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Q2YCH6

- GCH4_NITMU

UniProt

Q2YCH6 - GCH4_NITMU

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei149 – 1491May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciNMUL323848:GKEC-243-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Nmul_A0237
    OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
    Taxonomic identifieri323848 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
    ProteomesiUP000002718: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263GTP cyclohydrolase FolE2PRO_0000289502Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323848.Nmul_A0237.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YCH6.
    SMRiQ2YCH6. Positions 18-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YCH6-1 [UniParc]FASTAAdd to Basket

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    MNKMLIADVQ SVADTRRIAI DKAGIRAIRH PVRIMDKAGV QHTVAVFNMY    50
    VNLAHHLKGV HMSRFVEMLN EHDSVISVET FEKLLISMVK KLEAESGDIE 100
    MRFPYFIGKT APVSGIKSLM DYDVTFIGQT RNGESRFTLK VVVPVTSLCP 150
    CSKEVSDDGA HNQRSHISIS IRANHFVWIE DLIRIAEDQA SCELYGLLKR 200
    SDEKYVTEKA YGNPKFVEDA VRDIASVLDR DERIDAYTVE AENFESIHNH 250
    SAYALIECDK LKN 263
    Length:263
    Mass (Da):29,773
    Last modified:December 20, 2005 - v1
    Checksum:iD696D2689AEA7A8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000103 Genomic DNA. Translation: ABB73545.1.
    RefSeqiYP_410937.1. NC_007614.1.

    Genome annotation databases

    EnsemblBacteriaiABB73545; ABB73545; Nmul_A0237.
    GeneIDi3786319.
    KEGGinmu:Nmul_A0237.
    PATRICi22723372. VBINitMul110821_0272.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000103 Genomic DNA. Translation: ABB73545.1 .
    RefSeqi YP_410937.1. NC_007614.1.

    3D structure databases

    ProteinModelPortali Q2YCH6.
    SMRi Q2YCH6. Positions 18-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323848.Nmul_A0237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB73545 ; ABB73545 ; Nmul_A0237 .
    GeneIDi 3786319.
    KEGGi nmu:Nmul_A0237.
    PATRICi 22723372. VBINitMul110821_0272.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci NMUL323848:GKEC-243-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25196 / NCIMB 11849.

    Entry informationi

    Entry nameiGCH4_NITMU
    AccessioniPrimary (citable) accession number: Q2YCH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3