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Q2YB78

- RBL_NITMU

UniProt

Q2YB78 - RBL_NITMU

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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281Substrate; in homodimeric partnerUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Active sitei180 – 1801Proton acceptorUniRule annotation
Binding sitei182 – 1821SubstrateUniRule annotation
Metal bindingi206 – 2061Magnesium; via carbamate groupUniRule annotation
Metal bindingi208 – 2081MagnesiumUniRule annotation
Metal bindingi209 – 2091MagnesiumUniRule annotation
Active sitei298 – 2981Proton acceptorUniRule annotation
Binding sitei299 – 2991SubstrateUniRule annotation
Binding sitei331 – 3311SubstrateUniRule annotation
Sitei338 – 3381Transition state stabilizerUniRule annotation
Binding sitei383 – 3831SubstrateUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. monooxygenase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. reductive pentose-phosphate cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Calvin cycle, Carbon dioxide fixation

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciNMUL323848:GKEC-703-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Ordered Locus Names:Nmul_A0686
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
ProteomesiUP000002718: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Ribulose bisphosphate carboxylase large chainPRO_0000251449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061N6-carboxylysineUniRule annotation

Proteomic databases

PRIDEiQ2YB78.

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Protein-protein interaction databases

STRINGi323848.Nmul_A0686.

Structurei

3D structure databases

ProteinModelPortaliQ2YB78.
SMRiQ2YB78. Positions 10-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.
OrthoDBiEOG6ZKXMS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1.
InterProiIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YB78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEAITGAER YKSGVIPYKK MGYWEPDYVP KDTDIIAMFR ITPQAGVEPE
60 70 80 90 100
EAAAAVAGES STATWTVVWT DRLTACELYR AKAFRTDPVP NTGEGTKTEQ
110 120 130 140 150
QYFAYIAYDL DLFEPGSIAN LTASIIGNVF GFKAVKALRL EDMRIPVAYL
160 170 180 190 200
KTFQGPATGI IVERERLDKF GRPLLGATTK PKLGLSGRNY GRVVYEGLKG
210 220 230 240 250
GLDFMKDDEN INSQPFMHWR DRFLYCMEAV NKASAATGEV KGHYLNVTAG
260 270 280 290 300
TMEEMYERAE FAKSLGSVII MIDLVIGYTA IQSMAKWARK NDMILHLHRA
310 320 330 340 350
GNSTYSRQKN HGMNFRVICK WMRMAGVDHI HAGTVVGKLE GDPLMIKGFY
360 370 380 390 400
DTLRDRHTPV SLEHGLFFEQ DWASLNKVMP VASGGIHAGQ MHQLLDYLGE
410 420 430 440 450
DVILQFGGGT IGHPQGIQAG AVANRVALEA MIMARNEGRD YVKEGPQILE
460 470 480
EAAKWCTPLK LALDTWKDIT FNYESTDTAD FVPSETASV
Length:489
Mass (Da):54,315
Last modified:December 20, 2005 - v1
Checksum:i02CFEB7C9D0C2523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA. Translation: ABB73993.1.
RefSeqiYP_411385.1. NC_007614.1.

Genome annotation databases

EnsemblBacteriaiABB73993; ABB73993; Nmul_A0686.
GeneIDi3784063.
KEGGinmu:Nmul_A0686.
PATRICi22724432. VBINitMul110821_0791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA. Translation: ABB73993.1 .
RefSeqi YP_411385.1. NC_007614.1.

3D structure databases

ProteinModelPortali Q2YB78.
SMRi Q2YB78. Positions 10-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323848.Nmul_A0686.

Proteomic databases

PRIDEi Q2YB78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB73993 ; ABB73993 ; Nmul_A0686 .
GeneIDi 3784063.
KEGGi nmu:Nmul_A0686.
PATRICi 22724432. VBINitMul110821_0791.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.
OrthoDBi EOG6ZKXMS.

Enzyme and pathway databases

BioCyci NMUL323848:GKEC-703-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01338. RuBisCO_L_type1.
InterProi IPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25196 / NCIMB 11849.

Entry informationi

Entry nameiRBL_NITMU
AccessioniPrimary (citable) accession number: Q2YB78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 20, 2005
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3