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Protein

Sperm acrosome membrane-associated protein 1

Gene

SPACA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome membrane-associated protein 1
Gene namesi
Name:SPACA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 221ExtracellularSequence analysisAdd BLAST192
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 279CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000024815130 – 279Sperm acrosome membrane-associated protein 1Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei262PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2YDG7
PRIDEiQ2YDG7

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025934

Structurei

3D structure databases

SMRiQ2YDG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFV6 Eukaryota
ENOG410YPX9 LUCA
HOGENOMiHOG000049221
HOVERGENiHBG080320
InParanoidiQ2YDG7

Family and domain databases

CDDicd13783 SPACA1, 1 hit
InterProiView protein in InterPro
IPR037878 SPACA1

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YDG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSRGAGCSA RLLLTVGWLL LAGLQSTCGI NVTAIQDPSL AREGEGEPEG
60 70 80 90 100
DEEPENDSET EKEPQAEAED DSEGIGIREV ILTSGCPGGE SKCIVRVEEC
110 120 130 140 150
RGPVDCGWGR PISESLEHVR LACVHTSPEN RFKYIWRLLR PDQQAIILAN
160 170 180 190 200
DSAILEVHRD THPKAFECET LDNNEIVASI RFTIYTTTEL QMKRASRPDT
210 220 230 240 250
DAVLVFVLTI GVIICIFVIF VLIFIIINWT AVKDFWAKAS TTEIQSELSS
260 270
MRYKDSTSLD QSPTDIPGHE DDALSEWNE
Length:279
Mass (Da):30,939
Last modified:December 20, 2005 - v1
Checksum:iF1ACB2C1882A012F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110228 mRNA Translation: AAI10229.1
RefSeqiNP_001040010.1, NM_001046545.1
UniGeneiBt.55305

Genome annotation databases

GeneIDi614884
KEGGibta:614884

Similar proteinsi

Entry informationi

Entry nameiSACA1_BOVIN
AccessioniPrimary (citable) accession number: Q2YDG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 20, 2005
Last modified: April 25, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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