Reviewed, UniProtKB/Swiss-Prot Q2Y9Z7 (GPMA2_NITMU)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2
      Short name=Phosphoglyceromutase 2
      Short name=PGAM 2
      Short name=BPG-dependent PGAM 2
      Short name=dPGM 2
    EC=5.4.2.1

Gene names

Name:	gpmA2
Ordered Locus Names:	Nmul_A1121

Organism

Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) [Complete proteome] [HAMAP]

Taxonomic identifier

323848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosospira

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 HAMAP MF_01039		PRO_0000229132
Sites
	Active site	9	1	Tele-phosphohistidine intermediate By similarity
	Active site	182	1	By similarity
	Site	60	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2Y9Z7-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: F50D2CD7F99244BB	FASTA	251	28,814
	10 20 30 40 50 60 MKKLVLLRHG ESTWNKENRF TGWTDVDLTP KGAEEAHNSG RLLREAGFTF DIAYTSVLKR 70 80 90 100 110 120 AIRTLWIVLD EMDQMWIPVE SSWRLNERHY GALQGLNKLE TAVAYGEEQV LIWRRSYDIR 130 140 150 160 170 180 PPALTPDDPR YPGCDPRYRN LPKQDIPLTE CLQDTVSRFL PYWRESIAPQ VKSDKSVLIT 190 200 210 220 230 240 AHGNSLRALV MYLDNLSEGE IMELNIPTGI PLVYELDDGL KPIRSYYLGD QAKIEQAMQV 250 VANQGKILPN L

References

[1]

"Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC 25196." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000103 Genomic DNA. Translation: ABB74424.1.
RefSeq	YP_411816.1.
3D structure databases
SMR	Q2Y9Z7. Positions 3-234.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2Y9Z7.
Genome annotation databases
GeneID	3785701.
GenomeReviews	Gene locus Nmul_A1121 in contig CP000103_GR.
KEGG	nmu:Nmul_A1121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0588.
HOGENOM	HBG658938.
OMA	VPLTECL.
PhylomeDB	Q2Y9Z7.
Enzyme and pathway databases
BioCyc	NMUL323848:NMUL_A1121-MONOMER.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA. [Tree]
InterPro	IPR001345. PG/BPGM_mutase_AS. IPR013078. PG_mutase. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA2_NITMU

Accession

Primary (citable) accession number: Q2Y9Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	December 20, 2005
Last modified:	February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)