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Protein

Origin recognition complex subunit 4

Gene

ORC4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 74ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-176187. Activation of ATR in response to replication stress.
R-BTA-68616. Assembly of the ORC complex at the origin of replication.
R-BTA-68689. CDC6 association with the ORC:origin complex.
R-BTA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-BTA-68867. Assembly of the pre-replicative complex.
R-BTA-68949. Orc1 removal from chromatin.
R-BTA-68962. Activation of the pre-replicative complex.
R-BTA-69298. Association of licensing factors with the pre-replicative complex.
R-BTA-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 4
Gene namesi
Name:ORC4
Synonyms:ORC4L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453491 – 436Origin recognition complex subunit 4Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N6-methyllysineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ2YDI2.
PRIDEiQ2YDI2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015291.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4 (By similarity). Interacts with POLQ (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020335.

Structurei

3D structure databases

ProteinModelPortaliQ2YDI2.
SMRiQ2YDI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC4 family.Curated

Phylogenomic databases

eggNOGiKOG2228. Eukaryota.
ENOG410XSK0. LUCA.
GeneTreeiENSGT00390000016542.
HOGENOMiHOG000007226.
HOVERGENiHBG000253.
InParanoidiQ2YDI2.
KOiK02606.
OMAiFQKFIQR.
OrthoDBiEOG091G0842.
TreeFamiTF101094.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR016527. ORC4.
IPR032705. ORC4_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12087:SF0. PTHR12087:SF0. 1 hit.
PfamiPF14629. ORC4_C. 1 hit.
[Graphical view]
PIRSFiPIRSF007858. ORC4. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YDI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRKSKSSN LIQADYISQV QRILRERFCH QSPHGNLFGV QVQYKHLIEL
60 70 80 90 100
LKRTAIHGES NSILIIGPRG SGKTMLINHA LKELMEIEGV SENILQVHLN
110 120 130 140 150
GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL EALKKGDRTS
160 170 180 190 200
SCPVIFILDE FDLFAHHKNQ TLLYNLLDIS QSAQTPVVII GLTCRLDILE
210 220 230 240 250
LLEKRVKSRF SHRQIHLMNS FSFPQYLKIF KEQLSLPSVF PEEIFAEKWN
260 270 280 290 300
ENVQSLSEDR SVKEVLQKHF NVSKNLRSLH MLLMLALNRV TPSHPFITAA
310 320 330 340 350
DLMEANQLCS MDSKGNIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY
360 370 380 390 400
NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ QLELIRPMER TSVNAQREYQ
410 420 430
LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL
Length:436
Mass (Da):50,327
Last modified:December 20, 2005 - v1
Checksum:i92C736F896FB3AE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110211 mRNA. Translation: AAI10212.1.
RefSeqiNP_001039766.1. NM_001046301.2.
XP_005202501.1. XM_005202444.3.
UniGeneiBt.13189.

Genome annotation databases

EnsembliENSBTAT00000020335; ENSBTAP00000020335; ENSBTAG00000015291.
GeneIDi529245.
KEGGibta:529245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110211 mRNA. Translation: AAI10212.1.
RefSeqiNP_001039766.1. NM_001046301.2.
XP_005202501.1. XM_005202444.3.
UniGeneiBt.13189.

3D structure databases

ProteinModelPortaliQ2YDI2.
SMRiQ2YDI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020335.

Proteomic databases

PaxDbiQ2YDI2.
PRIDEiQ2YDI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020335; ENSBTAP00000020335; ENSBTAG00000015291.
GeneIDi529245.
KEGGibta:529245.

Organism-specific databases

CTDi5000.

Phylogenomic databases

eggNOGiKOG2228. Eukaryota.
ENOG410XSK0. LUCA.
GeneTreeiENSGT00390000016542.
HOGENOMiHOG000007226.
HOVERGENiHBG000253.
InParanoidiQ2YDI2.
KOiK02606.
OMAiFQKFIQR.
OrthoDBiEOG091G0842.
TreeFamiTF101094.

Enzyme and pathway databases

ReactomeiR-BTA-176187. Activation of ATR in response to replication stress.
R-BTA-68616. Assembly of the ORC complex at the origin of replication.
R-BTA-68689. CDC6 association with the ORC:origin complex.
R-BTA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-BTA-68867. Assembly of the pre-replicative complex.
R-BTA-68949. Orc1 removal from chromatin.
R-BTA-68962. Activation of the pre-replicative complex.
R-BTA-69298. Association of licensing factors with the pre-replicative complex.
R-BTA-69300. Removal of licensing factors from origins.

Gene expression databases

BgeeiENSBTAG00000015291.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR016527. ORC4.
IPR032705. ORC4_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12087:SF0. PTHR12087:SF0. 1 hit.
PfamiPF14629. ORC4_C. 1 hit.
[Graphical view]
PIRSFiPIRSF007858. ORC4. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiORC4_BOVIN
AccessioniPrimary (citable) accession number: Q2YDI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.