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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processBiotin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciNMUL323848:G1GTI-1188-MONOMER
UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:Nmul_A1132
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004125141 – 307Malonyl-[acyl-carrier protein] O-methyltransferaseAdd BLAST307

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A1132

Structurei

3D structure databases

ProteinModelPortaliQ2Y9Y6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106T9E Bacteria
COG0500 LUCA
HOGENOMiHOG000265010
KOiK02169
OMAiATYQVVY
OrthoDBiPOG091H05JY

Family and domain databases

HAMAPiMF_00835 BioC, 1 hit
InterProiView protein in InterPro
IPR011814 BioC
IPR013216 Methyltransf_11
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02072 BioC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2Y9Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNESVVNY DHFIDKRRVR KAFERAAPLY DQAAVLQREV CDRMLSRLEY
60 70 80 90 100
IKYMPDVVLD AGSGTGYGTC KLLERYPDAS MLAIDIATGM HHQARQRMNS
110 120 130 140 150
MIPRWRQLFG VGRNQRTSRV RYVAGDIEQL PLEDSCAGLV WSNLALQWCN
160 170 180 190 200
DLKKTFDEMR RILKNGGLFM FSTFGPDTLK ELRQAFRHAD DYSHVNRFAD
210 220 230 240 250
MHDIGDMLVH SGFATPVMDM EYITLTYDEV ISVMRDLKAI GAHNATGARH
260 270 280 290 300
RGLTGKNAWQ KAIGHYETLR TGGKLPATFE VVYGHAWKPA PRTSILTPET

RRHIGLE
Length:307
Mass (Da):34,985
Last modified:December 20, 2005 - v1
Checksum:i05771169069D5213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB74435.1
RefSeqiWP_011380476.1, NC_007614.1

Genome annotation databases

EnsemblBacteriaiABB74435; ABB74435; Nmul_A1132
KEGGinmu:Nmul_A1132

Similar proteinsi

Entry informationi

Entry nameiBIOC_NITMU
AccessioniPrimary (citable) accession number: Q2Y9Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: December 20, 2005
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health