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Q2YDI9

- FTMT_BOVIN

UniProt

Q2YDI9 - FTMT_BOVIN

Protein

Ferritin, mitochondrial

Gene

FTMT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Iron 1PROSITE-ProRule annotation
    Metal bindingi122 – 1221Iron 1PROSITE-ProRule annotation
    Metal bindingi122 – 1221Iron 2PROSITE-ProRule annotation
    Metal bindingi125 – 1251Iron 1PROSITE-ProRule annotation
    Metal bindingi167 – 1671Iron 2PROSITE-ProRule annotation
    Metal bindingi201 – 2011Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin, mitochondrial (EC:1.16.3.1)
    Gene namesi
    Name:FTMT
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4949MitochondrionSequence AnalysisAdd
    BLAST
    Chaini50 – 242193Ferritin, mitochondrialPRO_0000252366Add
    BLAST

    Proteomic databases

    PRIDEiQ2YDI9.

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000041498.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YDI9.
    SMRiQ2YDI9. Positions 66-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 219150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1528.
    HOGENOMiHOG000223383.
    HOVERGENiHBG000410.
    InParanoidiQ2YDI9.
    KOiK00522.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2YDI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPCSLFLPK HISTSLVFLR SARHGFALLP RWVPRLSSDY PPAAPIRLLA    50
    AAASSRRPAD GAGAPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY 100
    FSRDDVALHN FARYFLRLSR EEAEHAEKLM RLQNQRGGLI CLQDIKKPDQ 150
    NDWKSGLNAM ECALLLEKNV NQSLLELHTL ASDKGDPHLC DFLETHYLNE 200
    QVKSIKELGD HVNNLVKMGA PESGLAEYLF DKHTLGNENN HN 242
    Length:242
    Mass (Da):27,366
    Last modified:December 20, 2005 - v1
    Checksum:iB2B73D45C936A669
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC110199 mRNA. Translation: AAI10200.1.
    RefSeqiNP_001069658.1. NM_001076190.1.
    UniGeneiBt.56226.

    Genome annotation databases

    GeneIDi539838.
    KEGGibta:539838.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC110199 mRNA. Translation: AAI10200.1 .
    RefSeqi NP_001069658.1. NM_001076190.1.
    UniGenei Bt.56226.

    3D structure databases

    ProteinModelPortali Q2YDI9.
    SMRi Q2YDI9. Positions 66-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000041498.

    Proteomic databases

    PRIDEi Q2YDI9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 539838.
    KEGGi bta:539838.

    Organism-specific databases

    CTDi 94033.

    Phylogenomic databases

    eggNOGi COG1528.
    HOGENOMi HOG000223383.
    HOVERGENi HBG000410.
    InParanoidi Q2YDI9.
    KOi K00522.

    Miscellaneous databases

    NextBioi 20878252.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiFTMT_BOVIN
    AccessioniPrimary (citable) accession number: Q2YDI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3