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Q2YDF1

- TRMB_BOVIN

UniProt

Q2YDF1 - TRMB_BOVIN

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

METTL1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei161 – 1611S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei164 – 1641UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB
  2. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA (guanine-N7)-methylation Source: GOC
  2. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 1UniRule annotation
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:METTL1UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleolus Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277tRNA (guanine-N(7)-)-methyltransferasePRO_0000284065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281Phosphoserine; by PKB and RPS6KA3UniRule annotation

Post-translational modificationi

Phosphorylation at Ser-28 inactivates its catalytic activity but does not affect the interaction with WDR4.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2YDF1.

Interactioni

Subunit structurei

Forms a complex with WDR4.UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022487.

Structurei

3D structure databases

ProteinModelPortaliQ2YDF1.
SMRiQ2YDF1. Positions 38-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni108 – 1092S-adenosyl-L-methionine bindingUniRule annotation
Regioni141 – 1422S-adenosyl-L-methionine bindingUniRule annotation
Regioni239 – 2413S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
GeneTreeiENSGT00390000017840.
HOGENOMiHOG000260965.
HOVERGENiHBG044569.
InParanoidiQ2YDF1.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG7PS1GC.
TreeFamiTF314083.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YDF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGTETGDAA GTEAPQPQKR YYRQRAHSNP MADHTLRYPV KPEDMDWSEL
60 70 80 90 100
YPEFFAPLPQ NQSHDDPKDK KEKRAQAQVE FADIGCGYGG LLVELSPLFP
110 120 130 140 150
DTLILGLEIR VKVSDYVQDR IRALRAAPGG GFQNIACLRS NAMKHLPNFF
160 170 180 190 200
HKGQLTKMFF LFPDPHFKRT KHKWRIISPT LLAEYAYVLR VGGLVYTITD
210 220 230 240 250
VLELHEWMCT HFEGHPLFER VPLEELSEDP IVGHLGTSTE EGKKVLRNGG
260 270
KNFPAIFRRI QDPALPAVTP TPTPPGH
Length:277
Mass (Da):31,323
Last modified:December 20, 2005 - v1
Checksum:i4860363A97727ADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT029912 mRNA. Translation: ABM06158.1.
BC110252 mRNA. Translation: AAI10253.1.
RefSeqiNP_001039542.1. NM_001046077.2.
UniGeneiBt.5722.

Genome annotation databases

EnsembliENSBTAT00000022487; ENSBTAP00000022487; ENSBTAG00000016908.
GeneIDi511197.
KEGGibta:511197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT029912 mRNA. Translation: ABM06158.1 .
BC110252 mRNA. Translation: AAI10253.1 .
RefSeqi NP_001039542.1. NM_001046077.2.
UniGenei Bt.5722.

3D structure databases

ProteinModelPortali Q2YDF1.
SMRi Q2YDF1. Positions 38-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000022487.

Proteomic databases

PRIDEi Q2YDF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000022487 ; ENSBTAP00000022487 ; ENSBTAG00000016908 .
GeneIDi 511197.
KEGGi bta:511197.

Organism-specific databases

CTDi 4234.

Phylogenomic databases

eggNOGi COG0220.
GeneTreei ENSGT00390000017840.
HOGENOMi HOG000260965.
HOVERGENi HBG044569.
InParanoidi Q2YDF1.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG7PS1GC.
TreeFami TF314083.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Miscellaneous databases

NextBioi 20869815.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiTRMB_BOVIN
AccessioniPrimary (citable) accession number: Q2YDF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3