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Q2YBQ2

- SYL_NITMU

UniProt

Q2YBQ2 - SYL_NITMU

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMUL323848:GKEC-527-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Nmul_A0511
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
ProteomesiUP000002718: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 866866Leucine--tRNA ligasePRO_1000009380Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A0511.

Structurei

3D structure databases

ProteinModelPortaliQ2YBQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi624 – 6285"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YBQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEKYHPQEI ESEAQQYWQQ TAAFKAVEAP EKRKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRYHRMQG YNVLQPMGWD AFGLPAENAA MQNNVPPAKW
110 120 130 140 150
TYDNIAYMRK QLQSLGLAMD WDRELATCQP DYYRWNQWLF LRMLEKGLAY
160 170 180 190 200
RTTGIVNWDP VDQTVLANEQ VIDGRGWRTG ALVEKHEIPM YYMKITAYAD
210 220 230 240 250
ELLEALNALP GWPERVRTMQ ANWIGKSFGV EVRFPADAES GMPQDLKVFT
260 270 280 290 300
TRADTLFGVT YVAVAAEHPV AQHAAKSNPA LAAFIEECRQ GAMMEAELAT
310 320 330 340 350
QEKKGRDTGL YVIHPLTGAR LPVWIANYVL MGYGEGAVMA VPAHDERDFE
360 370 380 390 400
FATQYSLPIR AVIKPVDSGL TVPLAQAYVE HGITFDSGEF SGLAFQPAVD
410 420 430 440 450
AIAVALQQKG LGEKRVHYRL RDWGISRQRY WGCPIPLIYC DACGVVPVPD
460 470 480 490 500
EQLPVVLPED LVPDGSGNPL AKTPSFYECS CPRCGQSARR ETDTMDTFVD
510 520 530 540 550
SSWYYIRYAC TDQHRAMVDA RVDYWLPVDQ YIGGIEHAIL HLLYSRFWSK
560 570 580 590 600
VMRDLGLVLF DEPFANLLTQ GMVLNEIMFR KTGSGRIVYF NPADVDIQTD
610 620 630 640 650
EQGRRIGAVL RADGQPVEAG GIGTMSKSRN NGVDPQKLVE QYGADTARLF
660 670 680 690 700
MMFASPPEQT LEWADAGVEG AFRFLKRLWK QVYDHLQQSG VANGPIPVAG
710 720 730 740 750
LGPELKALRF QLHQTIAKVG DDLGRRHTFN TAIAAVMELM NALGKLQDSS
760 770 780 790 800
PSARGLMQEA LENIVLLLSP IVPHICHVLW RELRPGTELL DQPWPQADVA
810 820 830 840 850
ALVQDEIELI VQVNGKLRGK IRVAADTKPV IVEQLALENE QVRRFIDGKA
860
VKKVVMVPGK LVNIVI
Length:866
Mass (Da):97,239
Last modified:December 20, 2005 - v1
Checksum:i9D6E9F9C850663CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA. Translation: ABB73819.1.
RefSeqiYP_411211.1. NC_007614.1.

Genome annotation databases

EnsemblBacteriaiABB73819; ABB73819; Nmul_A0511.
GeneIDi3785640.
KEGGinmu:Nmul_A0511.
PATRICi22724022. VBINitMul110821_0587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA. Translation: ABB73819.1 .
RefSeqi YP_411211.1. NC_007614.1.

3D structure databases

ProteinModelPortali Q2YBQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323848.Nmul_A0511.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB73819 ; ABB73819 ; Nmul_A0511 .
GeneIDi 3785640.
KEGGi nmu:Nmul_A0511.
PATRICi 22724022. VBINitMul110821_0587.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NMUL323848:GKEC-527-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25196 / NCIMB 11849.

Entry informationi

Entry nameiSYL_NITMU
AccessioniPrimary (citable) accession number: Q2YBQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3