Reviewed, UniProtKB/Swiss-Prot Q2YAU6 (HIS81_NITMU)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	Nmul_A0818

Organism

Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) [Complete proteome] [HAMAP]

Taxonomic identifier

323848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosospira

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000230217
Amino acid modifications
	Modified residue	220	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YAU6-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 75B602836D70F64D	FASTA	368	40,455
	10 20 30 40 50 60 MAVMPFSPDQ IIRPEILALS AYHVPPACGM IKLDAMENPY PLPPELRDEI AKLAGETPVN 70 80 90 100 110 120 RYPDPDAAAL KAALREALSI PDGMDIMLGN GSDEIIQIIA LACGKPGAVL MSVEPAFVMF 130 140 150 160 170 180 RMIATFASMN YVGVPLHPDF SLDAEAMLAA IARYQPAVIF IAYPNNPTGN LFDAVEISRI 190 200 210 220 230 240 IDAAPGVVVV DEAYHAFADA SFMDKLAHHP NLLLMRTLSK LGMAGLRLGL LAGKPEWLRQ 250 260 270 280 290 300 LEKLRLPYNV GIVTQRIAEK LLQHRDVLLQ QAAAIKLERS SMSRRLAELE GIEVFPTDAN 310 320 330 340 350 360 FILFRLNQDH KATQVFQELK QRGILVKNLD GAHPLLKNCL RVTVGMPDEN AQFLEVLQTL LVKVEAKA

References

[1]

"Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000103 Genomic DNA. Translation: ABB74125.1.
RefSeq	YP_411517.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YAU6.
Genome annotation databases
GeneID	3785862.
GenomeReviews	Gene locus Nmul_A0818 in contig CP000103_GR.
KEGG	nmu:Nmul_A0818.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2YAU6.
OMA	RIQTIEH.
Enzyme and pathway databases
BioCyc	NMUL323848:NMUL_A0818-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_NITMU

Accession

Primary (citable) accession number: Q2YAU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	December 20, 2005
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)