242Ferritin, mitochondrialAdd BLAST193

Proteomic databases

PaxDbiQ2YDI9.
PRIDEiQ2YDI9.

Interactioni

Subunit structurei

Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041498.

Structurei

3D structure databases

ProteinModelPortaliQ2YDI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 219Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ2YDI9.
KOiK18495.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YDI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPCSLFLPK HISTSLVFLR SARHGFALLP RWVPRLSSDY PPAAPIRLLA
60 70 80 90 100
AAASSRRPAD GAGAPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY
110 120 130 140 150
FSRDDVALHN FARYFLRLSR EEAEHAEKLM RLQNQRGGLI CLQDIKKPDQ
160 170 180 190 200
NDWKSGLNAM ECALLLEKNV NQSLLELHTL ASDKGDPHLC DFLETHYLNE
210 220 230 240
QVKSIKELGD HVNNLVKMGA PESGLAEYLF DKHTLGNENN HN
Length:242
Mass (Da):27,366
Last modified:December 20, 2005 - v1
Checksum:iB2B73D45C936A669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110199 mRNA. Translation: AAI10200.1.
RefSeqiNP_001069658.1. NM_001076190.1.
UniGeneiBt.56226.

Genome annotation databases

GeneIDi539838.
KEGGibta:539838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110199 mRNA. Translation: AAI10200.1.
RefSeqiNP_001069658.1. NM_001076190.1.
UniGeneiBt.56226.

3D structure databases

ProteinModelPortaliQ2YDI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041498.

Proteomic databases

PaxDbiQ2YDI9.
PRIDEiQ2YDI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi539838.
KEGGibta:539838.

Organism-specific databases

CTDi94033.

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ2YDI9.
KOiK18495.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTMT_BOVIN
AccessioniPrimary (citable) accession number: Q2YDI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.