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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2

Gene

gpmA2

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 (gpmA1), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 (gpmA2)
  4. Enolase (eno), Enolase (eno)
  5. Pyruvate kinase (Nmul_A0385), Pyruvate kinase (Nmul_A1507)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Active sitei87Proton donor/acceptorUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNMUL323848:G1GTI-1177-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2UniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAM 2UniRule annotation
Short name:
PGAM 2UniRule annotation
Short name:
Phosphoglyceromutase 2UniRule annotation
Short name:
dPGM 2UniRule annotation
Gene namesi
Name:gpmA2UniRule annotation
Ordered Locus Names:Nmul_A1121
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002291321 – 2512,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2Add BLAST251

Proteomic databases

PRIDEiQ2Y9Z7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi323848.Nmul_A1121

Structurei

3D structure databases

ProteinModelPortaliQ2Y9Z7
SMRiQ2Y9Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Substrate bindingUniRule annotation8
Regioni21 – 22Substrate bindingUniRule annotation2
Regioni87 – 90Substrate bindingUniRule annotation4
Regioni114 – 115Substrate bindingUniRule annotation2
Regioni183 – 184Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DKJ Bacteria
COG0588 LUCA
HOGENOMiHOG000221682
KOiK01834
OMAiRMLPYWY
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2Y9Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLVLLRHG ESTWNKENRF TGWTDVDLTP KGAEEAHNSG RLLREAGFTF
60 70 80 90 100
DIAYTSVLKR AIRTLWIVLD EMDQMWIPVE SSWRLNERHY GALQGLNKLE
110 120 130 140 150
TAVAYGEEQV LIWRRSYDIR PPALTPDDPR YPGCDPRYRN LPKQDIPLTE
160 170 180 190 200
CLQDTVSRFL PYWRESIAPQ VKSDKSVLIT AHGNSLRALV MYLDNLSEGE
210 220 230 240 250
IMELNIPTGI PLVYELDDGL KPIRSYYLGD QAKIEQAMQV VANQGKILPN

L
Length:251
Mass (Da):28,814
Last modified:December 20, 2005 - v1
Checksum:iF50D2CD7F99244BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB74424.1
RefSeqiWP_011380465.1, NZ_FNVK01000008.1

Genome annotation databases

EnsemblBacteriaiABB74424; ABB74424; Nmul_A1121
KEGGinmu:Nmul_A1121

Similar proteinsi

Entry informationi

Entry nameiGPMA2_NITMU
AccessioniPrimary (citable) accession number: Q2Y9Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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