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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciNMUL323848:G1GTI-410-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Nmul_A0393
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201111 – 312Methionyl-tRNA formyltransferaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A0393

Structurei

3D structure databases

ProteinModelPortaliQ2YC20
SMRiQ2YC20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YC20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIIFAGTPP FAAAALEALA DAGHEIALVL TQPDRPAGRG MKNASSAVKL
60 70 80 90 100
LAQKRGFGLL QPPSLRQPEL HMQLEAVRAD IMVVAAYGLI LPFSVLNIPK
110 120 130 140 150
LGCVNIHASL LPRWRGAAPI ERAILAGDRE TGITIMQMDR GLDTGPILLV
160 170 180 190 200
RSITIAKDDT AGTLHEKLGQ LGAACIVEAL ALLQQGKIIA TPQNDLAATY
210 220 230 240 250
ASKLEKTEAE IDWRMDAENI DRAVRAFNPR PGMHSTVNGI SMKVWQTSVD
260 270 280 290 300
IAETDEKPGE IVAIRPDGIV VACGKHALIL KIVQKSGGKK LRSAEFLLGH
310
SLHPHDRFES GE
Length:312
Mass (Da):33,546
Last modified:December 20, 2005 - v1
Checksum:i0B4CD427EB2F1726
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB73701.1
RefSeqiWP_011379755.1, NZ_FNVK01000001.1

Genome annotation databases

EnsemblBacteriaiABB73701; ABB73701; Nmul_A0393
KEGGinmu:Nmul_A0393

Similar proteinsi

Entry informationi

Entry nameiFMT_NITMU
AccessioniPrimary (citable) accession number: Q2YC20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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