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Q2YDI9

- FTMT_BOVIN

UniProt

Q2YDI9 - FTMT_BOVIN

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Protein
Ferritin, mitochondrial
Gene
FTMT
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron 1 By similarity
Metal bindingi122 – 1221Iron 1 By similarity
Metal bindingi122 – 1221Iron 2 By similarity
Metal bindingi125 – 1251Iron 1 By similarity
Metal bindingi167 – 1671Iron 2 By similarity
Metal bindingi201 – 2011Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, mitochondrial (EC:1.16.3.1)
Gene namesi
Name:FTMT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949Mitochondrion Reviewed prediction
Add
BLAST
Chaini50 – 242193Ferritin, mitochondrial
PRO_0000252366Add
BLAST

Proteomic databases

PRIDEiQ2YDI9.

Interactioni

Subunit structurei

Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041498.

Structurei

3D structure databases

ProteinModelPortaliQ2YDI9.
SMRiQ2YDI9. Positions 66-235.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 219150Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ2YDI9.
KOiK00522.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YDI9-1 [UniParc]FASTAAdd to Basket

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MLPCSLFLPK HISTSLVFLR SARHGFALLP RWVPRLSSDY PPAAPIRLLA    50
AAASSRRPAD GAGAPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY 100
FSRDDVALHN FARYFLRLSR EEAEHAEKLM RLQNQRGGLI CLQDIKKPDQ 150
NDWKSGLNAM ECALLLEKNV NQSLLELHTL ASDKGDPHLC DFLETHYLNE 200
QVKSIKELGD HVNNLVKMGA PESGLAEYLF DKHTLGNENN HN 242
Length:242
Mass (Da):27,366
Last modified:December 20, 2005 - v1
Checksum:iB2B73D45C936A669
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC110199 mRNA. Translation: AAI10200.1.
RefSeqiNP_001069658.1. NM_001076190.1.
UniGeneiBt.56226.

Genome annotation databases

GeneIDi539838.
KEGGibta:539838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC110199 mRNA. Translation: AAI10200.1 .
RefSeqi NP_001069658.1. NM_001076190.1.
UniGenei Bt.56226.

3D structure databases

ProteinModelPortali Q2YDI9.
SMRi Q2YDI9. Positions 66-235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000041498.

Proteomic databases

PRIDEi Q2YDI9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 539838.
KEGGi bta:539838.

Organism-specific databases

CTDi 94033.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223383.
HOVERGENi HBG000410.
InParanoidi Q2YDI9.
KOi K00522.

Miscellaneous databases

NextBioi 20878252.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiFTMT_BOVIN
AccessioniPrimary (citable) accession number: Q2YDI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 20, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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