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Q2YBQ2

- SYL_NITMU

UniProt

Q2YBQ2 - SYL_NITMU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei627 – 6271ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNMUL323848:GKEC-527-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Nmul_A0511
    OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
    Taxonomic identifieri323848 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
    ProteomesiUP000002718: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 866866Leucine--tRNA ligasePRO_1000009380Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323848.Nmul_A0511.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YBQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi624 – 6285"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YBQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEKYHPQEI ESEAQQYWQQ TAAFKAVEAP EKRKYYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VLSRYHRMQG YNVLQPMGWD AFGLPAENAA MQNNVPPAKW 100
    TYDNIAYMRK QLQSLGLAMD WDRELATCQP DYYRWNQWLF LRMLEKGLAY 150
    RTTGIVNWDP VDQTVLANEQ VIDGRGWRTG ALVEKHEIPM YYMKITAYAD 200
    ELLEALNALP GWPERVRTMQ ANWIGKSFGV EVRFPADAES GMPQDLKVFT 250
    TRADTLFGVT YVAVAAEHPV AQHAAKSNPA LAAFIEECRQ GAMMEAELAT 300
    QEKKGRDTGL YVIHPLTGAR LPVWIANYVL MGYGEGAVMA VPAHDERDFE 350
    FATQYSLPIR AVIKPVDSGL TVPLAQAYVE HGITFDSGEF SGLAFQPAVD 400
    AIAVALQQKG LGEKRVHYRL RDWGISRQRY WGCPIPLIYC DACGVVPVPD 450
    EQLPVVLPED LVPDGSGNPL AKTPSFYECS CPRCGQSARR ETDTMDTFVD 500
    SSWYYIRYAC TDQHRAMVDA RVDYWLPVDQ YIGGIEHAIL HLLYSRFWSK 550
    VMRDLGLVLF DEPFANLLTQ GMVLNEIMFR KTGSGRIVYF NPADVDIQTD 600
    EQGRRIGAVL RADGQPVEAG GIGTMSKSRN NGVDPQKLVE QYGADTARLF 650
    MMFASPPEQT LEWADAGVEG AFRFLKRLWK QVYDHLQQSG VANGPIPVAG 700
    LGPELKALRF QLHQTIAKVG DDLGRRHTFN TAIAAVMELM NALGKLQDSS 750
    PSARGLMQEA LENIVLLLSP IVPHICHVLW RELRPGTELL DQPWPQADVA 800
    ALVQDEIELI VQVNGKLRGK IRVAADTKPV IVEQLALENE QVRRFIDGKA 850
    VKKVVMVPGK LVNIVI 866
    Length:866
    Mass (Da):97,239
    Last modified:December 20, 2005 - v1
    Checksum:i9D6E9F9C850663CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000103 Genomic DNA. Translation: ABB73819.1.
    RefSeqiWP_011379873.1. NC_007614.1.
    YP_411211.1. NC_007614.1.

    Genome annotation databases

    EnsemblBacteriaiABB73819; ABB73819; Nmul_A0511.
    GeneIDi3785640.
    KEGGinmu:Nmul_A0511.
    PATRICi22724022. VBINitMul110821_0587.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000103 Genomic DNA. Translation: ABB73819.1 .
    RefSeqi WP_011379873.1. NC_007614.1.
    YP_411211.1. NC_007614.1.

    3D structure databases

    ProteinModelPortali Q2YBQ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323848.Nmul_A0511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB73819 ; ABB73819 ; Nmul_A0511 .
    GeneIDi 3785640.
    KEGGi nmu:Nmul_A0511.
    PATRICi 22724022. VBINitMul110821_0587.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci NMUL323848:GKEC-527-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25196 / NCIMB 11849.

    Entry informationi

    Entry nameiSYL_NITMU
    AccessioniPrimary (citable) accession number: Q2YBQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3