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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE), Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI), Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB), Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD), Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133NADUniRule annotation1
Binding sitei194NADUniRule annotation1
Binding sitei217NADUniRule annotation1
Binding sitei240SubstrateUniRule annotation1
Metal bindingi262ZincUniRule annotation1
Binding sitei262SubstrateUniRule annotation1
Metal bindingi265ZincUniRule annotation1
Binding sitei265SubstrateUniRule annotation1
Active sitei330Proton acceptorUniRule annotation1
Active sitei331Proton acceptorUniRule annotation1
Binding sitei331SubstrateUniRule annotation1
Metal bindingi364ZincUniRule annotation1
Binding sitei364SubstrateUniRule annotation1
Binding sitei418SubstrateUniRule annotation1
Metal bindingi423ZincUniRule annotation1
Binding sitei423SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciNMUL323848:G1GTI-865-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Nmul_A0819
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002298591 – 440Histidinol dehydrogenaseAdd BLAST440

Proteomic databases

PRIDEiQ2YAU5

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A0819

Structurei

3D structure databases

ProteinModelPortaliQ2YAU5
SMRiQ2YAU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YAU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISIKRLSSA DTEFDKALSE LLAFENTQDA KLEAAVADIL AKIRTEGDKA
60 70 80 90 100
LLEYTLRFDR VDAKSAADLE LPRNRLQQAL HNLPGEQRNA LEQAAERVRV
110 120 130 140 150
YHEKQLTQSW SYVEPDGTHL GQKITPLDRA GLYVPGGKAA YPSSVLMNAI
160 170 180 190 200
PAKVAGVGEL VMVTPTPQGE VNDLVLAAAA ICEVDRVFTI GGAQAVGALA
210 220 230 240 250
YGTPTVPRVD KIVGPGNAYV ATAKRHVFGV VGIDMLAGPS EILIICDGKT
260 270 280 290 300
NPDWIAMDMF SQAEHDELAQ AILLSPDLHF IETVAASIVR QLETMPRKEI
310 320 330 340 350
IRTSLENRSA LIQVHDLEEA CEIANSIAPE HLELSVEQPE KWVEKIRHAG
360 370 380 390 400
AIFLGRHTSE ALGDYCAGPN HVLPTSRTAR FSSPLGVYDF QKRSSIIQVS
410 420 430 440
GQGSAKLGAI ASILAQGEGL QAHAMSAEYR YTKKIALGKN
Length:440
Mass (Da):47,627
Last modified:December 20, 2005 - v1
Checksum:iB622959C7F8B3A80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB74126.1
RefSeqiWP_011380174.1, NZ_FNVK01000036.1

Genome annotation databases

EnsemblBacteriaiABB74126; ABB74126; Nmul_A0819
KEGGinmu:Nmul_A0819

Similar proteinsi

Entry informationi

Entry nameiHISX_NITMU
AccessioniPrimary (citable) accession number: Q2YAU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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