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Protein

G-protein coupled receptor family C group 5 member C

Gene

GPRC5C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member C
Gene namesi
Name:GPRC5C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 50ExtracellularSequence analysisAdd BLAST27
Transmembranei51 – 71Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini72 – 85CytoplasmicSequence analysisAdd BLAST14
Transmembranei86 – 106Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini107 – 120ExtracellularSequence analysisAdd BLAST14
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 155CytoplasmicSequence analysisAdd BLAST14
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 209ExtracellularSequence analysisAdd BLAST33
Transmembranei210 – 230Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini231 – 242CytoplasmicSequence analysisAdd BLAST12
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 280ExtracellularSequence analysisAdd BLAST17
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 442CytoplasmicSequence analysisAdd BLAST141

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000025113524 – 442G-protein coupled receptor family C group 5 member CAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Modified residuei345PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei404PhosphoserineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei415PhosphotyrosineBy similarity1
Modified residuei424PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2YDG0.
PRIDEiQ2YDG0.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024834.

Structurei

3D structure databases

ProteinModelPortaliQ2YDG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ2YDG0.
KOiK04620.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2YDG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIHRTVLMC LGLPLFLLPG ARAQEQAPPG CSPDLNPLYY NLCDRSEAWG
60 70 80 90 100
IILEAVAGAG VVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL
110 120 130 140 150
FCLVFACVVK PSFSTCASRR FLFGVLFAIC FSCLVAHVLA LHFLVRKNHG
160 170 180 190 200
PRGWVIFLVA LLLSLVEVII NTEWLIITLV RGAGTEGDAL GNGSAGWVAV
210 220 230 240 250
SPCAIANADF VMALIYVMLL LLCAFSGAWS ALCGRFKRWR KHGVFILLTT
260 270 280 290 300
TASIAVWVVW IVMYTYGNRQ HNSPTWDDPT LAIALATNAW AFVLFYVIPE
310 320 330 340 350
VSQVTRSSPE QSYQGDLYPT RGVGYETILK EQKGQSMFVE NKAFSMDEPA
360 370 380 390 400
SAKRPVSPYS GYNGQLLTSM YQPTEMTLMH KAPSDGAYDV ILPRATANSQ
410 420 430 440
VTGSANSTLR AEDIYAAQGR QEATLPKEGK NSQVFRNPYV WD
Length:442
Mass (Da):48,459
Last modified:October 3, 2006 - v2
Checksum:iB2A5434AA562DF31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110241 mRNA. Translation: AAI10242.2.
RefSeqiNP_001258939.1. NM_001272010.1.
UniGeneiBt.111423.
Bt.56338.

Genome annotation databases

GeneIDi535664.
KEGGibta:535664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110241 mRNA. Translation: AAI10242.2.
RefSeqiNP_001258939.1. NM_001272010.1.
UniGeneiBt.111423.
Bt.56338.

3D structure databases

ProteinModelPortaliQ2YDG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024834.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ2YDG0.
PRIDEiQ2YDG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi535664.
KEGGibta:535664.

Organism-specific databases

CTDi55890.

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ2YDG0.
KOiK04620.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC5C_BOVIN
AccessioniPrimary (citable) accession number: Q2YDG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.