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Q2YAU5 (HISX_NITMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:Nmul_A0819
OrganismNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) [Complete proteome] [HAMAP]
Taxonomic identifier323848 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000229859

Sites

Active site3301Proton acceptor By similarity
Active site3311Proton acceptor By similarity
Metal binding2621Zinc By similarity
Metal binding2651Zinc By similarity
Metal binding3641Zinc By similarity
Metal binding4231Zinc By similarity
Binding site1331NAD By similarity
Binding site1941NAD By similarity
Binding site2171NAD By similarity
Binding site2401Substrate By similarity
Binding site2621Substrate By similarity
Binding site2651Substrate By similarity
Binding site3311Substrate By similarity
Binding site3641Substrate By similarity
Binding site4181Substrate By similarity
Binding site4231Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YAU5 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: B622959C7F8B3A80

FASTA44047,627
        10         20         30         40         50         60 
MISIKRLSSA DTEFDKALSE LLAFENTQDA KLEAAVADIL AKIRTEGDKA LLEYTLRFDR 

        70         80         90        100        110        120 
VDAKSAADLE LPRNRLQQAL HNLPGEQRNA LEQAAERVRV YHEKQLTQSW SYVEPDGTHL 

       130        140        150        160        170        180 
GQKITPLDRA GLYVPGGKAA YPSSVLMNAI PAKVAGVGEL VMVTPTPQGE VNDLVLAAAA 

       190        200        210        220        230        240 
ICEVDRVFTI GGAQAVGALA YGTPTVPRVD KIVGPGNAYV ATAKRHVFGV VGIDMLAGPS 

       250        260        270        280        290        300 
EILIICDGKT NPDWIAMDMF SQAEHDELAQ AILLSPDLHF IETVAASIVR QLETMPRKEI 

       310        320        330        340        350        360 
IRTSLENRSA LIQVHDLEEA CEIANSIAPE HLELSVEQPE KWVEKIRHAG AIFLGRHTSE 

       370        380        390        400        410        420 
ALGDYCAGPN HVLPTSRTAR FSSPLGVYDF QKRSSIIQVS GQGSAKLGAI ASILAQGEGL 

       430        440 
QAHAMSAEYR YTKKIALGKN 

« Hide

References

[1]"Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25196 / NCIMB 11849.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000103 Genomic DNA. Translation: ABB74126.1.
RefSeqYP_411518.1. NC_007614.1.

3D structure databases

ProteinModelPortalQ2YAU5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING323848.Nmul_A0819.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB74126; ABB74126; Nmul_A0819.
GeneID3786688.
KEGGnmu:Nmul_A0819.
PATRIC22724750. VBINitMul110821_0946.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAYAAKLCG.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

BioCycNMUL323848:GKEC-840-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_NITMU
AccessionPrimary (citable) accession number: Q2YAU5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways