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Protein

Anaphase-promoting complex subunit 10

Gene

ANAPC10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 10
Short name:
APC10
Alternative name(s):
Cyclosome subunit 10
Gene namesi
Name:ANAPC10
Synonyms:APC10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003459592 – 185Anaphase-promoting complex subunit 10Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei169N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2YDH1.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. The C-terminus of APC10 binds to CDC27/APC3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017721.

Structurei

3D structure databases

ProteinModelPortaliQ2YDH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 185DOCPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Belongs to the APC10 family.Curated
Contains 1 DOC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3437. Eukaryota.
COG5156. LUCA.
HOGENOMiHOG000241616.
HOVERGENiHBG050528.
InParanoidiQ2YDH1.
KOiK03357.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR016901. APC10.
IPR004939. APC_su10/DOC_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
[Graphical view]
PIRSFiPIRSF028841. APC10_sub. 1 hit.
SMARTiSM01337. APC10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YDH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL
60 70 80 90 100
ETYWQSDGSQ PHLVNLQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN
110 120 130 140 150
NFHNLQEIRQ LELVEPSGWI HVPLTDNHKK PTRTFMIQIA VLANHQNGRD
160 170 180
THMRQIKIYT PVEESSIGKF PRCTTIDFMM YRSIR
Length:185
Mass (Da):21,252
Last modified:December 20, 2005 - v1
Checksum:i0CA2F245B3831FF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110224 mRNA. Translation: AAI10225.1.
RefSeqiNP_001073826.1. NM_001080357.2.
UniGeneiBt.17077.

Genome annotation databases

GeneIDi783986.
KEGGibta:783986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110224 mRNA. Translation: AAI10225.1.
RefSeqiNP_001073826.1. NM_001080357.2.
UniGeneiBt.17077.

3D structure databases

ProteinModelPortaliQ2YDH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017721.

Proteomic databases

PaxDbiQ2YDH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi783986.
KEGGibta:783986.

Organism-specific databases

CTDi10393.

Phylogenomic databases

eggNOGiKOG3437. Eukaryota.
COG5156. LUCA.
HOGENOMiHOG000241616.
HOVERGENiHBG050528.
InParanoidiQ2YDH1.
KOiK03357.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR016901. APC10.
IPR004939. APC_su10/DOC_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
[Graphical view]
PIRSFiPIRSF028841. APC10_sub. 1 hit.
SMARTiSM01337. APC10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPC10_BOVIN
AccessioniPrimary (citable) accession number: Q2YDH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 20, 2005
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.