Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2YDI9 (FTMT_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin, mitochondrial

EC=1.16.3.1
Gene names
Name:FTMT
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4949Mitochondrion Potential
Chain50 – 242193Ferritin, mitochondrial
PRO_0000252366

Regions

Domain70 – 219150Ferritin-like diiron

Sites

Metal binding871Iron 1 By similarity
Metal binding1221Iron 1 By similarity
Metal binding1221Iron 2 By similarity
Metal binding1251Iron 1 By similarity
Metal binding1671Iron 2 By similarity
Metal binding2011Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YDI9 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: B2B73D45C936A669

FASTA24227,366
        10         20         30         40         50         60 
MLPCSLFLPK HISTSLVFLR SARHGFALLP RWVPRLSSDY PPAAPIRLLA AAASSRRPAD 

        70         80         90        100        110        120 
GAGAPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY FSRDDVALHN FARYFLRLSR 

       130        140        150        160        170        180 
EEAEHAEKLM RLQNQRGGLI CLQDIKKPDQ NDWKSGLNAM ECALLLEKNV NQSLLELHTL 

       190        200        210        220        230        240 
ASDKGDPHLC DFLETHYLNE QVKSIKELGD HVNNLVKMGA PESGLAEYLF DKHTLGNENN 


HN 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC110199 mRNA. Translation: AAI10200.1.
RefSeqNP_001069658.1. NM_001076190.1.
UniGeneBt.56226.

3D structure databases

ProteinModelPortalQ2YDI9.
SMRQ2YDI9. Positions 66-235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000041498.

Proteomic databases

PRIDEQ2YDI9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID539838.
KEGGbta:539838.

Organism-specific databases

CTD94033.

Phylogenomic databases

eggNOGCOG1528.
HOGENOMHOG000223383.
HOVERGENHBG000410.
InParanoidQ2YDI9.
KOK00522.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20878252.

Entry information

Entry nameFTMT_BOVIN
AccessionPrimary (citable) accession number: Q2YDI9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 20, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families